Andres Merits Institute of Technology, University of Tartu
2 protocols

Andrew Firth Department of pathology, University of Cambridge, UK, UK,
1 protocol

Aleksei Lulla Institute of Technology, University of Tartu, Estonia
1 protocol
David Paul MRC Laboratory of Molecular Biology
41 protocols

Kristopher Marjon Stanford Univeristy
5 protocols

Timo Lehti University of Helsinki
18 protocols

Vaibhav Shah The University of New South Wales
19 protocols

Valeria Lulla
  • Post-Doc, Department of pathology, University of Cambridge, UK
Research focus
  • Microbiology
  • RNA viruses
  • 2 Author merit


PhD, 2007

Lab information

Andrew Firth lab


1. Lulla V, Dinan AM, Hosmillo M, Chaudhry Y, Sherry L, Irigoyen N, Nayak KM, Stonehouse NJ, Zilbauer M, Goodfellow I, Firth AE. (2019). An upstream protein-coding region in enteroviruses modulates virus infection in gut epithelial cells. Nature Microbiology, 4(2):280-292.
2. Mutso M, Morro AM, Smedberg C, Kasvandik S, Aquilimeba M, Teppor M, Tarve L, Lulla A, Lulla V, Saul S, McInerney GM, Merits A, Varjak M. (2018). Mutation of CD2AP and SH3KBP1 binding motif in alphavirus nsP3 hypervariable domain results in attenuated virus. Viruses, 10(5).
3. Lulla V, Karo-Astover L, Rausalu K, Saul S, Merits A, Lulla A. (2018). Timeliness of proteolytic events is prerequisite for efficient functioning of the alphaviral replicase. Journal of Virology, 92(14).
4. Lulla V, Losada A, Lecollinet S, Kerviel A, Lilin T, Sailleau C, Beck C, Zientara S, Roy P. (2017). Protective efficacy of multivalent replication-abortive vaccine strains in horses against African horse sickness virus challenge. Vaccine, 35(33):4262-4269.
5. Lulla V, Lulla A, Wernike K, Aebischer A, Beer M, Roy P. (2016). Assembly of replication-Incompetent African horse sickness virus particles: rational design of vaccines for all serotypes. Journal of Virology, 90(16):7405-14.
6. Ramachandran M, Yu D, Dyczynski M, Baskaran S, Zhang L, Lulla A, Lulla V, Saul S, Nelander S, Dimberg A, Merits A, Leja-Jarblad J, Essand M. (2016). Safe and effective treatment of experimental neuroblastoma and glioblastoma using systemically delivered triple microRNA-detargeted oncolytic Semliki Forest virus. Clinical Cancer Research, 23(6):1519-1530.
7. Reynaud JM, Lulla V, Kim DY, Frolova EI, Frolov I. (2015). The SD1 subdomain of Venezuelan equine encephalitis virus capsid protein plays a critical role in nucleocapsid and particle assembly. Journal of Virology, 90(4):2008-2020.
8. Utt A, Das PK, Varjak M, Lulla V, Lulla A, Merits A. (2015). Mutations conferring a noncytotoxic phenotype on Chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2. Journal of Virology, 89: 3145-3162.
9. Her Z, Teng TS, Tan JJL, Teo TH, Kam YW, Lum FM, Lee WWL, Gabriel C, Melchiotti R, Andiappan AK, Lulla V, Lulla A, Win MK, Chow A, Biswas SK, Leo YS, Lecuit M, Merits A, Rénia L, Ng LF. (2015). Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus‐specific neutralizing antibody response. EMBO Molecular Medicine 7: 24-41.
10. Hallengärd D, Lum FM, Kümmerer B, Lulla A, Lulla V, Garcia-Arriaza J, Fazakerley JK, Roques P, Le Grand R, Merits A, Ng LF, Esteban M, Liljeström P. (2014). Prime-boost immunization strategies against Chikungunya virus. Journal of Virology, 88: 13333-13343.
11. Hallengärd D, Kakoulidou M, Lulla A, Kümmerer B, Johansson D, Mutso M, Lulla V, Fazakerley F, Roques P, Le Grand R, Merits A, Liljeström P. (2014). Novel attenuated Chikungunya vaccine candidates elicit protective immunity in C57BL/6 mice. Journal of Virology, 88: 2858-2866.
12. Lulla V, Kim DY, Frolova EI, Frolov I. (2013). The amino-terminal domain of alphavirus capsid protein is dispensable for viral particle assembly, but regulates RNA encapsidation through cooperative function of its subdomains. Journal of Virology, 87: 12003-12019.
13. Nikonov A, Mölder T, Sikut R, Kiiver K, Männik A, Toots U, Lulla A, Lulla V, Utt A, Merits A, Ustav M. (2013). RIG-I and MDA-5 detection of viral RNA-dependent RNA polymerase activity restricts positive-strand RNA virus replication. PLoS Pathogens, 9: e1003610.
14. Lulla V, Karo-Astover L, Rausalu K, Merits A, Lulla A. (2013). Presentation overrides specificity: probing the plasticity of alphaviral proteolytic activity through mutational analysis. Journal of Virology, 87: 10207-10220.
15. Gläsker S, Lulla A, Lulla V, Couderc T, Liljeström P, Lecuit M, Drosten C, Merits A, Kuemmerer BM. (2013). Virus replicon particle based Chikungunya virus neutralization assay using Gaussia luciferase as readout. Virology Journal, 10: 235.
16. Teo T-H, Lum F-M, Claser C, Lulla V, Lulla A, Merits A, Renia L, Ng LFP. (2013). A pathogenic role for CD4+ T cells during Chikungunya virus infection in mice. Journal of Immunology, 190: 259-269.
17. Lulla A, Lulla V, Merits A. (2012). Macromolecular assembly-driven processing of the 2/3 cleavage site in the alphavirus replicase polyprotein. Journal of Virology, 86: 553-565.
18. Rausalu K, Iofik A, Ülper L, Karo-Astover L, Lulla V, Merits A. (2009). Properties and use of novel replication-competent vectors based on Semliki Forest virus. Virology Journal, 6: 33.
19. Lulla V, Sawicki DL, Sawicki SG, Lulla A, Merits A, Ahola T. (2008). Molecular defects caused by temperature-sensitive mutations in Semliki Forest virus nsP1. Journal of Virology, 82: 9236-9244.
20. Tamberg N, Lulla V, Fragkoudis R, Lulla A, Fazakerley J, Merits A. (2007). Insertion of EGFP into the replicase gene of Semliki Forest virus results in novel, genetically stable marker virus. Journal of General Virology, 88: 1225-1230.
21. Lulla V, Merits A, Sarin P, Kääriäinen L, Keränen S, Ahola T. (2006). Identification of mutations causing temperature-sensitive defects in Semliki Forest virus RNA synthesis. Journal of Virology, 80: 3108-3111.
22. Lulla A, Lulla V, Tints K, Ahola T, Merits A. (2006). Molecular determinants of substrate specificity for Semliki Forest virus nonstructural protease. Journal of Virology, 80: 5413-5422.
23. Vasiljeva L, Merits A, Golubtsov A, Sizemskaja V, Ahola T. (2003). Regulation of the sequential processing of Semliki Forest virus replicase polyprotein. Journal of Biological Chemistry, 278: 41636-41645.
2 Protocols published
Enterovirus Competition Assay to Assess Replication Fitness
Authors:  Valeria Lulla and Andrew E. Firth, date: 05/20/2019, view: 3590, Q&A: 0
In virology the difference between the fitness of two viruses can be determined by using various methods, such as virus titer, growth curve analysis, measurement of virus infectivity, analysis of produced RNA copies and viral protein production. ...
IFN-α/β Detection Assay Using Sensor Cell Lines
Authors:  Valeria Lulla, Andres Merits and Aleksei Lulla, date: 05/20/2014, view: 9440, Q&A: 0
Type I interferons (IFN-α/β) play an important role in host resistance to viral infections. Signaling through the JAK-STAT pathway, IFN-α/β stimulates response elements (ISRE) in the promoters of ISG to regulate their expression (reviewed in ...
7 Protocols reviewed
Quantification of Protein Kinase A (PKA) Activity by An in vitro Radioactive Assay Using the Mouse Sperm Derived Enzyme
Authors:  Cintia Stival, Carolina Baro Graf, Pablo E. Visconti and Dario Krapf, date: 06/20/2020, view: 2101, Q&A: 0
In order to acquire fertilizing potential, mammalian sperm must undergo a process known as capacitation, which relies on the early activation of Protein Kinase A (PKA). Frequently, PKA activity is assessed in whole-cell ...
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Pathogenicity Assay of Verticillium nonalfalfae on Hop Plants
Authors:  Marko Flajšman, Sebastjan Radišek and Branka Javornik, date: 03/20/2017, view: 7172, Q&A: 0
Verticillium nonalfalfae is a soil-borne plant pathogen that infects its hosts through roots. It spreads in the plant’s xylem and causes wilt disease symptoms by secreting different virulence factors. Hop (Humulus lupulus) is a ...
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