Josep Baulida Programa de Recerca en Cáncer, Institut Hospital del mar d’Investigacions Mèdiques, Spain
1 protocol

Félix Bonilla Centro de Estudios Biosanitarios, Spain
1 protocol

Antonio Herreros Programa de Recerca en Cáncer, Institut Hospital del mar d’Investigacions Mèdiques, Spain
1 protocol

Gemma Ferrer-Mayorga Instituto de Investigaciones Biomédicas “Alberto Sols”, Consejo Superio de Investigaciones Científicas, Universidad Autónoma de Madrid, Spain
1 protocol

Cristina Peña
  • Hospital Universitario Ramón y Cajal
Research focus
  • Cancer biology
  • 1 Author merit


Ph.D. in Medicine, Universidad Autónoma de Madrid, 2005

Current position

Ph.D. senior position, "Cancer Cell Signalling" Research Group, Hospital Universitario Puerta de Hierro. Majadahonda. Madrid, SPAIN
Ph.D. senior position, Hospital Universitario Ramón y Cajal, Madrid, SPAIN

Publications (since 2010)

  1. Rodriguez, M., Silva, J., Herrera, A., Herrera, M., Pena, C., Martin, P., Gil-Calderon, B., Larriba, M. J., Coronado, M. J., Soldevilla, B., Turrion, V. S., Provencio, M., Sanchez, A., Bonilla, F. and Garcia-Barberan, V. (2015). Exosomes enriched in stemness/metastatic-related mRNAS promote oncogenic potential in breast cancer. Oncotarget 6(38): 40575-40587.
  2. Torres, S., Garcia-Palmero, I., Herrera, M., Bartolome, R. A., Pena, C., Fernandez-Acenero, M. J., Padilla, G., Pelaez-Garcia, A., Lopez-Lucendo, M., Rodriguez-Merlo, R., Garcia de Herreros, A., Bonilla, F. and Casal, J. I. (2015). LOXL2 Is Highly Expressed in Cancer-Associated Fibroblasts and Associates to Poor Colon Cancer Survival. Clin Cancer Res 21(21): 4892-4902.
  3. San Millan, C., Soldevilla, B., Martin, P., Gil-Calderon, B., Compte, M., Perez-Sacristan, B., Donoso, E., Pena, C., Romero, J., Granado-Lorencio, F., Bonilla, F. and Dominguez, G. (2015). beta-Cryptoxanthin Synergistically Enhances the Antitumoral Activity of Oxaliplatin through DeltaNP73 Negative Regulation in Colon Cancer. Clin Cancer Res 21(19): 4398-4409.
  4. Stanisavljevic, J., Loubat-Casanovas, J., Herrera, M., Luque, T., Pena, R., Lluch, A., Albanell, J., Bonilla, F., Rovira, A., Pena, C., Navajas, D., Rojo, F., Garcia de Herreros, A. and Baulida, J. (2015). Snail1-expressing fibroblasts in the tumor microenvironment display mechanical properties that support metastasis. Cancer Res 75(2): 284-295.
  5. Rodriguez, M., Silva, J., Lopez-Alfonso, A., Lopez-Muniz, M. B., Pena, C., Dominguez, G., Garcia, J. M., Lopez-Gonzalez, A., Mendez, M., Provencio, M., Garcia, V. and Bonilla, F. (2014). Different exosome cargo from plasma/bronchoalveolar lavage in non-small-cell lung cancer. Genes Chromosomes Cancer 53(9): 713-724.
  6. Herrera, A., Herrera, M., Alba-Castellon, L., Silva, J., Garcia, V., Loubat-Casanovas, J., Alvarez-Cienfuegos, A., Miguel Garcia, J., Rodriguez, R., Gil, B., Ma Jesus, C., Ma Jesus, L., Ignacio Casal, J., de Herreros, A. G., Bonilla, F. and Pena, C. (2014). Protumorigenic effects of Snail-expression fibroblasts on colon cancer cells. Int J Cancer 134(12): 2984-2990.
  7. Torres, S., Bartolome, R. A., Mendes, M., Barderas, R., Fernandez-Acenero, M. J., Pelaez-Garcia, A., Pena, C., Lopez-Lucendo, M., Villar-Vazquez, R., de Herreros, A. G., Bonilla, F. and Casal, J. I. (2013). Proteome profiling of cancer-associated fibroblasts identifies novel proinflammatory signatures and prognostic markers for colorectal cancer. Clin Cancer Res 19(21): 6006-6019.
  8. Herrera, M., Islam, A. B., Herrera, A., Martin, P., Garcia, V., Silva, J., Garcia, J. M., Salas, C., Casal, I., de Herreros, A. G., Bonilla, F. and Pena, C. (2013). Functional heterogeneity of cancer-associated fibroblasts from human colon tumors shows specific prognostic gene expression signature. Clin Cancer Res 19(21): 5914-5926.
  9. Frings, O., Augsten, M., Tobin, N. P., Carlson, J., Paulsson, J., Pena, C., Olsson, E., Veerla, S., Bergh, J., Ostman, A. and Sonnhammer, E. L. (2013). Prognostic significance in breast cancer of a gene signature capturing stromal PDGF signaling. Am J Pathol 182(6): 2037-2047.
  10. Pena, C., Cespedes, M. V., Lindh, M. B., Kiflemariam, S., Mezheyeuski, A., Edqvist, P. H., Hagglof, C., Birgisson, H., Bojmar, L., Jirstrom, K., Sandstrom, P., Olsson, E., Veerla, S., Gallardo, A., Sjoblom, T., Chang, A. C., Reddel, R. R., Mangues, R., Augsten, M. and Ostman, A. (2013). STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer. Cancer Res 73(4): 1287-1297.
  11. Herrera, M., Herrera, A., Dominguez, G., Silva, J., Garcia, V., Garcia, J. M., Gomez, I., Soldevilla, B., Munoz, C., Provencio, M., Campos-Martin, Y., Garcia de Herreros, A., Casal, I., Bonilla, F. and Pena, C. (2013). Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients. Cancer Sci 104(4): 437-444.
  12. Silva, J., Garcia, V., Rodriguez, M., Compte, M., Cisneros, E., Veguillas, P., Garcia, J. M., Dominguez, G., Campos-Martin, Y., Cuevas, J., Pena, C., Herrera, M., Diaz, R., Mohammed, N. and Bonilla, F. (2012). Analysis of exosome release and its prognostic value in human colorectal cancer. Genes Chromosomes Cancer 51(4): 409-418.
  13. Soldevilla, B., Diaz, R., Silva, J., Campos-Martin, Y., Munoz, C., Garcia, V., Garcia, J. M., Pena, C., Herrera, M., Rodriguez, M., Gomez, I., Mohamed, N., Marques, M. M., Bonilla, F. and Dominguez, G. (2011). Prognostic impact of DeltaTAp73 isoform levels and their target genes in colon cancer patients. Clin Cancer Res 17(18): 6029-6039.
  14. Mohammed, N., Rodriguez, M., Garcia, V., Garcia, J. M., Dominguez, G., Pena, C., Herrera, M., Gomez, I., Diaz, R., Soldevilla, B., Herrera, A., Silva, J. and Bonilla, F. (2011). EPAS1 mRNA in plasma from colorectal cancer patients is associated with poor outcome in advanced stages. Oncol Lett 2(4): 719-724.
  15. Gomez, I., Pena, C., Herrera, M., Munoz, C., Larriba, M. J., Garcia, V., Dominguez, G., Silva, J., Rodriguez, R., Garcia de Herreros, A., Bonilla, F. and Garcia, J. M. (2011). TWIST1 is expressed in colorectal carcinomas and predicts patient survival. PLoS One 6(3): e18023.
  16. Silva, J., Garcia, V., Zaballos, A., Provencio, M., Lombardia, L., Almonacid, L., Garcia, J. M., Dominguez, G., Pena, C., Diaz, R., Herrera, M., Varela, A. and Bonilla, F. (2011). Vesicle-related microRNAs in plasma of nonsmall cell lung cancer patients and correlation with survival. Eur Respir J 37(3): 617-623.
  17. Diaz, R., Gonzalez-Sancho, J. M., Soldevilla, B., Silva, J., Garcia, J. M., Garcia, V., Pena, C., Herrera, M., Gomez, I., Bonilla, F. and Dominguez, G. (2010). Differential regulation of TP73 isoforms by 1alpha,25-dihydroxyvitamin D3 and survivin in human colon and breast carcinomas. Genes Chromosomes Cancer 49(12): 1135-1142.
  18. Hagerstrand, D., Lindh, M. B., Pena, C., Garcia-Echeverria, C., Nister, M., Hofmann, F. and Ostman, A. (2010). PI3K/PTEN/Akt pathway status affects the sensitivity of high-grade glioma cell cultures to the insulin-like growth factor-1 receptor inhibitor NVP-AEW541. Neuro Oncol 12(9): 967-975.
  19. Saito, R. A., Micke, P., Paulsson, J., Augsten, M., Pena, C., Jonsson, P., Botling, J., Edlund, K., Johansson, L., Carlsson, P., Jirstrom, K., Miyazono, K. and Ostman, A. (2010). Forkhead box F1 regulates tumor-promoting properties of cancer-associated fibroblasts in lung cancer. Cancer Res 70(7): 2644-2654.
  20. Augsten, M., Hagglof, C., Pena, C. and Ostman, A. (2010). A digest on the role of the tumor microenvironment in gastrointestinal cancers. Cancer Microenviron 3(1): 167-176.
1 Protocol published
Colon Cancer-associated Fibroblast Establishment and Culture Growth
Cancer-associated fibroblasts (CAFs) are one of the major players in tumor-stroma crosstalk. Findings in experimental studies suggest important roles for CAFs in regulation of tumor growth, metastasis and drug response (Hanahan and Coussens, 2012). ...
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