Abhinit Nagar UMass Medical School, Worcestor, MA
3 protocols

Ali Kermani University of Michigan, Ann Arbor
6 protocols

Amberley Stephens Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge
2 protocols

Aswad Khadilkar UNIVERSITY OF CALIFORNIA SANTA CRUZ
11 protocols

Editor
Alessandro Didonna
  • Assistant Adjunct Professor, University of California, San Francisco
Research focus
  • Neuroscience
  • Neurodegeneration; Multiple Sclerosis; Autoimmunity; Protein Misfolding; Movement Disorders.
  • 0 Author merit

Education

Ph.D. in Functional and Structural Genomics, International School for Advanced Studies (SISSA), 2010

Lab information

Multiple Sclerosis Genetics Research Lab

Publications

1. The novel multiple sclerosis susceptibility gene ATXN1 regulates B cell receptor signaling in B-1a cells. Mol Brain. 2021 Jan 21; 14(1):19.Ma Q, Didonna A. PMID: 33478569.

2. A splice acceptor variant in HLA-DRA affects the conformation and cellular localization of the class II DR alpha-chain. Immunology. 2021 Feb; 162(2):194-207.Didonna A, Damotte V, Shams H, Matsunaga A, Caillier SJ, Dandekar R, Misra MK, Mofrad MRK, Oksenberg JR, Hollenbach JA. PMID: 32986852.

3. Oligodendrocyte-specific Argonaute profiling identifies microRNAs associated with experimental autoimmune encephalomyelitis. J Neuroinflammation. 2020 Oct 12; 17(1):297.Ma Q, Matsunaga A, Ho B, Oksenberg JR, Didonna A. PMID: 33046105.

4. Tau at the interface between neurodegeneration and neuroinflammation. Genes Immun. 2020 11; 21(5):288-300.Didonna A. PMID: 33011744.

5. Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis. Proc Natl Acad Sci USA. 2020 09 22; 117(38):23742-23750.Didonna A, Canto Puig E, Ma Q, Matsunaga A, Ho B, Caillier SJ, Shams H, Lee N, Hauser SL, Tan Q, Zamvil SS, Oksenberg JR. PMID: 32878998.

6. TopoDB: a novel multifunctional management system for laboratory animal colonies. Database (Oxford). 2020 Jan 01; 2020.Renschen A, Matsunaga A, Oksenberg JR, Santaniello A, Didonna A. PMID: 33206961.

7. Mitoma H. Manto M. (eds) Neuroimmune Diseases. Contemporary Clinical Neuroscience. Genetic Factors in Neuroimmune Diseases. 2019; 357-386 .Didonna A,
Cantó E. View Publication.

8. The role of neurofilament aggregation in neurodegeneration: lessons from rare inherited neurological disorders. Mol Neurodegener. 2019 05 16; 14(1):19.Didonna A, Opal P. PMID: 31097008.

9. Sex-specific Tau methylation patterns and synaptic transcriptional alterations are associated with neural vulnerability during chronic neuroinflammation. J Autoimmun. 2019 07; 101:56-69.Didonna A, Cantó E, Shams H, Isobe N, Zhao C, Caillier SJ, Condello C, Yamate-Morgan H, Tiwari-Woodruff SK, Mofrad MRK, Hauser SL, Oksenberg JR. PMID: 31010726.

10. Loss of the dystonia gene Thap1 leads to transcriptional deficits that converge on common pathogenic pathways in dystonic syndromes. Hum Mol Genet. 2019 04 15; 28(8):1343-1356.Frederick NM, Shah PV, Didonna A, Langley MR, Kanthasamy AG, Opal P. PMID: 30590536.

11. Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1. J Clin Invest. 2018 06 01; 128(6):2252-2265.Edamakanti CR, Do J, Didonna A, Martina M, Opal P. PMID: 29533923.

12. Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients. J Neuroinflammation. 2018 Mar 07; 15(1):72.Canto E, Isobe N, Didonna A, Hauser SL, Oksenberg JR. PMID: 29514694.

13. The Genetics of Multiple Sclerosis. Multiple Sclerosis: Perspectives in Treatment and Pathogenesis. 2017 Nov 14; 3-16.ALESSANDRO DIDONNA, JORGE R. OKSENBERG. .

14. Hyperpolarized 13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model. Proc Natl Acad Sci USA. 2017 08 15; 114(33):E6982-E6991.Guglielmetti C, Najac C, Didonna A, Van der Linden A, Ronen SM, Chaumeil MM. PMID: 28760957.

15. Advances in Sequencing Technologies for Understanding Hereditary Ataxias: A Review. JAMA Neurol. 2016 Dec 01; 73(12):1485-1490.Didonna A, Opal P. PMID: 27749953.

16. Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis. Sci Rep. 2016 08 22; 6:31603.Didonna A, Cekanaviciute E, Oksenberg JR, Baranzini SE. PMID: 27546286.

17. Preclinical Models of Multiple Sclerosis: Advantages and Limitations Towards Better Therapies. Curr Med Chem. 2016; 23(14):1442-59.Didonna A. PMID: 27048376.

18. A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome. Hum Mol Genet. 2015 Dec 15; 24(24):7151-8.Didonna A, Isobe N, Caillier SJ, Li KH, Burlingame AL, Hauser SL, Baranzini SE, Patsopoulos NA, Oksenberg JR. PMID: 26433934.

19. Characterization of four new monoclonal antibodies against the distal N-terminal region of PrP(c). PeerJ. 2015; 3:e811.Didonna A, Venturini AC, Hartman K, Vranac T, Curin Šerbec V, Legname G. PMID: 25802800.

20. Genetic determinants of risk and progression in multiple sclerosis. Clin Chim Acta. 2015 Sep 20; 449:16-22.Didonna A, Oksenberg JR. PMID: 25661088.

21. Post-translational modifications in neurodegeneration. AIMS Biophysics. 2015 Jan 1; 3(1):27-49.Alessandro Didonna, Federico Benetti. .

22. The promise and perils of HDAC inhibitors in neurodegeneration. Ann Clin Transl Neurol. 2015 Jan; 2(1):79-101.Didonna A, Opal P. PMID: 25642438.

23. The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1. Hum Mol Genet. 2014 Jul 15; 23(14):3733-45.Venkatraman A, Hu YS, Didonna A, Cvetanovic M, Krbanjevic A, Bilesimo P, Opal P. PMID: 24594842.

24. Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation. J Clin Invest. 2013 May; 123(5):1964-75.Mahammad S, Murthy SN, Didonna A, Grin B, Israeli E, Perrot R, Bomont P, Julien JP, Kuczmarski E, Opal P, Goldman RD. PMID: 23585478.

25. Prion protein and its role in signal transduction. Cell Mol Biol Lett. 2013 Jun; 18(2):209-30.Didonna A. PMID: 23479001.

26. The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells. Prion. 2012 Jul 01; 6(3):309-16.Didonna A, Sussman J, Benetti F, Legname G. PMID: 22561161.

27. Infrared microspectroscopy: a multiple-screening platform for investigating single-cell biochemical perturbations upon prion infection. ACS Chem Neurosci. 2011 Mar 16; 2(3):160-74.Didonna A, Vaccari L, Bek A, Legname G. PMID: 22778865.

28. Aberrant ERK 1/2 complex activation and localization in scrapie-infected GT1-1 cells. Mol Neurodegener. 2010 Aug 09; 5:29.Didonna A, Legname G. PMID: 20696038.
6 Protocols reviewed
Development of the Deoxycorticosterone Acetate (DOCA)-salt Hypertensive Rat Model
Authors:  Nayara Pestana-Oliveira, David B. Nahey, Tim Johnson and John P. Collister, date: 08/05/2020, view: 1716, Q&A: 0
According to the World Health Organization (WHO), nearly 1.13 billion people worldwide have hypertension, a major factor responsible for premature death globally. The inherent multifactorial nature of hypertension makes its study difficult since the ...
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Induction of Temporal Lobe Epilepsy in Mice with Pilocarpine
Authors:  Muhammad Nauman Arshad and Janice R Naegele, date: 02/20/2020, view: 2678, Q&A: 0
In the pilocarpine model of temporal lobe epilepsy (TLE) in rodents, systemic injections of pilocarpine induce continuous, prolonged limbic seizures, a condition termed “Status Epilepticus” (SE). With appropriate doses, many inbred strains of mice ...
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40 Protocols edited
COVID-19 Sample Pooling: From RNA Extraction to Quantitative Real-time RT-PCR

The COVID-19 pandemic requires mass screening to identify those infected for isolation and quarantine. Individually screening large populations for the novel pathogen, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is costly and

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A Robust Mammary Organoid System to Model Lactation and Involution-like Processes
Authors:  Elsa Charifou, Jakub Sumbal, Zuzana Koledova, Han Li and Aurélie Chiche, date: 04/20/2021, view: 729, Q&A: 0

The mammary gland is a highly dynamic tissue that changes throughout reproductive life, including growth during puberty and repetitive cycles of pregnancy and involution. Mammary gland tumors represent the most common cancer diagnosed in women

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