Search
Coauthors
Linlin Sun Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University School of Medicine, USA, USA,
1 protocol

Joseph Cichon Department of Anesthesiology and Critical Care, University of Pennsylvania, USA, USA,
1 protocol

Michael Bennett Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, USA
1 protocol

Feliksas Bukauskas Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, USA
1 protocol

Guang Yang
  • Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University School of Medicine, USA, USA,
  • 2 Author merit

Education

Ph.D in Biology, Tsinghua University, Beijing, China, 2005

Current position

Associate professor, Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University School of Medicine, New York, NY

Publications

  1. Yang S, Gu C, Mandeville ET, Dong Y, Esposito E, Zhang Y, Yang G, Shen Y, Fu X, Lo E, Xie Z. (2017). Anesthesia and surgery impair blood brain barrier and cognitive function in mice. Front Immunol 8:902.  
  2. Cichon, J., Blanck, T.J.J., Gan, W.B., Yang, G. (2017). Activation of cortical somatostatin interneurons prevents the development of neuropathic pain. Nat Neurosci 2017 20(8): 1122-1132.
  3. Garré, J.M., Moura-Silva, H., Lafaille, J.J., Yang, G. (2017). CX3CR1+ monocytes modulate learning and learning-dependent dendritic spine remodeling via TNF-α. Nat Med 23(6):714-722.
  4. Zhang, Q., Manders, T., Tong, A.P., Yang, R., Garg, A., Martinez, E., Zhou, H., Dale, J., Goyal, A., Urien, L., Yang, G., Chen, Z., Wang, J. (2017). Chronic pain induces generalized enhancement of aversion. eLife pii: e25302.
  5. Li, W., Ma, L., Yang, G., Gan, W.B. (2017). REM sleep selectively prunes and maintains new synapses in development and learning. Nat Neurosci 20(3):427-437
  6. Garré, J.M., Yang, G., Bukauskas, F.F., Bennett, M.V. (2017). An Acute Mouse Spinal Cord Slice Preparation for Studying Glial Activation ex vivo. Bio Protoc 20;7(2).
  7. Huang, L., Hayes, S. and Yang, G. (2016). Long-lasting behavioral effects in neonatal mice with multiple exposures to ketamine-xylazine anesthesia. Neurotoxicol Teratol 60:75-81.
  8. Wang, B., Liu, Y., Huang, L., Chen, J., Li, J. J., Wang, R., Kim, E., Chen, Y., Justicia, C., Sakata, K., Chen, H., Planas, A., Ostrom, R. S., Li, W., Yang, G., McDonald, M. P., Chen, R., Heck, D. H. and Liao, F. F. (2017). A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated mechanism. Mol Psychiatry 22(7): 990-1001.
  9. Huang, L., Hayes, S. and Yang, G. (2016). Long-lasting behavioral effects in neonatal mice with multiple exposures to ketamine-xylazine anesthesia. Neurotoxicol Teratol. [Epub ahead of print]
  10. Wang, B., Liu, Y., Huang, L., Chen, J., Li, J. J., Wang, R., Kim, E., Chen, Y., Justicia, C., Sakata, K., Chen, H., Planas, A., Ostrom, R. S., Li, W., Yang, G., McDonald, M. P., Chen, R., Heck, D. H. and Liao, F. F. (2016). A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated mechanism. Mol Psychiatry. [Epub ahead of print]
  11. Huang, L., Cichon, J., Ninan, I. and Yang, G. (2016). Post-anesthesia AMPA receptor potentiation prevents anesthesia-induced learning and synaptic deficits. Sci Transl Med 8(344): 344ra385.
  12. Garre, J. M., Yang, G., Bukauskas, F. F. and Bennett, M. V. (2016). FGF-1 Triggers Pannexin-1 Hemichannel Opening in Spinal Astrocytes of Rodents and Promotes Inflammatory Responses in Acute Spinal Cord Slices. J Neurosci 36(17): 4785-4801.
  13. Qiao, Q., Ma, L., Li, W., Tsai, J. W., Yang, G. and Gan, W. B. (2016). Long-term stability of axonal boutons in the mouse barrel cortex. Dev Neurobiol 76(3): 252-261.
  14. Ma, L., Qiao, Q., Tsai, J. W., Yang, G., Li, W. and Gan, W. B. (2016). Experience-dependent plasticity of dendritic spines of layer 2/3 pyramidal neurons in the mouse cortex. Dev Neurobiol 76(3): 277-286.
  15. Huang, L. and Yang, G. (2015). Repeated exposure to ketamine-xylazine during early development impairs motor learning-dependent dendritic spine plasticity in adulthood. Anesthesiology 122(4): 821-831.
  16. Yang, G., Lai, C. S., Cichon, J., Ma, L., Li, W. and Gan, W. B. (2014). Sleep promotes branch-specific formation of dendritic spines after learning. Science 344(6188): 1173-1178.
  17. Parkhurst, C. N., Yang, G., Ninan, I., Savas, J. N., Yates, J. R., 3rd, Lafaille, J. J., Hempstead, B. L., Littman, D. R. and Gan, W. B. (2013). Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell 155(7): 1596-1609.
  18. Yang, G., Pan, F., Chang, P. C., Gooden, F. and Gan, W. B. (2013). Transcranial two-photon imaging of synaptic structures in the cortex of awake head-restrained mice. Methods Mol Biol 1010: 35-43.
  19. Yang, G., Parkhurst, C. N., Hayes, S. and Gan, W. B. (2013). Peripheral elevation of TNF-alpha leads to early synaptic abnormalities in the mouse somatosensory cortex in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 110(25): 10306-10311.
  20. Yang, G. and Gan, W. B. (2012). Sleep contributes to dendritic spine formation and elimination in the developing mouse somatosensory cortex. Dev Neurobiol 72(11): 1391-1398.
  21. Grutzendler, J., Yang, G., Pan, F., Parkhurst, C. N. and Gan, W. B. (2011). Transcranial two-photon imaging of the living mouse brain. Cold Spring Harb Protoc 2011(9).
  22. Yang, G., Chang, P. C., Bekker, A., Blanck, T. J. and Gan, W. B. (2011). Transient effects of anesthetics on dendritic spines and filopodia in the living mouse cortex. Anesthesiology 115(4): 718-726.
  23. Yang, G., Pan, F., Parkhurst, C. N., Grutzendler, J. and Gan, W. B. (2010). Thinned-skull cranial window technique for long-term imaging of the cortex in live mice. Nat Protoc 5(2): 201-208.
  24. Yang, G., Pan, F. and Gan, W. B. (2009). Stably maintained dendritic spines are associated with lifelong memories. Nature 462(7275): 920-924.
  25. Xu, H. T., Pan, F., Yang, G. and Gan, W. B. (2007). Choice of cranial window type for in vivo imaging affects dendritic spine turnover in the cortex. Nat Neurosci 10(5): 549-551.
  26. Haynes, S. E., Hollopeter, G., Yang, G., Kurpius, D., Dailey, M. E., Gan, W. B. and Julius, D. (2006). The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci 9(12): 1512-1519.
  27. Yang, G., Gong, Y. D., Gong, K., Jiang, W. L., Kwon, E., Wang, P., Zheng, H., Zhang, X. F., Gan, W. B. and Zhao, N. M. (2005). Reduced synaptic vesicle density and active zone size in mice lacking amyloid precursor protein (APP) and APP-like protein 2. Neurosci Lett 384(1-2): 66-71.
  28. Zuo, Y., Yang, G., Kwon, E. and Gan, W. B. (2005). Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortex. Nature 436(7048): 261-265.
  29. Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L. and Gan, W. B. (2005). ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 8(6): 752-758.
  30. Wang, P., Yang, G., Mosier, D. R., Chang, P., Zaidi, T., Gong, Y. D., Zhao, N. M., Dominguez, B., Lee, K. F., Gan, W. B. and Zheng, H. (2005). Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2. J Neurosci 25(5): 1219-1225.
2 Protocols published
Spared Nerve Injury Model of Neuropathic Pain in Mice
Authors:  Joseph Cichon, Linlin Sun and Guang Yang, date: 03/20/2018, view: 1334, Q&A: 0
Experimental models of peripheral nerve injury have been developed to study mechanisms of neuropathic pain in living animals. The spared nerve injury (SNI) model in rodents is a partial denervation model, in which the common peroneal and tibial ...
An Acute Mouse Spinal Cord Slice Preparation for Studying Glial Activation ex vivo
Authors:  Juan Mauricio Garré, Guang Yang, Feliksas F. Bukauskas and Michael V. L. Bennett, date: 01/20/2017, view: 3731, Q&A: 0
Pathological conditions such as amyotrophic lateral sclerosis, spinal cord injury and chronic pain are characterized by activation of astrocytes and microglia in spinal cord and have been modeled in rodents. In vivo imaging at cellular ...