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Anca Savulescu University of Cape Town
13 protocols

Andrea Puhar MIMS - Umeå University
39 protocols

Carsten Ade University of Würzburg
4 protocols

G. Bhanuprakash Reddy National Institute of Nutrition
1 protocol

Reviewer
Yong Teng
  • Assistant Professor, Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia , Department of Biochemistry & Molecular Biology, Medical College of Georgia, Department of Medical Laboratory, Imaging and Radiologic Sciences, College of Allied Health Sciences, Georgia Cancer Center, Augusta University, Augusta, USA
Research focus
  • Cancer biology
  • Cancer biology; Animal disease models, Drug discovery
  • 1 Author merit

Education

Ph.D., Sun Yat-sen University

Publications

1. Gao L, Zhao X, Lang L, Shay C, Andrew Yeudall W, Teng Y*. (2018). Blockade of autophagy augments anticancer activity of CYT997 in human head and neck squamous carcinoma. J Mol Med, 96(9), 929-938.
2. Lang L, Shay C, Xiong Y, Thakkar P, Chemmalakuzhy R, Wang X, Teng Y*. (2018). Combating Head and Neck Cancer Metastases by Targeting Src Using Multifunctional Nanoparticle-based Saracatinib. J Hematol Oncol., 11(1):85.
3. Teng Y*, Zhao H, Gao L, Zhang W, Shull A, Shay C. (2017). FGF19 protects hepatocellular carcinoma cells against endoplasmic reticulum stress via activation of FGFR4-GSK3β-Nrf2 signaling. Cancer Res., 77(22):6215-6225.
4. Lang L, Shay C, Zhao X, Teng Y*. (2017). Combined targeting of Arf1 and Ras potentiates anticancer activity for prostate cancer therapeutics. J Exp Clin Cancer Res., 36:112.
5. Teng Y*, Cai Y, Pi W, Gao L, Shay C. (2017). Augmentation of the anticancer activity of CYT997 in human prostate cancer by inhibiting Src activity. J Hematol Oncol., 10(1):118.
6. Gao L, Wang X, Tang Y, Huang S, Hu CA, Teng Y*. (2017). FGF19 signaling contributes to resistance of hepatocellular carcinoma to sorafenib. J Exp Clin Cancer Res., 36(1):8.
7. Fang D, Chen H, Zhu JY, Wang W, Teng Y, Ding HF, Jing Q, Su S, Huang S. (2017). Epithelial-mesenchymal transition of ovarian cancer cells is sustained by Rac1 through simultaneous activation of MEK1/2 and Src signaling pathways. Oncogene, 36(11):1546-1558.
8. Xie X, Tang S, Cai Y, Pi W, Deng L, Wu G, Chavanieu A, Teng Y*. (2016). Suppression of breast cancer metastasis by the inactivation of ADP-ribosylation factor 1. Oncotarget, 7(36):58111-58120.
9. Teng Y*, Qin H, Bahassan A, Bendzunas NG, Kennedy EJ, Cowell JK. (2018). The WASF3-CYFIP-NCKAP1 complex is essential for breast cancer metastasis. Cancer Res 2016, 76(17):5133-42.
10. Teng Y*, Ren X, Li H, Shull A, Kim J, Cowell JK. (2016). Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein. Oncogene, 35(3):333-43.
11. Teng Y*, Abdulaziz B, Dong D, Hanold LE, Ren X, Kennedy EJ, Cowell J. (2018). Targeting the WASF3-CYFIP1 complex using stapled peptides leads to loss of invasion in cancer cells. Cancer Res. 2016,76:965-973.
12. Teng Y*, Pi W, Wang Y, Cowell JK. (2016). WASF3 provides the conduit to facilitate invasion and metastasis in breast cancer cells through HER2/HER3 signaling. Oncogene, 35(35):4633-40.
13. Zhao H, Lv F, Liang G, Huang X, Wu G, Zhang W, Yu L, Shi L, Teng Y*. (2016). FGF19 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells by modulating the GSK3β/β-catenin signaling cascade via FGFR4 activation. Oncotarget, 7(12):13575-86.
14. Wang Z, Kim J, Teng Y, Ding HF, Zhang JR, Hai T, Cowell JK, Yan CH. (2016). Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5+CK8+ epithelial cells. Oncogene, 35(27):3555-64.
15. Teng Y*, Mei Y, Hawthorn L, Cowell JK. (2014). WASF3 regulates the inactivation of miR-200 by ZEB1 through suppression of KISS1 leading to increased invasiveness in breast cancer cells. Oncogene, 33(2):203-11.
16. Teng Y*, Xie X, Walker S, Mumm JS, Cowell JK. (2013). Zebrafish as a model for evaluating metastatic potential of human cancer cells. BMC Cancer, 13(1):453.
17. Teng Y*, Ghoshal P, Ngoka L, Mei Y, Cowell JK. (2013). Critical role of the WASF3 gene in JAK2/STAT3 regulation of cancer cell invasion. Carcinogenesis, 34(9):1994-9.
18. Xie X, Smith M, Mathias JR, Walker SL, Teng Y, Distel M, Köster RM, Sirotkin HI, Saxena MT, Mumm JS. (2012). Silencer-delimited transgenesis: NRSE/RE1 sequences promote NRSF/REST-dependent neural-specific transgene expression. BMC Biology, 10:93.
19. Teng Y, Ngoka L, Mei Y, Lesoon L, Cowell JK. (2012). HSP90 and HSP70 are essential for stabilization and activation of the WASF3 metastasis promoting protein. J. Biol. Chem., 287(13):10051-9.
20. Teng Y, Liu MY, Cowell JK. (2011). Functional interrelationship between the WASF3 and KISS1 metastasis associated genes in breast cancer cells. Int. J. Cancer, 129(12):2825-35.
21. Teng Y, Xie X, Walker S, Rempala G, Kozlowski DJ, Mumm JS, Cowell JK. (2010). Knockdown of zebrafish Lgi1a results in abnormal development, brain defects and a seizure-like behavioral Phenotype. Hum. Mol. Genet, 19(22):4409-20.
22. Teng Y, Ren MQ, Cheney R, Sharma S, Cowell JK. (2010). Inactivation of the WASF3 gene in prostate cancer cells leads to suppression of tumorigenicity and metastases. Br. J. Cancer, 103(7):1066-75.
1 Protocol published
Hanging Drop Aggregation Assay of Breast Cancer Cells
Author:  Yong Teng, date: 02/05/2015, view: 9927, Q&A: 0
Hanging drop assay can be used to investigate cell-cell cohesion and cell-substratum adhesion through generation of 3D spheroids under physiological conditions. It also can be used to elucidate the role of cell-cell or cell-ECM interactions in ...
8 Protocols reviewed
Zebrafish Embryo Xenograft and Metastasis Assay
Authors:  Ilkka Paatero, Sanni Alve, Silvia Gramolelli, Johanna Ivaska and Päivi M. Ojala, date: 09/20/2018, view: 521, Q&A: 0
Xenograft models, and in particular the mouse xenograft model, where human cancer cells are transplanted into immunocompromised mice, have been used extensively in cancer studies. Although these models have contributed enormously to our ...
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Measuring CD38 Hydrolase and Cyclase Activities: 1,N6-Ethenonicotinamide Adenine Dinucleotide (ε-NAD) and Nicotinamide Guanine Dinucleotide (NGD) Fluorescence-based Methods
CD38 is a multifunctional enzyme involved in calcium signaling and Nicotinamide Adenine Dinucleotide (NAD+) metabolism. Through its major activity, the hydrolysis of NAD+, CD38 helps maintain the appropriate levels of this ...
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