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Coauthors
Zhe Han Center for Cancer and Immunology Research, Children’s National Medical Center, USA
1 protocol

Adam Richman Center for Cancer and Immunology Research, Children’s National Medical Center, USA
1 protocol

Yulong Fu Center for Cancer and Immunology Research, Children’s National Medical Center, USA
1 protocol

Reviewer
Junyi Zhu
  • Post-Doc, University of California, Los Angeles
Research focus
  • Developmental biology
  • 1 Author merit

Education

PhD, University of Tübingen, 2010

Publications

1. Wang, Y., Liu, Y.Z., Tang, W., Zhu, J.Y., Chen, Q., Wang, Z., NMDA receptor-gated visual responses in hippocampal CA1 neurons. Journal of Physiology (Epub ahead of print).

2. Basu, M., Zhu, J.Y., LaHaye S., Majumdar U., Jiao K., Han, Z., Grag, V. (2017) Epigenetic mechanism underlying maternal diabetes-associated risk of congenital heart disease. JCI Insight 2(20).

3. Zhu, J.Y.*, Fu, Y.*, Richman, A., Han, Z. (2017) Validating Candidate Congenital Heart Disease Genes in Drosophila. Bio-Protocol 7(12). (*equal contribution)

4. Zhu, J.Y.*, Fu, Y.*, Richman, A., Zhao, Z., Ray, P.E., Han, Z. (2017) A personalized Drosophila model of COQ2 nephropathy rescued by the wild-type human COQ2 allele and dietary Q10 supplementation. Journal of the American Society of Nephrology 28(9): 2607-2617. (*equal contribution)
- Featured on the cover of the September 2017 issue of JASN.

5. Zhu, J.Y.*, Fu, Y.*, Nettleton, M., Richman, A., Han, Z. (2017) High throughput in vivo functional validation of candidate congenital heart disease genes in Drosophila. eLife 6, e22617. (*equal contribution)

6. Zhu, J.Y., Heidersbach, A., Kathiriya, I.S., Garay, B., Carver-Moore, K., Ivey, K.N., Srivastava, D., Han, Z., King, I.N. (2017) The E3 Ubiquitin Ligase Nedd4/Nedd4L is Directly Regulated by microRNA-1. Development 144(5):866-875.

7. Fu, Y. *, Zhu, J.Y*, Richman A., Zhang, Y., Xie, X., Das, J.R., Li, J., Ray, P.E., Han, Z. (2017) APOL1-G1 in Drosophila nephrocytes induces hypertrophy and accelerates cell death. Journal of the American Society of Nephrology 28(4):1106-1116. (*equal contribution)
- It is featured in the Research Highlight of Nature Review Nephrology in an editorial titled “Mechanisms of APOL1-associated renal disease”.

8. Fu, Y.*, Zhu, J.Y.*, Richman, A., Zhao, Z., Zhang, F., Ray, P.E., Han, Z., (2017) A Drosophila model system to assess the function of human monogenic podocyte mutations that cause nephrotic syndrome. Human Molecular Genetics 26(4):768-780. (*equal contribution)

9. Fu, Y.*, Zhu, J.Y.*, Zhang, F.*, Richman, A, Zhao, Z., Han, Z., (2017) Comprehensive functional analysis of Rab GTPases in Drosophila. Cell & Tissue Research 368(3):615-627. (*equal contribution)

10. Patel M.V., Zhu, J.Y., Jiang, Z., Richman, A., Van Berkum M.F., Han, Z. (2016) Gia/Mthl5 is an aorta specific GPCR required for Drosophila heart tube morphology and normal pericardial cell positioning. Developmental Biology 414(1), 100-107.

11. Chen, Z., Zhu, J.Y., Fu, Y., Richman, A., Han, Z. (2016) Wnt4 is required for ostia development in the Drosophila heart. Developmental Biology 413(2), 188-198.

12. Gee, H.Y., Zhang F., Ashraf, S., Kohl, S., Sadowski C., Vega-Warner, V., Zhou, W., Lovric, S., Fang H., Nettleton, M., Zhu, J.Y., Hoefele, J., Weber, L., Podracka, L., Boor, A., Fehrebach, H., Innis, J., Washburn, J., Levy, S., Lifton, R.P., Otto, E., Han, Z., Hildebrandt, F. (2015) KANK deficiency leads to defective podocyte function and nephrotic syndrome. Journal of Clinical Investigation 125, 2375-2384.

13. Zhu, J.Y., Vereshchagina, N., Sreekumar, V., Burbulla, L.F., Costa, A.C., Daub, K.J., Woitalla D., Miguel Martins, L., Krüger, R.#, Rasse T.M.#, (2013) Knockdown of Hsc70-5/Mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson’s disease model. PLoS ONE 8(12): e83714. (#co-corresponding author)

14. Li, D., Zhu, J.Y., Zhou, Y.Y., Liu, X.M., (2009) Influence of DNAzymes against Cycl in D1 in Tumor Cell Cycle (Article in Chinese). Journal of Biomedical Engineering 2009 Apr; 26(2):374-8, 384.

15. Li, X.W., Zhou, Y.Y., Zhu, J.Y., Li, D., (2008) Regulation of hTERT on the expression of cell cycle gene in Hela cell line in vitro (Article in Chinese). Journal of Public Health and Preventive Medicine 2008; 19(6): 4-7, 384.

1 Protocol published
Validating Candidate Congenital Heart Disease Genes in Drosophila
Authors:  Jun-yi Zhu, Yulong Fu, Adam Richman and Zhe Han, date: 06/20/2017, view: 2394, Q&A: 0
Genomic sequencing efforts can implicate large numbers of genes and de novo mutations as potential disease risk factors. A high throughput in vivo model system to validate candidate gene association with pathology is therefore ...