Matthew Steensma Van Andel Research Institute Grand Rapids
1 protocol

Carrie Graveel Cancer and Cell Biology Van Andel Research Institute
1 protocol

Megan Callaghan Van Andel Research Institute Grand Rapids
1 protocol

Menusha Arumugam Center for Cancer and Cell Biology Van Andel Institue
1 protocol

Curt J Essenburg
  • Van Andel Research Institute Grand Rapids
  • 2 Author merit


B.S. in Biology, Grand Valley State University, 2005

Current Position

Research Technician, Van Andel Research Institute, Michigan, USA


  1. Linklater, E. S., Tovar, E. A., Essenburg, C. J., Turner, L., Madaj, Z., Winn, M. E., Melnik, M. K., Korkaya, H., Maroun, C. R., Christensen, J. G., Steensma, M. R., Boerner, J. L. and Graveel, C. R. (2016). Targeting MET and EGFR crosstalk signaling in triple-negative breast cancers. Oncotarget. [Epub ahead of print]
  2. Sameni, M., Tovar, E. A., Essenburg, C. J., Chalasani, A., Linklater, E. S., Borgman, A., Cherba, D. M., Anbalagan, A., Winn, M. E., Graveel, C. R. and Sloane, B. F. (2016). Cabozantinib (XL184) Inhibits Growth and Invasion of Preclinical TNBC Models. Clin Cancer Res 22(4): 923-934.
  3. Xie, Q., Su, Y., Dykema, K., Johnson, J., Koeman, J., De Giorgi, V., Huang, A., Schlegel, R., Essenburg, C., Kang, L., Iwaya, K., Seki, S., Khoo, S. K., Zhang, B., Buonaguro, F., Marincola, F. M., Furge, K., Vande Woude, G. F. and Shinomiya, N. (2013). Overexpression of HGF Promotes HBV-Induced Hepatocellular Carcinoma Progression and Is an Effective Indicator for Met-Targeting Therapy. Genes Cancer 4(7-8): 247-260.
  4. Zhang, Y. W., Staal, B., Essenburg, C., Lewis, S., Kaufman, D. and Vande Woude, G. F. (2013). Strengthening context-dependent anticancer effects on non-small cell lung carcinoma by inhibition of both MET and EGFR. Mol Cancer Ther 12(8): 1429-1441.
  5. Xie, Q., Bradley, R., Kang, L., Koeman, J., Ascierto, M. L., Worschech, A., De Giorgi, V., Wang, E., Kefene, L., Su, Y., Essenburg, C., Kaufman, D. W., DeKoning, T., Enter, M. A., O'Rourke, T. J., Marincola, F. M. and Vande Woude, G. F. (2012). Hepatocyte growth factor (HGF) autocrine activation predicts sensitivity to MET inhibition in glioblastoma. Proc Natl Acad Sci U S A 109(2): 570-575.
  6. Zhang, Y. W., Staal, B., Essenburg, C., Su, Y., Kang, L., West, R., Kaufman, D., Dekoning, T., Eagleson, B., Buchanan, S. G. and Vande Woude, G. F. (2010). MET kinase inhibitor SGX523 synergizes with epidermal growth factor receptor inhibitor erlotinib in a hepatocyte growth factor-dependent fashion to suppress carcinoma growth. Cancer Res 70(17): 6880-6890.
2 Protocols published
Dissecting the Rat Mammary Gland: Isolation, Characterization, and Culture of Purified Mammary Epithelial Cells and Fibroblasts

With the advent of CRISPR-Cas and the ability to easily modify the genome of diverse organisms, rat models are being increasingly developed to interrogate the genetic events underlying mammary development and tumorigenesis. Protocols for the

In vivo Efficacy Studies in Cell Line and Patient-derived Xenograft Mouse Models
Authors:  Elizabeth A. Tovar, Curt J. Essenburg and Carrie Graveel, date: 01/05/2017, view: 11854, Q&A: 0
In vivo xenograft models derived from human cancer cells have been a gold standard for evaluating the genetic drivers of cancer and are valuable preclinical models for evaluating the efficacy of cancer therapeutics. Recently, ...
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