Alka Mehra Institute of Genomics and Integrative Biology
39 protocols

Andrea Puhar MIMS and Department of Molecular Biology, Umeå University
52 protocols

Fanny Ehret German Center for Neurodegenerative Diseases Dresden
4 protocols

Gal Haimovich Molecular Genetics, Weizmann Institute of Science, Israel
95 protocols

Reviewer
Alexandros C Kokotos
  • Post-Doc, Weill Cornell Medicine
Research focus
  • Neuroscience
  • Synaptic vesicle recycling
    Endocytosis
    Neurotransmission
    Rab GTPases
    Synaptic endosomes
    Synaptic metabolism
    GLUT4 trafficking

Education

PhD, University of Edinburgh, 2017

Lab information

Prof. Timothy Ryan's lab
https://sites.google.com/site/ryanlab1/Home

Publications

https://www.ncbi.nlm.nih.gov/pubmed/?term=kokotos+ac
Kokotos, A.C., Harper, C.B., Marland, J.R.K., Smillie, K.J., Cousin, M.A., and Gordon, S.L. (2019). Synaptophysin sustains presynaptic performance by preserving vesicular synaptobrevin-II levels. J. Neurochem 151, 28-37.

Kokotos, A.C., Peltier, J., Davenport, E.C., Trost, M., and Cousin, M.A. (2018). Activity dependent bulk endocytosis proteome reveals a key presynaptic role for the monomeric GTPase Rab11. Proceedings of the National Academy of Sciences, 201809189.

Peiris, H., Duffield, M.D., Fadista, J., Jessup, C.F., Kashmir, V., Genders, A.J., McGee, S.L., Martin, A.M., Saiedi, M., Morton, N., Carter, R., Cousin, M.A., Kokotos, A.C., Oskolkov, N., Volkov, P., Hough, T.A., Fisher, E.M., Tybulewicz, V.L., Busciglio, J., Coskun, P.E., Becker, A., Belichenko, P.V., Mobley, W.C., Ryan, M.T., Chan, J.Y., Laybutt, D.R., Coates, P.T., Yang, S., Ling, C., Groop, L., Pritchard, M.A., and Keating, D.J. (2016). A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to beta-Cell Mitochondrial Dysfunction in Type 2 Diabetes. PLoS genetics 12, e1006033.

Nicholson-Fish, J.C., Kokotos, A.C., Gillingwater, T.H., Smillie, K.J., and Cousin, M.A. (2015). VAMP4 Is an Essential Cargo Molecule for Activity-Dependent Bulk Endocytosis. Neuron 88, 973-984.

Kokotos, A.C., and Low, D.W. (2015). Myosin II and Dynamin Control Actin Rings to Mediate Fission during Activity-Dependent Bulk Endocytosis. The Journal of neuroscience 35, 8687-8688.

Kokotos, A.C., and Cousin, M.A. (2015). Synaptic vesicle generation from central nerve terminal endosomes. Traffic 16, 229-240.

Karachaliou, M., Amillis, S., Evangelinos, M., Kokotos, A.C., Yalelis, V., and Diallinas, G. (2013). The arrestin-like protein ArtA is essential for ubiquitination and endocytosis of the UapA transporter in response to both broad-range and specific signals. Molecular microbiology 88, 301-317.
16 Protocols reviewed
Ex vivo Assessment of Mitochondrial Function in Human Peripheral Blood Mononuclear Cells Using XF Analyzer
Authors:  Alica Schöller-Mann, Katja Matt, Barbara Hochecker and Jörg Bergemann, date: 04/05/2021, view: 264, Q&A: 0

Cellular health and function, as we know today, depend on a large extent on mitochondrial function. The essential function of mitochondria is the energy production, more precisely ATP production, via oxidative phosphorylation. Mitochondrial energy

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Ligand and Carbohydrate Engagement (LACE) Assay and Fluorescence Quantification on Murine Neural Tissue
Authors:  James M. Clegg and Thomas Pratt, date: 03/20/2021, view: 478, Q&A: 0

The interaction between cell surface heparan sulphate and diffusible ligands such as FGFs is of vital importance for downstream signaling, however, there are few techniques that can be used to investigate this binding event. The ligand and

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