Yong Lin Molecular Biology and Lung Cancer, Lovelace Respiratory Research Institute, USA
1 protocol

Mabel Padilla Molecular Biology and Lung Cancer, Lovelace Respiratory Research Institute, USA
1 protocol

Xiuling Xu
  • Molecular Biology and Lung Cancer, Lovelace Respiratory Research Institute, USA
Research focus
  • Immunology
  • 1 Author merit


Ph.D. in Biomaterials and Biomedical Sciences, State key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 2007

Current position

Associate Research Scientist, Molecular Biology and Lung Cancer Program, Lovelace
Respiratory Research Institute, Albuquerque, NM

Publications (selected)

  1. Xu, X., Wells, A., Padilla, M. T., Kato, K., Kim, K. C. and Lin, Y. (2014). A signaling pathway consisting of miR-551b, catalase and MUC1 contributes to acquired apoptosis resistance and chemoresistance. Carcinogenesis: bgu159.
  2. Xu, X., Padilla, M. T., Li, B., Wells, A., Kato, K., Tellez, C., Belinsky, S. A., Kim, K. C. and Lin, Y. (2014). MUC1 in macrophage: contributions to cigarette smoke-induced lung cancer. Cancer Res 74(2): 460-470.
  3. Wang, Q., Chen, W., Xu, X., Li, B., He, W., Padilla, M. T., Jang, J. H., Nyunoya, T., Amin, S., Wang, X. and Lin, Y. (2013). RIP1 potentiates BPDE-induced transformation in human bronchial epithelial cells through catalase-mediated suppression of excessive reactive oxygen species. Carcinogenesis 34(9): 2119-2128.
  4. Chen, W., Xu, X., Bai, L., Padilla, M. T., Gott, K. M., Leng, S., Tellez, C. S., Wilder, J. A., Belinsky, S. A., Scott, B. R. and Lin, Y. (2012). Low-dose gamma-irradiation inhibits IL-6 secretion from human lung fibroblasts that promotes bronchial epithelial cell transformation by cigarette-smoke carcinogen. Carcinogenesis 33(7): 1368-1374.
  5. Xu, X., Bai, L., Chen, W., Padilla, M. T., Liu, Y., Kim, K. C., Belinsky, S. A. and Lin, Y. (2012). MUC1 contributes to BPDE-induced human bronchial epithelial cell transformation through facilitating EGFR activation. PLoS One 7(3): e33846.
  6. Bai, L., Xu, X., Wang, Q., Xu, S., Ju, W., Wang, X., Chen, W., He, W., Tang, H. and Lin, Y. (2012). A superoxide-mediated mitogen-activated protein kinase phosphatase-1 degradation and c-Jun NH(2)-terminal kinase activation pathway for luteolin-induced lung cancer cytotoxicity. Mol Pharmacol 81(4): 549-555.
  7. He, W., Wang, Q., Xu, J., Xu, X., Padilla, M. T., Ren, G., Gou, X. and Lin, Y. (2012). Attenuation of TNFSF10/TRAIL-induced apoptosis by an autophagic survival pathway involving TRAF2-and RIPK1/RIP1-mediated MAPK8/JNK activation. Autophagy 8(12): 1811-1821.
  8.  Li, Z .⃰, Xu, X .⃰, Bai, L., Chen, W. and Lin, Y. (2011). Epidermal growth factor receptor-mediated tissue transglutaminase overexpression couples acquired tumor necrosis factor-related apoptosis-inducing ligand resistance and migration through c-FLIP and MMP-9 proteins in lung cancer cells. J Biol Chem 286(24): 21164-21172. Authors contributed equally to the work
  9. Xu, X., Davis, K. A., Yang, P., Gu, X., Henderson, J. H. and Mather, P. T. (2011). Shape Memory RGD‐Containing Networks: Synthesis, Characterization, and Application in Cell Culture. Macromolecular Symposia, Wiley Online Library.
  10. Wang, Z., Sun, Y., Han, H., Xu, X., Jing, X. (2011). Nano-fiber-mediated paclitaxel combined with doxorubicin for sequential chemotherapy of SHg-44 glioma. Journal of Clinical Rehabilitative Tissue Engineering Research, 15 (12): 2179-2182.
  11. Xing, M., Zhong, W., Xu, X. and Thomson, D. (2010). Adhesion force studies of nanofibers and nanoparticles. Langmuir 26(14): 11809-11814.
  12. Xu, X., Zhong, W., Zhou, S., Trajtman, A. and Alfa, M. (2010). Electrospun PEG–PLA nanofibrous membrane for sustained release of hydrophilic antibiotics. Journal of applied polymer science 118(1): 588-595.
  13. Xu, X., Chen, X., Wang, Z. and Jing, X. (2009). Ultrafine PEG-PLA fibers loaded with both paclitaxel and doxorubicin hydrochloride and their in vitro cytotoxicity. Eur J Pharm Biopharm 72(1): 18-25.
  14. Xu, X., Chen, X., Ma, P., Wang, X. and Jing, X. (2008). The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning. Eur J Pharm Biopharm 70(1): 165-170.
  15. Xu, X., Chen, X., Liu, A., Hong, Z. and Jing, X. (2007). Electrospun poly (L-lactide)-grafted hydroxyapatite/poly (L-lactide) nanocomposite fibers. European polymer journal 43(8): 3187-3196.
  16. Xu, X., Zhuang, X., Chen, X., Wang, X., Yang, L. and Jing, X. (2006). Preparation of Core‐Sheath Composite Nanofibers by Emulsion Electrospinning. Macromolecular rapid communications 27(19): 1637-1642.
  17. Wang, Z., Luo, Y., Guo, H., Li, Y., Xu, X. and Hai, H. (2007). Application of paclitaxel-poly (ethylene glycol)-poly (D,L-lactic acid) controlled-release ultrafine fibers against brain glioma in rat models. Journal of Clinical Rehabilitative Tissue Engineering Research 11(35): 6970-6973.
  18. Xu, X., Chen, X., Xu, X., Lu, T., Wang, X., Yang, L. and Jing, X. (2006). BCNU-loaded PEG-PLLA ultrafine fibers and their in vitro antitumor activity against Glioma C6 cells. J Control Release 114(3): 307-316.
  19. Xu, X., Yang, L., Xu, X., Wang, X., Chen, X., Liang, Q., Zeng, J. and Jing, X. (2005). Ultrafine medicated fibers electrospun from W/O emulsions. J Control Release 108(1): 33-42.
  20. Zeng, J., Yang, L., Liang, Q., Zhang, X., Guan, H., Xu, X., Chen, X. and Jing, X. (2005). Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation. J Control Release 105(1-2): 43-51.
  21. Zeng, J., Chen, X., Liang, Q., Xu, X. and Jing, X. (2004). Enzymatic degradation of poly(L-lactide) and poly(epsilon-caprolactone) electrospun fibers. Macromol Biosci 4(12): 1118-1125.
1 Protocol published
Authors:  Xiuling Xu, Mabel T. Padilla and Yong Lin, date: 10/20/2014, view: 7602, Q&A: 0
In cigarette smoke–induced and inflammation-associated lung cancer development, cigarette smoke extract (CSE) activates tumor necrosis factor-alpha (TNF-α) secretion from macrophages. TNF-α converting enzyme (TACE), also known as α-Secretase or ...
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