Cristina Peña Hospital Universitario Ramón y Cajal
1 protocol

Josep Baulida Programa de Recerca en Cáncer, Institut Hospital del mar d’Investigacions Mèdiques, Spain
1 protocol

Félix Bonilla Centro de Estudios Biosanitarios, Spain
1 protocol

Antonio Herreros Programa de Recerca en Cáncer, Institut Hospital del mar d’Investigacions Mèdiques, Spain
1 protocol

Mercedes Herrera
  • Grupo de investigación en “Señalización celular en cáncer”, Hospital Universitario Puerta de Hierro de Majadahonda, Spain
Research focus
  • Cancer biology
  • 1 Author merit


Ph.D. in Genetics and Cell Biology, Departament of Biology, Autónoma University of Madrid, 2014

Current position

Researcher Ph.D. position in the Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

Publications (since 2005)

  1. Stanisavljevic, J., Loubat-Casanovas, J., Herrera, M., Luque, T., Pena, R., Lluch, A., Albanell, J., Bonilla, F., Rovira, A., Pena, C., Navajas, D., Rojo, F., Garcia de Herreros, A. and Baulida, J. (2015). Snail1-expressing fibroblasts in the tumor microenvironment display mechanical properties that support metastasis. Cancer Res 75(2): 284-295.
  2. Torres, S., Garcia-Palmero, I., Herrera, M., Bartolome, R. A., Pena, C., Fernandez-Acenero, M. J., Padilla, G., Pelaez-Garcia, A., Lopez-Lucendo, M., Rodriguez-Merlo, R., Garcia de Herreros, A., Bonilla, F. and Casal, J. I. (2015). LOXL2 Is Highly Expressed in Cancer-Associated Fibroblasts and Associates to Poor Colon Cancer Survival. Clin Cancer Res 21(21): 4892-4902.
  3. Rodriguez, M., Silva, J., Herrera, A., Herrera, M., Pena, C., Martin, P., Gil-Calderon, B., Larriba, M. J., Coronado, M. J., Soldevilla, B., Turrion, V. S., Provencio, M., Sanchez, A., Bonilla, F. and Garcia-Barberan, V. (2015). Exosomes enriched in stemness/metastatic-related mRNAS promote oncogenic potential in breast cancer. Oncotarget 6(38): 40575-40587.
  4. Herrera, A., HERRERA, M., Bonilla, F. and Peña, C. (2014). Fibroblasts SNAIL expression as a paracrine stimulator on pro-tumorogenic abilities of colon cancer cells. Cancer Cell and Microenvironment  e417.
  5. Herrera, A., Herrera, M., Alba-Castellon, L., Silva, J., Garcia, V., Loubat-Casanovas, J., Alvarez-Cienfuegos, A., Miguel Garcia, J., Rodriguez, R., Gil, B., Ma Jesus, C., Ma Jesus, L., Ignacio Casal, J., de Herreros, A. G., Bonilla, F. and Pena, C. (2014). Protumorigenic effects of Snail-expression fibroblasts on colon cancer cells. Int J Cancer 134(12): 2984-2990.
  6. Herrera, M., Herrera, A., Dominguez, G., Silva, J., Garcia, V., Garcia, J. M., Gomez, I., Soldevilla, B., Munoz, C., Provencio, M., Campos-Martin, Y., Garcia de Herreros, A., Casal, I., Bonilla, F. and Pena, C. (2013). Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients. Cancer Sci 104(4): 437-444.
  7. Herrera, M., Islam, A. B., Herrera, A., Martin, P., Garcia, V., Silva, J., Garcia, J. M., Salas, C., Casal, I., de Herreros, A. G., Bonilla, F. and Pena, C. (2013). Functional heterogeneity of cancer-associated fibroblasts from human colon tumors shows specific prognostic gene expression signature. Clin Cancer Res 19(21): 5914-5926.
  8. Herrero-Barbudo, C., Soldevilla, B., Perez-Sacristan, B., Blanco-Navarro, I., Herrera, M., Granado-Lorencio, F. and Dominguez, G. (2013). Modulation of DNA-induced damage and repair capacity in humans after dietary intervention with lutein-enriched fermented milk. PLoS One 8(9): e74135.
  9. Silva, J., Garcia, V., Rodriguez, M., Compte, M., Cisneros, E., Veguillas, P., Garcia, J. M., Dominguez, G., Campos-Martin, Y., Cuevas, J., Pena, C., Herrera, M., Diaz, R., Mohammed, N. and Bonilla, F. (2012). Analysis of exosome release and its prognostic value in human colorectal cancer. Genes Chromosomes Cancer 51(4): 409-418.
  10. Alvarez-Diaz, S., Valle, N., Ferrer-Mayorga, G., Lombardia, L., Herrera, M., Dominguez, O., Segura, M. F., Bonilla, F., Hernando, E. and Munoz, A. (2012). MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells. Hum Mol Genet 21(10): 2157-2165.
  11. Silva, J., Garcia, V., Zaballos, A., Provencio, M., Lombardia, L., Almonacid, L., Garcia, J. M., Dominguez, G., Pena, C., Diaz, R., Herrera, M., Varela, A. and Bonilla, F. (2011). Vesicle-related microRNAs in plasma of nonsmall cell lung cancer patients and correlation with survival. Eur Respir J 37(3): 617-623.
  12. Gomez, I., Pena, C., Herrera, M., Munoz, C., Larriba, M. J., Garcia, V., Dominguez, G., Silva, J., Rodriguez, R., Garcia de Herreros, A., Bonilla, F. and Garcia, J. M. (2011). TWIST1 is expressed in colorectal carcinomas and predicts patient survival. PLoS One 6(3): e18023.
  13. Mohammed, N., Rodriguez, M., Garcia, V., Garcia, J. M., Dominguez, G., Pena, C., Herrera, M., Gomez, I., Diaz, R., Soldevilla, B., Herrera, A., Silva, J. and Bonilla, F. (2011). EPAS1 mRNA in plasma from colorectal cancer patients is associated with poor outcome in advanced stages. Oncol Lett 2(4): 719-724.
  14. Soldevilla, B., Diaz, R., Silva, J., Campos-Martin, Y., Munoz, C., Garcia, V., Garcia, J. M., Pena, C., Herrera, M., Rodriguez, M., Gomez, I., Mohamed, N., Marques, M. M., Bonilla, F. and Dominguez, G. (2011). Prognostic impact of DeltaTAp73 isoform levels and their target genes in colon cancer patients. Clin Cancer Res 17(18): 6029-6039.
  15. Diaz, R., Gonzalez-Sancho, J. M., Soldevilla, B., Silva, J., Garcia, J. M., Garcia, V., Pena, C., Herrera, M., Gomez, I., Bonilla, F. and Dominguez, G. (2010). Differential regulation of TP73 isoforms by 1alpha,25-dihydroxyvitamin D3 and survivin in human colon and breast carcinomas. Genes Chromosomes Cancer 49(12): 1135-1142.
  16. Herrera, M., Dominguez, G., Garcia, J. M., Pena, C., Jimenez, C., Silva, J., Garcia, V., Gomez, I., Diaz, R., Martin, P. and Bonilla, F. (2009). Differences in repair of DNA cross-links between lymphocytes and epithelial tumor cells from colon cancer patients measured in vitro with the comet assay. Clin Cancer Res 15(17): 5466-5472.
  17. Lorenzo, Y., Provencio, M., Lombardia, L., Diaz, R., Silva, J., Herrera, M., Garcia, J. M., Pena, C., Garcia, V., Romero, J., Dominguez, G. and Bonilla, F. (2009). Differential genetic and functional markers of second neoplasias in Hodgkin's disease patients. Clin Cancer Res 15(15): 4823-4828.
  18. Pena, C., Garcia, J. M., Larriba, M. J., Barderas, R., Gomez, I., Herrera, M., Garcia, V., Silva, J., Dominguez, G., Rodriguez, R., Cuevas, J., de Herreros, A. G., Casal, J. I., Munoz, A. and Bonilla, F. (2009). SNAI1 expression in colon cancer related with CDH1 and VDR downregulation in normal adjacent tissue. Oncogene 28(49): 4375-4385.
  19. Garcia, V., Garcia, J. M., Silva, J., Martin, P., Pena, C., Dominguez, G., Diaz, R., Herrera, M., Maximiano, C., Sabin, P., Rueda, A., Cruz, M. A., Rodriguez, J., Canales, M. A., Bonilla, F. and Provencio, M. (2009). Extracellular tumor-related mRNA in plasma of lymphoma patients and survival implications. PLoS One 4(12): e8173.
  20. Medina-Arana, V., Barrios, Y., Fernandez-Peralta, A., Herrera, M., Chinea, N., Lorenzo, N., Jimenez, A., Martin-Lopez, J. V., Gonzalez-Hermoso, F., Salido, E. and Gonzalez-Aguilera, J. J. (2006). New founding mutation in MSH2 associated with hereditary nonpolyposis colorectal cancer syndrome on the Island of Tenerife. Cancer Lett 244(2): 268-273.
1 Protocol published
Colon Cancer-associated Fibroblast Establishment and Culture Growth
Cancer-associated fibroblasts (CAFs) are one of the major players in tumor-stroma crosstalk. Findings in experimental studies suggest important roles for CAFs in regulation of tumor growth, metastasis and drug response (Hanahan and Coussens, 2012). ...
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