Antonio Giordano 1 protocol

Alfano Luigi National Cancer Institute Pascale Foundation
1 protocol

Francesca Pentimalli
Research focus
  • Cancer biology
  • 1 Author merit


Ph.D in Molecular and Cellular Genetics, University of Naples ‘Federico II’, Italy, 2012

Current position

Group Leader at CROM (Oncology Research Center of Mercogliano), National Cancer Institute of Naples, Pascale Foundation, Italy
Adjunct Associate Professor, Sbarro Institute for Cancer Research and Molecular Medicine and Center of Biotechnology, College of Science and Technology, Department of Biology, Temple University, Philadelphia, PA, USA

Publications (since 2005)

  1. Drago-Ferrante, R., Pentimalli, F., Carlisi, D., De Blasio, A., Saliba, C., Baldacchino, S., Degaetano, J., Debono, J., Caruana-Dingli, G., Grech, G., Scerri, C., Tesoriere, G., Giordano, A., Vento, R. and Di Fiore, R. (2017). Suppressive role exerted by microRNA-29b-1-5p in triple negative breast cancer through SPIN1 regulation. Oncotarget 8(17): 28939-28958.
  2. Petrella, F., Cocce, V., Masia, C., Milani, M., Sale, E. O., Alessandri, G., Parati, E., Sisto, F., Pentimalli, F., Brini, A. T., Pessina, A. and Spaggiari, L. (2017). Paclitaxel-releasing mesenchymal stromal cells inhibit in vitro proliferation of human mesothelioma cells. Biomed Pharmacother 87: 755-758.
  3. Altobelli, G. G., Pentimalli, F., D'Armiento, M., Van Noorden, S. and Cimini, V. (2017). Calretinin Immunoreactivity in the Human Testis Throughout Fetal Life. J Cell Physiol 232(7): 1872-1878.
  4. Cimini, A., d'Angelo, M., Benedetti, E., D'Angelo, B., Laurenti, G., Antonosante, A., Cristiano, L., Di Mambro, A., Barbarino, M., Castelli, V., Cinque, B., Cifone, M. G., Ippoliti, R., Pentimalli, F. and Giordano, A. (2017). Flavopiridol: An Old Drug With New Perspectives? Implication for Development of New Drugs. J Cell Physiol 232(2): 312-322.
  5. Indovina, P., Casini, N., Forte, I. M., Garofano, T., Cesari, D., Iannuzzi, C. A., Del Porro, L., Pentimalli, F., Napoliello, L., Boffo, S., Schenone, S., Botta, M. and Giordano, A. (2017). SRC Family Kinase Inhibition in Ewing Sarcoma Cells Induces p38 MAP Kinase-Mediated Cytotoxicity and Reduces Cell Migration. J Cell Physiol 232(1): 129-135.
  6. Alfano, L., Costa, C., Caporaso, A., Antonini, D., Giordano, A. and Pentimalli, F. (2016). HUR protects NONO from degradation by mir320, which is induced by p53 upon UV irradiation. Oncotarget 7(47): 78127-78139.
  7. Di Fiore, R., Drago-Ferrante, R., Pentimalli, F., Di Marzo, D., Forte, I. M., Carlisi, D., De Blasio, A., Tesoriere, G., Giordano, A. and Vento, R. (2016). Let-7d miRNA Shows Both Antioncogenic and Oncogenic Functions in Osteosarcoma-Derived 3AB-OS Cancer Stem Cells. J Cell Physiol 231(8): 1832-1841.
  8. Alfano, L., Costa, C., Caporaso, A., Altieri, A., Indovina, P., Macaluso, M., Giordano, A. and Pentimalli, F. (2016). NONO regulates the intra-S-phase checkpoint in response to UV radiation. Oncogene 35(5): 567-576.
  9. Ussai, S., Petelin, R., Giordano, A., Malinconico, M., Cirillo, D. and Pentimalli, F. (2015). A pilot study on the impact of known drug-drug interactions in cancer patients. J Exp Clin Cancer Res 34: 89.
  10. Indovina, P., Pentimalli, F., Casini, N., Vocca, I. and Giordano, A. (2015). RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy. Oncotarget 6(20): 17873-17890.
  11. Casini, N., Forte, I. M., Mastrogiovanni, G., Pentimalli, F., Angelucci, A., Festuccia, C., Tomei, V., Ceccherini, E., Di Marzo, D., Schenone, S., Botta, M., Giordano, A. and Indovina, P. (2015). SRC family kinase (SFK) inhibition reduces rhabdomyosarcoma cell growth in vitro and in vivo and triggers p38 MAP kinase-mediated differentiation. Oncotarget 6(14): 12421-12435.
  12. Ceccherini, E., Indovina, P., Zamperini, C., Dreassi, E., Casini, N., Cutaia, O., Forte, I. M., Pentimalli, F., Esposito, L., Polito, M. S., Schenone, S., Botta, M. and Giordano, A. (2015). SRC family kinase inhibition through a new pyrazolo[3,4-d]pyrimidine derivative as a feasible approach for glioblastoma treatment. J Cell Biochem 116(5): 856-863.
  13. Cito, L., Indovina, P., Forte, I. M., Pentimalli, F., Di Marzo, D., Somma, P., Barone, D., Penon, A., Penon, D., Ceccherini, E., Micheli, P., Saragoni, L., Di Domenico, M., Feola, A., Roviello, F., Mattioli, E., Giordano, G. G. and Giordano, A. (2015). pRb2/p130 localizes to the cytoplasm in diffuse gastric cancer. J Cell Physiol 230(4): 802-805.
  14. Di Fiore, R., Drago-Ferrante, R., Pentimalli, F., Di Marzo, D., Forte, I. M., D'Anneo, A., Carlisi, D., De Blasio, A., Giuliano, M., Tesoriere, G., Giordano, A. and Vento, R. (2014). MicroRNA-29b-1 impairs in vitro cell proliferation, selfrenewal and chemoresistance of human osteosarcoma 3AB-OS cancer stem cells. Int J Oncol 45(5): 2013-2023.
  15. Fiorelli, A., Pentimalli, F., D'Urso, V., Di Marzo, D., Forte, I. M., Giordano, A., Di Domenico, M., Accardo, M., Di Serio, U. and Santini, M. (2014). Antineoplastic activity of povidone-iodine on different mesothelioma cell lines: results of in vitro study. Eur J Cardiothorac Surg 45(6): 993-1000.
  16. Indovina, P., Marcelli, E., Di Marzo, D., Casini, N., Forte, I. M., Giorgi, F., Alfano, L., Pentimalli, F. and Giordano, A. (2014). Abrogating G(2)/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma. Cancer Biol Ther 15(4): 380-388.
  17. Di Marzo, D., Forte, I. M., Indovina, P., Di Gennaro, E., Rizzo, V., Giorgi, F., Mattioli, E., Iannuzzi, C. A., Budillon, A., Giordano, A. and Pentimalli, F. (2014). Pharmacological targeting of p53 through RITA is an effective antitumoral strategy for malignant pleural mesothelioma. Cell Cycle 13(4): 652-665.
  18. Abate, A. A., Pentimalli, F., Esposito, L. and Giordano, A. (2013). ATP-noncompetitive CDK inhibitors for cancer therapy: an overview. Expert Opin Investig Drugs 22(7): 895-906.
  19. Capasso, I., Esposito, E., Pentimalli, F., Montella, M., Crispo, A., Maurea, N., D'Aiuto, M., Fucito, A., Grimaldi, M., Cavalcanti, E., Esposito, G., Brillante, G., Lodato, S., Pedicini, T., D'Aiuto, G., Ciliberto, G. and Giordano, A. (2013). Homeostasis model assessment to detect insulin resistance and identify patients at high risk of breast cancer development: National Cancer Institute of Naples experience. J Exp Clin Cancer Res 32: 14.
  20. Vocca, I., Muzi, G., Pentimalli, F. and Giordano, A. (2012). CCNA1 (cyclin A1). Atlas Genet Cytogenet Oncol Haematol.
  21. Piscitelli, P., Barba, M., Crespi, M., Di Maio, M., Santoriello, A., D'Aiuto, M., Fucito, A., Losco, A., Pentimalli, F., Maranta, P., Chitano, G., Argentiero, A., Neglia, C., Distante, A., Di Tanna, G. L., Brandi, M. L., Mazza, A., Marino, I. R., Giordano, A. and Human Health Foundation Study Group, i. m. o. P. G. G. G. (2012). The burden of breast cancer in Italy: mastectomies and quadrantectomies performed between 2001 and 2008 based on nationwide hospital discharge records. J Exp Clin Cancer Res 31: 96.
  22. Di Fiore, R., Guercio, A., Puleio, R., Di Marco, P., Drago-Ferrante, R., D'Anneo, A., De Blasio, A., Carlisi, D., Di Bella, S., Pentimalli, F., Forte, I. M., Giordano, A., Tesoriere, G. and Vento, R. (2012). Modeling human osteosarcoma in mice through 3AB-OS cancer stem cell xenografts. J Cell Biochem 113(11): 3380-3392.
  23. Indovina, P., Marcelli, E., Pentimalli, F., Tanganelli, P., Tarro, G. and Giordano, A. (2013). Mass spectrometry-based proteomics: the road to lung cancer biomarker discovery. Mass Spectrom Rev 32(2): 129-142.
  24. Esposito, C., Di Spirito, A., Cuomo, N., Di Nicuolo, G., Flaminio, G., Altamura, F., Ambrosino, D., Cantalupo, F., Costa, C., Pentimalli, F. and Tarro, G. (2012). Tracking the 2009 H1N1 influenza virus in the Italian region Campania. J Cell Physiol 227(7): 2813-2817.
  25. Cozzi, M., Giorgi, F., Marcelli, E., Pentimalli, F., Forte, I. M., Schenone, S., D'Urso, V., De Falco, G., Botta, M., Giordano, A. and Indovina, P. (2012). Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition. Cell Cycle 11(5): 1029-1039.
  26. Indovina, P., Giorgi, F., Rizzo, V., Khadang, B., Schenone, S., Di Marzo, D., Forte, I. M., Tomei, V., Mattioli, E., D'Urso, V., Grilli, B., Botta, M., Giordano, A. and Pentimalli, F. (2012). New pyrazolo[3,4-d]pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization. Oncogene 31(7): 929-938.
  27. Cirillo, D., Pentimalli, F. and Giordano, A. (2011). Peptides or small molecules? Different approaches to develop more effective CDK inhibitors. Curr Med Chem 18(19): 2854-2866.
  28. Pentimalli, F., Indovina, P. and Giordano, A. (2010). Retinoblastoma beyond RB1 — recent advances in genetic biomarkers. Expert Rev Ophtalmol 5(6):717-721.
  29. Napoli, C., Giordano, A., Casamassimi, A., Pentimalli, F., Ignarro, L. J. and De Nigris, F. (2011). Directed in vivo angiogenesis assay and the study of systemic neoangiogenesis in cancer. Int J Cancer 128(7): 1505-1508.
  30. Capasso, I., Esposito, E., Pentimalli, F., Crispo, A., Montella, M., Grimaldi, M., De Marco, M., Cavalcanti, E., D'Aiuto, M., Fucito, A., Frasci, G., Maurea, N., Esposito, G., Pedicini, T., Vecchione, A., D'Aiuto, G. and Giordano, A. (2010). Metabolic syndrome affects breast cancer risk in postmenopausal women: National Cancer Institute of Naples experience. Cancer Biol Ther 10(12): 1240-1243.
  31. Cito, L., Pentimalli, F., Forte, I., Mattioli, E. and Giordano, A. (2010). Rb family proteins in gastric cancer (review). Oncol Rep 24(6): 1411-1418.
  32. de Nigris, F., Crudele, V., Giovane, A., Casamassimi, A., Giordano, A., Garban, H. J., Cacciatore, F., Pentimalli, F., Marquez-Garban, D. C., Petrillo, A., Cito, L., Sommese, L., Fiore, A., Petrillo, M., Siani, A., Barbieri, A., Arra, C., Rengo, F., Hayashi, T., Al-Omran, M., Ignarro, L. J. and Napoli, C. (2010). CXCR4/YY1 inhibition impairs VEGF network and angiogenesis during malignancy. Proc Natl Acad Sci U S A 107(32): 14484-14489.
  33. Rossi, A., Schenone, S., Angelucci, A., Cozzi, M., Caracciolo, V., Pentimalli, F., Puca, A., Pucci, B., La Montagna, R., Bologna, M., Botta, M. and Giordano, A. (2010). New pyrazolo-[3,4-d]-pyrimidine derivative Src kinase inhibitors lead to cell cycle arrest and tumor growth reduction of human medulloblastoma cells. FASEB J 24(8): 2881-2892.
  34. Mattioli, E., Giordano, A. and Pentimalli, F. (2010). Predicting breast cancer outcome: traditional prognosticators still on center stage. Cancer Biol Ther 9(4): 274-276.
  35. Indovina, P., Acquaviva, A., De Falco, G., Rizzo, V., Onnis, A., Luzzi, A., Giorgi, F., Hadjistilianou, T., Toti, P., Tomei, V., Pentimalli, F., Carugi, A. and Giordano, A. (2010). Downregulation and aberrant promoter methylation of p16INK4A: a possible novel heritable susceptibility marker to retinoblastoma. J Cell Physiol 223(1): 143-150.
  36. Pentimalli, F. and Giordano, A. (2009). Promises and drawbacks of targeting cell cycle kinases in cancer. Discov Med 8(43): 177-180.
  37. Romano, G., Marino, I. R., Pentimalli, F., Adamo, V. and Giordano, A. (2009). Insertional mutagenesis and development of malignancies induced by integrating gene delivery systems: implications for the design of safer gene-based interventions in patients. Drug News Perspect 22(4): 185-196.
  38. Rossi, A., Russo, G., Puca, A., La Montagna, R., Caputo, M., Mattioli, E., Lopez, M., Giordano, A. and Pentimalli, F. (2009). The antiretroviral nucleoside analogue Abacavir reduces cell growth and promotes differentiation of human medulloblastoma cells. Int J Cancer 125(1): 235-243.
  39. Pentimalli, F., Palmieri, D., Pacelli, R., Garbi, C., Cesari, R., Martin, E., Pierantoni, G. M., Chieffi, P., Croce, C. M., Costanzo, V., Fedele, M. and Fusco, A. (2008). HMGA1 protein is a novel target of the ATM kinase. Eur J Cancer 44(17): 2668-2679.
  40. Pentimalli, F. and Giordano, A. (2008). Inducing the uptake of the deadly executioner in cancer cells. Cancer Biol Ther 7(6): 955-957.
  41. Visconti, R., Federico, A., Coppola, V., Pentimalli, F., Berlingieri, M. T., Pallante, P., Kruhoffer, M., Orntoft, T. F. and Fusco, A. (2007). Transcriptional profile of Ki-Ras-induced transformation of thyroid cells. Cancer Invest 25(4): 256-266.
  42. Merolla, F., Pentimalli, F., Pacelli, R., Vecchio, G., Fusco, A., Grieco, M. and Celetti, A. (2007). Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage. Oncogene 26(42): 6167-6175.
  43. Bifulco, M., Laezza, C., Gazzerro, P. and Pentimalli, F. (2007). Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (review). Oncol Rep 17(4): 813-816.
  44. Fedele, M., Fidanza, V., Battista, S., Pentimalli, F., Klein-Szanto, A. J., Visone, R., De Martino, I., Curcio, A., Morisco, C., Del Vecchio, L., Baldassarre, G., Arra, C., Viglietto, G., Indolfi, C., Croce, C. M. and Fusco, A. (2006). Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice. Cancer Res 66(5): 2536-2543.
  45. Baldassarre, G., Belletti, B., Battista, S., Nicoloso, M. S., Pentimalli, F., Fedele, M., Croce, C. M. and Fusco, A. (2005). HMGA1 protein expression sensitizes cells to cisplatin-induced cell death. Oncogene 24(45): 6809-6819.
  46. Battista, S., Fedele, M., Martinez Hoyos, J., Pentimalli, F., Pierantoni, G.M., Visone, R., De Martino, I., Croce, C.M. and Fusco, A. (2005). High Mobility Group A1 proteins downregulate RAG2 gene expression. Biochem J 389(Pt 1): 91-97.
  47. Fedele, M., Pentimalli, F., Baldassarre, G., Battista, S., Klein-Szanto, A. J., Kenyon, L., Visone, R., De Martino, I., Ciarmiello, A., Arra, C., Viglietto, G., Croce, C. M. and Fusco, A. (2005). Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas. Oncogene 24(21): 3427-3435.
  48. Sarti, M., Sevignani, C., Calin, G. A., Aqeilan, R., Shimizu, M., Pentimalli, F., Picchio, M. C., Godwin, A., Rosenberg, A., Drusco, A., Negrini, M. and Croce, C. M. (2005). Adenoviral transduction of TESTIN gene into breast and uterine cancer cell lines promotes apoptosis and tumor reduction in vivo. Clin Cancer Res 11(2 Pt 1): 806-813.
1 Protocol published
DNA Fiber Assay upon Treatment with Ultraviolet Radiations
Authors:  Alfano Luigi, Antonio Giordano and Francesca Pentimalli, date: 06/05/2017, view: 11169, Q&A: 0
Genome stability is continuously challenged by a wide range of DNA damaging factors. To promote a correct DNA repair and cell survival, cells orchestrate a coordinated and finely tuned cascade of events collectively known as the DNA Damage Response ...
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