Aleksei Lulla Institute of Technology, University of Tartu, Estonia
1 protocol

Andres Merits Institute of Technology, University of Tartu, Estonia
1 protocol

Valeria Lulla
  • University of Cambridge
Research focus
  • Microbiology
  • 1 Author merit


Ph.D. in Virology, Institute of Molecular and Cell Biology, University of Tartu, Estonia, 2007

Current position

Research scientist at the Institute of Technology, University of Tartu, Estonia

Publications (since 2005)

  1. Hallengard, D., Kakoulidou, M., Lulla, A., Kummerer, B. M., Johansson, D. X., Mutso, M., Lulla, V., Fazakerley, J. K., Roques, P., Le Grand, R., Merits, A. and Liljestrom, P. (2014). Novel attenuated Chikungunya vaccine candidates elicit protective immunity in C57BL/6 mice. J Virol 88(5): 2858-2866.
  2. Lulla, V., Kim, D. Y., Frolova, E. I. and Frolov, I. (2013). The amino-terminal domain of alphavirus capsid protein is dispensable for viral particle assembly but regulates RNA encapsidation through cooperative functions of its subdomains. J Virol 87(22): 12003-12019.
  3. Nikonov, A., Molder, T., Sikut, R., Kiiver, K., Mannik, A., Toots, U., Lulla, A., Lulla, V., Utt, A., Merits, A. and Ustav, M. (2013). RIG-I and MDA-5 detection of viral RNA-dependent RNA polymerase activity restricts positive-strand RNA virus replication. PLoS Pathog 9(9): e1003610.
  4. Lulla, V., Karo-Astover, L., Rausalu, K., Merits, A. and Lulla, A. (2013). Presentation overrides specificity: probing the plasticity of alphaviral proteolytic activity through mutational analysis. J Virol 87(18): 10207-10220.
  5. Glasker, S., Lulla, A., Lulla, V., Couderc, T., Drexler, J. F., Liljestrom, P., Lecuit, M., Drosten, C., Merits, A. and Kummerer, B. M. (2013). Virus replicon particle based Chikungunya virus neutralization assay using Gaussia luciferase as readout. Virol J 10: 235.
  6. Teo, T. H., Lum, F. M., Claser, C., Lulla, V., Lulla, A., Merits, A., Renia, L. and Ng, L. F. (2013). A pathogenic role for CD4+ T cells during Chikungunya virus infection in mice. J Immunol 190(1): 259-269.
  7. Lulla, A., Lulla, V. and Merits, A. (2012). Macromolecular assembly-driven processing of the 2/3 cleavage site in the alphavirus replicase polyprotein. J Virol 86(1): 553-565.
  8. Rausalu, K., Iofik, A., Ulper, L., Karo-Astover, L., Lulla, V. and Merits, A. (2009). Properties and use of novel replication-competent vectors based on Semliki Forest virus. Virol J 6: 33.
  9. Lulla, V., Sawicki, D. L., Sawicki, S. G., Lulla, A., Merits, A. and Ahola, T. (2008). Molecular defects caused by temperature-sensitive mutations in Semliki Forest virus nsP1. J Virol 82(18): 9236-9244.
  10. Tamberg, N., Lulla, V., Fragkoudis, R., Lulla, A., Fazakerley, J. K. and Merits, A. (2007). Insertion of EGFP into the replicase gene of Semliki Forest virus results in a novel, genetically stable marker virus. J Gen Virol 88(Pt 4): 1225-1230.
  11. Lulla, V., Merits, A., Sarin, P., Kaariainen, L., Keranen, S. and Ahola, T. (2006). Identification of mutations causing temperature-sensitive defects in Semliki Forest virus RNA synthesis. J Virol 80(6): 3108-3111.
  12. Lulla, A., Lulla, V., Tints, K., Ahola, T. and Merits, A. (2006). Molecular determinants of substrate specificity for Semliki Forest virus nonstructural protease. J Virol 80(11): 5413-5422.
1 Protocol published
IFN-α/β Detection Assay Using Sensor Cell Lines
Authors:  Valeria Lulla, Andres Merits and Aleksei Lulla, date: 05/20/2014, view: 4179, Q&A: 0
Type I interferons (IFN-α/β) play an important role in host resistance to viral infections. Signaling through the JAK-STAT pathway, IFN-α/β stimulates response elements (ISRE) in the promoters of ISG to regulate their expression (reviewed in ...