Anita Umesh Illumina
4 protocols

Gal Haimovich Molecular Genetics, Weizmann Institute of Science, Israel
93 protocols

Hong Lian Institute of Neuroscience, Zhejiang University School of Medicine, China
1 protocol

Joshua Titlow 2 protocols

Karthik Krishnamurthy
  • Post-Doc, Thomas Jefferson University
Research focus
  • Neuroscience
  • Cell Biology, Neuronal cultures, live cell imaging, calcium signaling, microscopy, stress granules, Neurodegeneration, ALS, neuromuscular junction, synaptic dysfunction,


PhD, National Institute of Mental Health and Neurosciences (NIMHANS), India, 2012

Lab information

Dr Piera Pasinelli lab, Jefferson Weinberg ALS Center

1. Casci I, Krishnamurthy K*, Kour S, Tripathy V, Ramesh N, Anderson EN, Marrone L,
Grant RA, Oliver S, Gochenaur L, Patel K, Sterneckert J, Gleixner AM, Donnelly
CJ, Ruepp MD, Sini AM, Zuccaro E, Pennuto M, Pasinelli P, Pandey UB. Muscleblind
acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN
localization. Nat Commun. 2019 Dec 6;10(1):5583. doi: 10.1038/s41467-019-13383-z.
PubMed [citation] PMID: 31811140, PMCID: PMC6898697

2. Charsar BA, Brinton MA, Locke K, Chen AY, Ghosh B, Urban MW, Komaravolu S,
Krishnamurthy K, Smit R, Pasinelli P, Wright MC, Smith GM, Lepore AC. AAV2-BDNF
promotes respiratory axon plasticity and recovery of diaphragm function following
spinal cord injury. FASEB J. 2019 Dec;33(12):13775-13793. doi:
10.1096/fj.201901730R. Epub 2019 Oct 2. PubMed [citation] PMID: 31577916, PMCID:

3. Kia A, McAvoy K, Krishnamurthy K, Trotti D, Pasinelli P. Astrocytes expressing
ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis
factor-alpha. Glia. 2018 May;66(5):1016-1033. doi: 10.1002/glia.23298. Epub 2018
Jan 30. PubMed [citation] PMID: 29380416, PMCID: PMC5873384

4. Daigle JG, Krishnamurthy K*, Ramesh N, Casci I, Monaghan J, McAvoy K, Godfrey EW,
Daniel DC, Johnson EM, Monahan Z, Shewmaker F, Pasinelli P, Pandey UB. Pur-alpha
regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity. Acta
Neuropathol. 2016 Apr;131(4):605-20. doi: 10.1007/s00401-015-1530-0. Epub 2016
Jan 4. PubMed [citation] PMID: 26728149, PMCID: PMC4791193

5. Wen X, Tan W, Westergard T, Krishnamurthy K, Markandaiah SS, Shi Y, Lin S,
Shneider NA, Monaghan J, Pandey UB, Pasinelli P, Ichida JK, Trotti D. Antisense
proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear
aggregates that initiate in vitro and in vivo neuronal death. Neuron. 2014 Dec
17;84(6):1213-25. doi: 10.1016/j.neuron.2014.12.010. PubMed [citation] PMID:
25521377, PMCID: PMC4632245

6. Krishnamurthy K, Mehta B, Singh M, Tewari BP, Joshi PG, Joshi NB.
Depalmitoylation preferentially downregulates AMPA induced Ca2+ signaling and
neurotoxicity in motor neurons. Brain Res. 2013 Sep 5;1529:143-53. doi:
10.1016/j.brainres.2013.06.039. Epub 2013 Jul 10. PubMed [citation] PMID:

7. Joshi DC, Singh M, Krishnamurthy K, Joshi PG, Joshi NB. AMPA induced Ca2+ influx
in motor neurons occurs through voltage gated Ca2+ channel and Ca2+ permeable
AMPA receptor. Neurochem Int. 2011 Nov;59(6):913-21. doi:
10.1016/j.neuint.2011.06.023. Epub 2011 Jul 13. PubMed [citation] PMID: 21777635
8 Protocols reviewed
Time-lapse Imaging of Alveologenesis in Mouse Precision-cut Lung Slices
Alveoli are the gas-exchange units of lung. The process of alveolar development, alveologenesis, is regulated by a complex network of signaling pathways that act on various cell types including alveolar type I and II epithelial cells, fibroblasts ...
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Partial Transection of Adult Rat Optic Nerve as a Model of Secondary Degeneration in the Central Nervous System
Authors:  Carole A Bartlett and Melinda Fitzgerald, date: 12/20/2018, view: 2043, Q&A: 0
Injury to the central nervous system is characterized by damage that spreads from the initial point of impact into the surrounding adjacent tissue, in a phenomenon referred to as secondary degeneration. The optic nerve can be used to effectively ...
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