4 protocols

Imane Hurel U1215 INSERM Neurocentre Magendie, University of Bordeaux, 2018-
1 protocol

Bastien Redon INSERM U1215 Neurocentre Magendie
1 protocol

Francis Chaouloff
  • PI, Endocannabinoids & NeuroAdaptation, Neurocentre INSERM U1215 Bordeaux
Research focus
  • -
  • 1 Author merit


PhD, Paris University, France, 1985


Since 2000
• Hurel I, Redon B, Scocard A, Malezieux M, Marsicano G, Chaouloff F. Beyond the activity-based anorexia model: reinforcing values of exercise and feeding examined in stressed adolescent male and female mice. Front. Pharmacol. 2019 10:587.
• Muguruza C, Redon B, Fois GR, Hurel I, Scocard A, Nguyen C, Stevens C, Soria-Gomez E, Varilh M, Cannich A, Daniault J, Busquets-Garcia A, Pelliccia T, Caillé S, Georges F, Marsicano G, Chaouloff F. The motivation for exercise over palatable food is dictated by cannabinoid type-1 receptors. J. Clin. Invest. Insight 2019; 4(5) pii 126190.
• Busquets-Garcia A, Soria-Gómez E, Redon B, Mackenbach Y, Vallée M, Chaouloff F, Varilh M, Ferreira G, Piazza PV, Marsicano G. Pregnenolone blocks cannabinoid-induced acute psychotic-like states in mice. Mol. Psychiatry 2017; 22(11):1594-1603.
• Baggelaar MP, van Esbroeck A, van Rooden E, Florea BI, Overkleeft HS, Marsicano G, Chaouloff F, van der Stelt M. Chemical proteomics maps brain region specific activity of endocannabinoid hydrolases. ACS Chem. Biol. 2017; 12(3):852-861.
• Dostes S, Dubreucq S, Ladevèze E, Marsicano G, Abrous DN, Chaouloff F*, Koehl M*. Running per se stimulates the dendritic arbor of newborn dentate granule cells in mouse hippocampus in a duration-dependent manner. Hippocampus. 2016; 26(3):282-288.
• Belluomo I, Matias I, Pernègre C, Marsicano G, Chaouloff F. Opposite control of frontocortical 2-arachidonoylglycerol turnover rate by cannabinoid type-1 (CB1 ) receptors located on glutamatergic neurons and on astrocytes. J Neurochem. 2015; 133(1) :26-37.
• Gray JM, Chaouloff F, Hill MN. To stress or not to stress: a question of models. Curr. Protoc. Neurosci. 2015; 70:8.33.1-8.33.22.
• Dubreucq S, Marsicano G, Chaouloff F. Duration- and environment-dependent effects of repeated voluntary exercise on anxiety and cued fear in mice. Behav. Brain Res. 2015; 282(1):1-5.
• Hebert-Chatelain E, Reguero L, Puente N, Lutz B, Chaouloff F, Rossignol R, Piazza PV, Benard G, Grandes P, Marsicano G. Cannabinoid control of brain bioenergetics: Exploring the subcellular localization of the CB1 receptor. Mol Metab. 2014; 3(4):495-504.
• Hebert-Chatelain E, Reguero L, Puente N, Lutz B, Chaouloff F, Rossignol R, Piazza PV, Benard G, Grandes P, Marsicano G. Studying mitochondrial CB1 receptors: Yes we can. Mol Metab. 2014; 3(4):339.
• Glangetas C, Girard D, Groc L, Marsicano G, Chaouloff F*, Georges F*. Stress switches cannabinoid type-1 (CB1) receptor-dependent plasticity from LTD to LTP in the bed nucleus of the stria terminalis. J. Neurosci. 2013; 33(50):19657-19663.
• Dubreucq S, Durand A, Matias I, Bénard G, Richard E, Soria-Gomez E, Glangetas C, Groc L, Wadleigh A, Massa F, Bartsch D, Marsicano G, Georges F, Chaouloff F. Ventral tegmental area cannabinoid type-1 receptors control voluntary exercise performance. Biol. Psychiatry 2013; 73(9):895-903.
• Bellocchio L, Soria-Gómez E, Quarta C, Metna-Laurent M, Cardinal P, Binder E, Cannich A, Delamarre A, Häring M, Martín-Fontecha M, Vega D, Leste-Lasserre T, Bartsch D, Monory K, Lutz B, Chaouloff F, Pagotto U, Guzman M, Cota D, Marsicano G. Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB1 receptor blockade. Proc. Natl Acad. Sci. USA 2013; 110(12):4786-4791.
• Zhang H, Etherington LA, Hafner AS, Belelli D, Coussen F, Delagrange P, Chaouloff F, Spedding M, Lambert JJ, Choquet D, Groc L. Regulation of AMPA receptor surface trafficking and synaptic plasticity by a cognitive enhancer and antidepressant molecule. Mol. Psychiatry 2013; 18(4):471-484.
• Dubreucq S, Matias I, Cardinal P, Häring M, Lutz B, Marsicano G, Chaouloff F. Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice. Neuropsychopharmacology 2012; 37(8):1885-1900.
• Bénard G, Massa F, Puente N, Lourenço J, Bellocchio L, Soria-Gómez E, Matias I, Delamarre A, Metna-Laurent M, Cannich A, Hebert-Chatelain E, Mulle C, Ortega-Gutiérrez S, Martín-Fontecha M, Klugmann M, Guggenhuber S, Lutz B, Gertsch J, Chaouloff F, López-Rodríguez ML, Grandes P, Rossignol R, Marsicano G. Mitochondrial CB1 receptors regulate neuronal energy metabolism. Nat. Neurosci. 2012; 15(4):558-564.
• Marsicano G, Chaouloff F. Moving bliss: a new anandamide transporter. Nat. Neurosci. 201; 15(1):5-6.
• Dubreucq S, Kambire S, Conforzi M, Metna-Laurent M, Cannich A, Soria-Gomez E, Richard E, Marsicano G, Chaouloff F. Cannabinoid type 1 receptors located on single-minded 1-expressing neurons control emotional behaviors. Neuroscience 2012; 204:230-244.
• Chaouloff F, Dubreucq S, Bellocchio L, Marsicano G. Endocannabinoids and motor behavior: CB1 receptors also control running activity. Physiology 2011; 26(2):76-77.
• Chaouloff F., Groc L. Temporal effects of corticosteroids and stress on hippocampal excitatory transmission. Front. Neuroendocrinology 2011; 32(1):25-42.
• Dubreucq S, Marsicano G, Chaouloff F. Emotional Consequences of Wheel Running in Mice: Which is the Appropriate Control? Hippocampus 2011; 21(3):239-242.
• Dubreucq S, Koehl M, Abrous DN, Marsicano G, Chaouloff F. CB1 receptor deficiency decreases wheel-running activity: Consequences on emotional behaviours and hippocampal neurogenesis. Exp Neurol. 2010; 224(1):106-113.
• Bellocchio L, Lafenêtre P, Cannich A, Cota D, Puente N, Grandes P, Chaouloff F, Piazza PV, Marsicano G.
• Bimodal control of stimulated food intake by the endocannabinoid system. Nature Neurosci. 2010; 13(3):281-283.
• Lafenêtre P, Chaouloff F, Marsicano G. Bidirectional regulation of novelty-induced behavioral inhibition by the endocannabinoid system. Neuropharmacology. 2009; 57(7-8):715-721
• Groc L, Choquet D, Chaouloff F. The stress hormone corticosterone conditions AMPA receptor surface trafficking and synaptic potentiation. Nature Neurosci. 2008; 11(8):868-870.
• Groc L, Chaouloff F. New insights in stress-induced synaptic adaptations. Méd. Sci. 2008; 24(8-9):776-778.
• Chaouloff F, Hémar A, Manzoni, O. Local facilitation of hippocampal metabotropic glutamate receptor-dependent long-term depression by corticosterone and dexamethasone.Psychoneuroendocrinology 2008; 33(5):686-691.
• Chaouloff F, Hémar A, Manzoni O. Acute stress facilitates hippocampal CA1 metabotropic glutamate receptor-dependent long-term depression. J. Neurosci. 2007;27(27):7130-7135.
• Durand M, Mormède P, Chaouloff F. Wistar-Kyoto rats are sensitive to the hypolocomotor and anxiogenic effects of mCPP. Behav. Pharmacol. 2003;14(2):173-177.
• Fernandez F, Sarre S, Launay JM, Aguerre S, Guyonnet-Dupérat V, Moisan MP, Ebinger G, Michotte Y, Mormède P, Chaouloff F. Rat strain differences in peripheral and central serotonin transporter protein expression and function. Eur. J. Neurosci. 2003;17(3):494-506.
• Dias Soares D, Fernandez F, Aguerre S, Foury A, Mormède P, Chaouloff F. Fox odour affects corticosterone release but not hippocampal serotonin reuptake and open field behaviour in rats. Brain Res. 2003;961(1):166-170.
• Fernandez F, Porras G, Mormède P, Spampinato U, Chaouloff F. Effects of 3,4-methylenedioxymethamphetamine on locomotor activity and extracellular dopamine in the nucleus accumbens of Fischer 344 and Lewis rats. Neurosci. Lett. 2003;335(3):212-216.
• Mormède P, Moneva E, Bruneval C, Chaouloff F, Moisan MP. Marker-assisted selection of a neuro-behavioural trait related to behavioural inhibition in the SHR strain, an animal model of ADHD. Genes Brain Behav. 2002;1(2):111-116.
• Fernandez F, Aguerre S, Mormède P, Chaouloff F. Influences of the corticotropic axis and sympathetic activity on neurochemical consequences of 3,4-methylenedioxymethamphetamine (MDMA) administration in Fischer 344 rats. Eur. J. Neurosci. 2002;16(4):607-618.
• Baudrie V, Laude D, Chaouloff F, Elghozi JL. Genetic influences on cardiovascular responses to an acoustic startle stimulus in rats. Clin. Exp. Pharmacol. Physiol. 2001; 28(12):1096-1099.
• Duclos M, Martin C, Malgat M, Mazat JP, Chaouloff F, Mormède P, Letellier T. Relationships between muscle mitochondrial metabolism and stress-induced corticosterone variations in rats. Pflugers Arch. 2001; 443(2):218-226.
• Chaouloff F. Sympathomimetic effects of pindolol in depression. Trends Pharmacol. Sci. 2001; 22(11):554-555.
• Fernandez F, Aguerre S, Mormède P, Chaouloff F. Differential sensitivities to the lethal, but not the neurotoxic, effects of p-chloroamphetamine in inbred rat strains. Neurosci Lett. 2001;297(1):53-57.
• Takahashi RN, Berton O, Mormède P, Chaouloff F. Strain-dependent effects of diazepam and the 5-HT2B/2C receptor antagonist SB 206553 in spontaneously hypertensive and Lewis rats tested in the elevated plus-maze. Braz. J. Med. Biol. Res. 2001; 34(5):675-682.
• Fernandez F, Aguerre S, Mormède P, Chaouloff F. Effects of corticosterone ingestion on hippocampal [3H]serotonin reuptake in inbred rat strains. Endocrine Reg. 35(2):119-126.
• Durand M, Aguerre S, Fernandez F, Edno L, Combourieu I, Mormède P, Chaouloff F. Strain-dependent neurochemical and neuroendocrine effects of desipramine, but not fluoxetine or imipramine, in Spontaneously Hypertensive and Wistar-Kyoto rats.
• Neuropharmacology 2000;39(12):2464-2477.
• Martin C, Duclos M, Mormède P, Manier G, Chaouloff F. Hippocampal and striatal [3H]5-HT reuptake under acute stressors in two rat strains differing for their emotivity. Neurosci Lett. 2000;288(3):246-248.
• Martin CL, Duclos M, Aguerre S, Mormède P, Manier G, Chaouloff F. Corticotropic and serotonergic responses to acute stress with/without prior exercise training in different rat strains. Acta Physiol Scand. 2000;168(3):421-430.
• Pollier F, Sarre S, Aguerre S, Ebinger G, Mormède P, Michotte Y, Chaouloff F. Serotonin reuptake inhibition by citalopram in rat strains differing for their emotionality. Neuropsychopharmacology 2000;22(1):64-76.

• Gray JM, Chaouloff F, Hill MN. To stress or not to stress : a question of models. Curr. Protoc. Neurosci. 2015; 70 :8.33.1-8.33.22
• Chaouloff F. Social stress models in depression research : what do they tell us ? Cell Tissue Res. 2013; 354(1) :179-190.
• Chaouloff F, Groc L. Temporal effects of corticosteroids and stress on hippocampal excitatory transmission. Front. Neuroendocrinology 2011; 32(1) : 25-42.
• Lafenêtre P, Chaouloff F, Marsicano G. The endocannabinoid system in the processing of anxiety and fear and how CB1 receptors may modulate fear extinction. Pharmacol Res. 2007;56(5):367-381.
• Mormède P, Courvoisier H, Ramos A, Marissal-Arvy N, Ousova O, Desautés C, Duclos M, Chaouloff F, Moisan MP. Molecular genetic approaches to investigate individual variations in behavioral and neuroendocrine stress responses. Psychoneuroendocrinology. 2002;27(5):563-83.

Book chapters
• Chaouloff F, Dubreucq S, Matias I, Marsicano G. Physical feel-good effect. The role of endocannabinoids. In "Routledge Handbook of Physical Activity and Mental Health", editor : EKKEKAKIS, P., Taylor and Francis (New York), 2013, pp 71-87.
1 Protocol published
An Operant Conditioning Task to Assess the Choice between Wheel Running and Palatable Food in Mice
Authors:  Bastien Redon, Imane Hurel, Giovanni Marsicano and Francis Chaouloff, date: 10/05/2019, view: 248, Q&A: 0
Wheel running, especially in the homecage, has been widely used to study the neurobiology of exercise because animal tends to use it voluntarily. However, as for each reward, its consumption (in the present case, running performance) does not ...
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