Cristina Peña Hospital Universitario Ramón y Cajal
1 protocol

Josep Baulida Programa de Recerca en Cáncer, Institut Hospital del mar d’Investigacions Mèdiques, Spain
1 protocol

Félix Bonilla Centro de Estudios Biosanitarios, Spain
1 protocol

Gemma Ferrer-Mayorga Instituto de Investigaciones Biomédicas “Alberto Sols”, Consejo Superio de Investigaciones Científicas, Universidad Autónoma de Madrid, Spain
1 protocol

Antonio García de Herreros
  • Programa de Recerca en Cáncer, Institut Hospital del mar d’Investigacions Mèdiques, Spain
  • 1 Author merit


Ph.D. in Biochemistry, Centro de Biologia Molecular, Universidad Autónoma de Madrid 1985

Current position

Senior Scientist, Insititut Hospital del Mar d’Investigació Mèdica: Professor of Biochemistry, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain


  1. Loubat-Casanovas, J., Pena, R., Gonzalez, N., Alba-Castellon, L., Rosell, S., Franci, C., Navarro, P. and Garcia de Herreros, A. (2016). Snail1 is required for the maintenance of the pancreatic acinar phenotype. Oncotarget 7(4): 4468-4482.
  2. Beltran, M., Aparicio-Prat, E., Mazzolini, R., Millanes-Romero, A., Masso, P., Jenner, R. G., Diaz, V. M., Peiro, S. and de Herreros, A. G. (2015). Splicing of a non-coding antisense transcript controls LEF1 gene expression. Nucleic Acids Res 43(12): 5785-5797.
  3. Frias, A., Lambies, G., Vinas-Castells, R., Martinez-Guillamon, C., Dave, N., Garcia de Herreros, A.* and Diaz, V. M.* (2015). A Switch in Akt Isoforms Is Required for Notch-Induced Snail1 Expression and Protection from Cell Death. Mol Cell Biol 36(6): 923-940. (*Corresponding authors)
  4. Vinas-Castells, R., Frias, A., Robles-Lanuza, E., Zhang, K., Longmore, G. D., Garcia de Herreros, A.* and Diaz, V. M.* (2014). Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability. Nucleic Acids Res 42(2): 1079-1094. (*Corresponding authors)
  5. Vinyoles, M., Del Valle-Perez, B., Curto, J., Vinas-Castells, R., Alba-Castellon, L., Garcia de Herreros, A.* and Dunach, M.* (2014). Multivesicular GSK3 sequestration upon Wnt signaling is controlled by p120-catenin/cadherin interaction with LRP5/6. Mol Cell 53(3): 444-457.
  6. Batlle, R., Alba-Castellon, L., Loubat-Casanovas, J., Armenteros, E., Franci, C., Stanisavljevic, J., Banderas, R., Martin-Caballero, J., Bonilla, F., Baulida, J., Casal, J. I., Gridley, T. and Garcia de Herreros, A. (2013). Snail1 controls TGF-beta responsiveness and differentiation of mesenchymal stem cells. Oncogene 32(28): 3381-3389.
  7. Villagrasa, P., Diaz, V. M., Vinas-Castells, R., Peiro, S., Del Valle-Perez, B., Dave, N., Rodriguez-Asiain, A., Casal, J. I., Lizcano, J. M., Dunach, M.* and Garcia de Herreros, A.* (2012). Akt2 interacts with Snail1 in the E-cadherin promoter. Oncogene 31(36): 4022-4033. (*Corresponding authors)
  8. Dave, N., Guaita-Esteruelas, S., Gutarra, S., Frias, A., Beltran, M., Peiro, S. and de Herreros, A. G. (2011). Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition. J Biol Chem 286(14): 12024-12032.
  9. Del Valle-Perez, B., Casagolda, D., Lugilde, E., Valls, G., Codina, M., Dave, N., de Herreros, A. G.* and Dunach, M.* (2011). Wnt controls the transcriptional activity of Kaiso through CK1epsilon-dependent phosphorylation of p120-catenin. J Cell Sci 124(Pt 13): 2298-2309. (*Corresponding authors)
  10. Del Valle-Perez, B., Arques, O., Vinyoles, M., de Herreros, A. G.* and Dunach, M.* (2011). Coordinated action of CK1 isoforms in canonical Wnt signaling. Mol Cell Biol 31(14): 2877-2888. (*Corresponding authors)
  11. Beltran, M., Puig, I., Pena, C., Garcia, J. M., Alvarez, A. B., Pena, R., Bonilla, F. and de Herreros, A. G. (2008). A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition. Genes Dev 22(6): 756-769.
  12. Piedra, J., Miravet, S., Castano, J., Palmer, H. G., Heisterkamp, N., Garcia de Herreros, A.* and Dunach, M.* (2003). p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction. Mol Cell Biol 23(7): 2287-2297. (*Corresponding authors)
  13. Guaita, S., Puig, I., Franci, C., Garrido, M., Dominguez, D., Batlle, E., Sancho, E., Dedhar, S., De Herreros, A. G.* and Baulida, J.* (2002). Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. J Biol Chem 277(42): 39209-39216. (*Corresponding authors)
  14. Batlle, E., Sancho, E., Franci, C., Dominguez, D., Monfar, M., Baulida, J. and Garcia De Herreros, A. (2000). The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2(2): 84-89.
  15. Roura, S., Miravet, S., Piedra, J., Garcia de Herreros, A.* and Dunach, M.* (1999). Regulation of E-cadherin/Catenin association by tyrosine phosphorylation. J Biol Chem 274(51): 36734-36740. (*Corresponding authors)
1 Protocol published
Colon Cancer-associated Fibroblast Establishment and Culture Growth
Cancer-associated fibroblasts (CAFs) are one of the major players in tumor-stroma crosstalk. Findings in experimental studies suggest important roles for CAFs in regulation of tumor growth, metastasis and drug response (Hanahan and Coussens, 2012). ...
We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.