Maria D’Império-Lima Instituto de Ciências Biomédicas, Universidade de São Paulo, Brazil
3 protocols

Carlos Tadokoro Universidade de Vila Velha, Brazil
2 protocols
Guadalupe Ortiz-Muñoz University of California
1 protocol

Ivan Zanoni Harvard Medical School
78 protocols

Rakesh Chatrikhi University of Pennsylvania
3 protocols

Henrique Borges da Borges da Silva
  • University of Minnesota
Research focus
  • Immunology
  • 2 Author merit


Ph.D. in Immunology, University of Sao Paulo, Sao Paulo, Brazil, 2014

Current position

Postdoctoral Associate, Department of Lab Medicine and Pathology, University of Minnesota


  1. Borges da Silva, H., Fonseca, R., Cassado Ados, A., Machado de Salles, E., de Menezes, M. N., Langhorne, J., Perez, K. R., Cuccovia, I. M., Ryffel, B., Barreto, V. M., Marinho, C. R., Boscardin, S. B., Alvarez, J. M., D'Imperio-Lima, M. R. and Tadokoro, C. E. (2015). In vivo approaches reveal a key role for DCs in CD4+ T cell activation and parasite clearance during the acute phase of experimental blood-stage malaria. PLoS Pathog 11(2): e1004598.

  2. Borges da Silva, H., Fonseca, R., Alvarez, J. M. and D'Imperio Lima, M. R. (2015). IFN-gamma Priming Effects on the Maintenance of Effector Memory CD4(+) T Cells and on Phagocyte Function: Evidences from Infectious Diseases. J Immunol Res 2015: 202816.

  3. Borges da Silva, H., Fonseca, R., Pereira, R. M., Cassado Ados, A., Alvarez, J. M. and D'Imperio Lima, M. R. (2015). Splenic Macrophage Subsets and Their Function during Blood-Borne Infections. Front Immunol 6: 480.

  4. Alvarez, J. M., Fonseca, R., Borges da Silva, H., Marinho, C. R., Bortoluci, K. R., Sardinha, L. R., Epiphanio, S. and D'Imperio Lima, M. R. (2014). Chagas disease: still many unsolved issues. Mediators Inflamm 2014: 912965.

  5. Koyama, F. C., Carvalho, T. L., Alves, E., da Silva, H. B., de Azevedo, M. F., Hemerly, A. S. and Garcia, C. R. (2013). The structurally related auxin and melatonin tryptophan-derivatives and their roles in Arabidopsis thaliana and in the human malaria parasite Plasmodium falciparum. J Eukaryot Microbiol 60(6): 646-651.

  6. Medeiros, M. M., da Silva, H. B., Reis, A. S., Barboza, R., Thompson, J., Lima, M. R., Marinho, C. R. and Tadokoro, C. E. (2013). Liver accumulation of Plasmodium chabaudi-infected red blood cells and modulation of regulatory T cell and dendritic cell responses. PLoS One 8(11): e81409.

  7. da Silva, H. B., de Salles, E. M., Panatieri, R. H., Boscardin, S. B., Rodriguez-Malaga, S. M., Alvarez, J. M. and D'Imperio Lima, M. R. (2013). IFN-gamma-induced priming maintains long-term strain-transcending immunity against blood-stage Plasmodium chabaudi malaria. J Immunol 191(10): 5160-5169.

  8. Moreira, V., Teixeira, C., Borges da Silva, H., D'Imperio Lima, M. R. and Dos-Santos, M. C. (2013). The crucial role of the MyD88 adaptor protein in the inflammatory response induced by Bothrops atrox venom. Toxicon 67: 37-46.

  9. da Silva, H. B., Amaral, E. P., Nolasco, E. L., de Victo, N. C., Atique, R., Jank, C. C., Anschau, V., Zerbini, L. F. and Correa, R. G. (2013). Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer. Prostate Cancer 2013: 920612.

  10. da Silva, H. B., Caetano, S. S., Monteiro, I., Gomez-Conde, I., Hanson, K., Penha-Goncalves, C., Olivieri, D. N., Mota, M. M., Marinho, C. R., D'Imperio Lima, M. R. and Tadokoro, C. E. (2012). Early skin immunological disturbance after Plasmodium-infected mosquito bites. Cell Immunol 277(1-2): 22-32.

  11. Moreira, V., Dos-Santos, M. C., Nascimento, N. G., Borges da Silva, H., Fernandes, C. M., D'Imperio Lima, M. R. and Teixeira, C. (2012). Local inflammatory events induced by Bothrops atrox snake venom and the release of distinct classes of inflammatory mediators. Toxicon 60(1): 12-20.

  12. Bagnaresi, P., Alves, E., da Silva, H. B., Epiphanio, S., Mota, M. M. and Garcia, C. R. (2009). Unlike the synchronous Plasmodium falciparum and P. chabaudi infection, the P. berghei and P. yoelii asynchronous infections are not affected by melatonin. Int J Gen Med 2: 47-55.

2 Protocols published
To evaluate precisely the relative roles of different splenic phagocytic cells during an immune response, efficient methods for the depletion of specific populations are needed. Here, we describe the protocols for the depletion of splenic dendritic ...
Efficient staining methods to identify Plasmodium-infected red blood cells (iRBCs) are crucial to discriminate precisely the immune cells responsible for their elimination from circulation. Here, we describe the protocol for the ...
2 Protocols reviewed
A Rigorous Quantitative Approach to Analyzing Phagocytosis Assays
Authors:  Michael D. Caponegro, Kaitlyn Koenig Thompson, Maryam Tayyab and Stella E. Tsirka, date: 01/05/2021, view: 2263, Q&A: 0
Studying monocytic cells in isolated systems in vitro contributes significantly to the understanding of innate immune physiology. Functional assays produce read outs which can be used to measure responses to selected stimuli, such as ...
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Detection of Intracellular Reduced (Catalytically Active) SHP-1 and Analyses of Catalytically Inactive SHP-1 after Oxidation by Pervanadate or H2O2
Authors:  Seeyoung Choi and Paul E. Love, date: 01/05/2018, view: 4693, Q&A: 0
Oxidative inactivation of cysteine-dependent Protein Tyrosine Phosphatases (PTPs) by cellular reactive oxygen species (ROS) plays a critical role in regulating signal transduction in multiple cell types. The phosphatase activity of most PTPs depends ...
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