Claudio Sette Department of Biomedicine and Prevention, University of Rome Tor Vergata, Italy
1 protocol

Pamela Bielli
  • University of Rome Tor Vergata
Research focus
  • Molecular biology
  • 1 Author merit


Ph.D in Biology, University of Rome “Roma TRE” , Italy, 2002

Current position

Researcher, Department of Biomedicine and Prevention, University of Rome “Tor Vergata", Italy


  1. Naro, C., Jolly, A., Di Persio, S., Bielli, P., Setterblad, N., Alberdi, A. J., Vicini, E., Geremia, R., De la Grange, P. and Sette, C. (2017). An Orchestrated Intron Retention Program in Meiosis Controls Timely Usage of Transcripts during Germ Cell Differentiation. Dev Cell 41(1): 82-93 e84.
  2. Nazio, F., Carinci, M., Valacca, C., Bielli, P., Strappazzon, F., Antonioli, M., Ciccosanti, F., Rodolfo, C., Campello, S., Fimia, G. M., Sette, C., Bonaldo, P. and Cecconi, F. (2016). Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation. J Cell Biol 215(6): 841-856.
  3. La Rosa, P., Bielli, P., Compagnucci, C., Cesari, E., Volpe, E., Farioli Vecchioli, S. and Sette, C. (2016). Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing. Elife 5.
  4. Annibalini, G., Bielli, P., De Santi, M., Agostini, D., Guescini, M., Sisti, D., Contarelli, S., Brandi, G., Villarini, A., Stocchi, V., Sette, C. and Barbieri, E. (2016). MIR retroposon exonization promotes evolutionary variability and generates species-specific expression of IGF-1 splice variants. Biochim Biophys Acta 1859(5): 757-768.
  5. Calabretta, S., Bielli, P., Passacantilli, I., Pilozzi, E., Fendrich, V., Capurso, G., Fave, G. D. and Sette, C. (2016). Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells. Oncogene 35(16): 2031-2039.
  6. Naro, C., Bielli, P., Pagliarini, V. and Sette, C. (2015). The interplay between DNA damage response and RNA processing: the unexpected role of splicing factors as gatekeepers of genome stability. Front Genet 6: 142.
  7. Bielli, P., Bordi, M., Di Biasio, V. and Sette, C. (2014). Regulation of BCL-X splicing reveals a role for the polypyrimidine tract binding protein (PTBP1/hnRNP I) in alternative 5' splice site selection. Nucleic Acids Res 42(19): 12070-12081.
  8. Bielli, P., Busa, R., Di Stasi, S. M., Munoz, M. J., Botti, F., Kornblihtt, A. R. and Sette, C. (2014). The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis. EMBO Rep 15(4): 419-427.
  9. Cappellari, M., Bielli, P., Paronetto, M. P., Ciccosanti, F., Fimia, G. M., Saarikettu, J., Silvennoinen, O. and Sette, C. (2014). The transcriptional co-activator SND1 is a novel regulator of alternative splicing in prostate cancer cells. Oncogene 33(29): 3794-3802.
  10. Nazio, F., Strappazzon, F., Antonioli, M., Bielli, P., Cianfanelli, V., Bordi, M., Gretzmeier, C., Dengjel, J., Piacentini, M., Fimia, G. M. and Cecconi, F. (2013). mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6. Nat Cell Biol 15(4): 406-416.
  11. Fausti, F., Di Agostino, S., Cioce, M., Bielli, P., Sette, C., Pandolfi, P. P., Oren, M., Sudol, M., Strano, S. and Blandino, G. (2013). ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence. Cell Death Differ 20(11): 1498-1509.
  12. Bielli, P., Busa, R., Paronetto, M. P. and Sette, C. (2011). The RNA-binding protein Sam68 is a multifunctional player in human cancer. Endocr Relat Cancer 18(4): R91-R102.
  13. Pedrotti, S., Bielli, P., Paronetto, M. P., Ciccosanti, F., Fimia, G. M., Stamm, S., Manley, J. L. and Sette, C. (2010). The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy. EMBO J 29(7): 1235-1247.
  14. Bianchini, A., Loiarro, M., Bielli, P., Busa, R., Paronetto, M. P., Loreni, F., Geremia, R. and Sette, C. (2008). Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells. Carcinogenesis 29(12): 2279-2288.
  15. Casavola, E. C., Catucci, A., Bielli, P., Di Pentima, A., Porcu, G., Pennestri, M., Cicero, D. O. and Ragnini-Wilson, A. (2008). Ypt32p and Mlc1p bind within the vesicle binding region of the class V myosin Myo2p globular tail domain. Mol Microbiol 67(5): 1051-1066.
  16. Bielli, P., Casavola, E. C., Biroccio, A., Urbani, A. and Ragnini-Wilson, A. (2006). GTP drives myosin light chain 1 interaction with the class V myosin Myo2 IQ motifs via a Sec2 RabGEF-mediated pathway. Mol Microbiol 59(5): 1576-1590.
  17. Melino, S., Pennestri, M., Santoprete, A., Bielli, P., Paci, M., Ragnini-Wilson, A. and Cicero, D. O. (2005). Letter to the Editor: Assignment of the 1H, 13C and 15N resonances of Mlc1p from Saccharomyces cerevisiae. J Biomol NMR 31(4): 367-368.
  18. Wagner, W., Bielli, P., Wacha, S. and Ragnini-Wilson, A. (2002). Mlc1p promotes septum closure during cytokinesis via the IQ motifs of the vesicle motor Myo2p. EMBO J 21(23): 6397-6408.
  19. Bielli, P. and Calabrese, L. (2002). Structure to function relationships in ceruloplasmin: a 'moonlighting' protein. Cell Mol Life Sci 59(9): 1413-1427.
  20. Bielli, P., Bellenchi, G. C. and Calabrese, L. (2001). Site-directed mutagenesis of human ceruloplasmin:. production of a proteolytically stable protein and structure-activity relationships of type 1 sites. J Biol Chem 276(4): 2678-2685.
  21. Bonaccorsi di Patti, M. C., Bellenchi, G. C., Bielli, P. and Calabrese, L. (1999). Release of highly active Fet3 from membranes of the yeast Pichia pastoris by limited proteolysis. Arch Biochem Biophys 372(2): 295-299.
1 Protocol published
Authors:  Pamela Bielli and Claudio Sette, date: 05/20/2017, view: 8191, Q&A: 0
RNA metabolism is tightly controlled across different tissues and developmental stages, and its dysregulation is one of the molecular hallmarks of cancer. Through direct binding to specific sequence element(s), RNA binding proteins (RBPs) play a ...
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