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Coreviewers
Edel Hennessy University of Edinburgh
4 protocols

José Dias Karolinska Institutet
1 protocol

Michael Tscherner Harvard Medical School
5 protocols

Mirko Messa Yale University School of Medicine Department of Neuroscience
3 protocols

Editor
Alessandro Didonna
  • Adjunct Instructor, University of California, San Francisco
Research focus
  • Neuroscience
  • Neurodegeneration; Multiple Sclerosis; Autoimmunity; Protein Misfolding; Movement Disorders.
  • 0 Author merit

Education

Ph.D. in Functional and Structural Genomics, International School for Advanced Studies (SISSA), 2010

Lab information

Multiple Sclerosis Genetics Research Lab

Publications

1. Didonna A, Oksenberg JR. Multiple Sclerosis: Perspectives in Treatment and Pathogenesis. Ian S. Zagon and Patricia J. McLaughlin (Editors). The Genetics of Multiple Sclerosis. 2017; 3-16.

2. Guglielmetti C, Najac C, Didonna A, Van der Linden A, Ronen SM, Chaumeil MM. Hyperpolarized 13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model. Proc Natl Acad Sci U S A. 2017 Aug 15; 114(33):E6982-E6991.

3. Didonna A, Opal P. Advances in Sequencing Technologies for Understanding Hereditary Ataxias: A Review. JAMA Neurol. 2016 Dec 01; 73(12):1485-1490.

4. Didonna A, Cekanaviciute E, Oksenberg JR, Baranzini SE. Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis. Sci Rep. 2016 Aug 22; 6:31603.

5. Didonna A, Benetti F. Post-translational modifications in neurodegeneration. AIMS Biophysics. 2016; 1(3):27-49.

6. Didonna A. Preclinical Models of Multiple Sclerosis: Advantages and Limitations Towards Better Therapies. Curr Med Chem. 2016; 23(14):1442-59.

7. Didonna A, Isobe N, Caillier SJ, Li KH, Burlingame AL, Hauser SL, Baranzini SE, Patsopoulos NA, Oksenberg JR. A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome. Hum Mol Genet. 2015 Dec 15; 24(24):7151-8.

8. Didonna A, Venturini AC, Hartman K, Vranac T, Curin Šerbec V, Legname G. Characterization of four new monoclonal antibodies against the distal N-terminal region of PrP(c). PeerJ. 2015; 3:e811.

9. Didonna A, Oksenberg JR. Genetic determinants of risk and progression in multiple sclerosis. Clin Chim Acta. 2015 Sep 20; 449:16-22.

10. Didonna A, Opal P. The promise and perils of HDAC inhibitors in neurodegeneration. Ann Clin Transl Neurol. 2015 Jan; 2(1):79-101.

11. Venkatraman A, Hu YS, Didonna A, Cvetanovic M, Krbanjevic A, Bilesimo P, Opal P. The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1. Hum Mol Genet. 2014 Jul 15; 23(14):3733-45.

12. Mahammad S, Murthy SN, Didonna A, Grin B, Israeli E, Perrot R, Bomont P, Julien JP, Kuczmarski E, Opal P, Goldman RD. Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation. J Clin Invest. 2013 May; 123(5):1964-75.

13. Didonna A. Prion protein and its role in signal transduction. Cell Mol Biol Lett. 2013 Jun; 18(2):209-30.

14. Didonna A, Sussman J, Benetti F, Legname G. The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells. Prion. 2012 Jul 01; 6(3):309-16.

15. Didonna A, Vaccari L, Bek A, Legname G. Infrared microspectroscopy: a multiple-screening platform for investigating single-cell biochemical perturbations upon prion infection. ACS Chem Neurosci. 2011 Mar 16; 2(3):160-74.

16. Didonna A, Legname G. Aberrant ERK 1/2 complex activation and localization in scrapie-infected GT1-1 cells. Mol Neurodegener. 2010 Aug 09; 5:29.

4 Protocols reviewed
Common Carotid Arteries Occlusion Surgery in Adult Rats as a Model of Chronic Cerebral Hypoperfusion
Authors:  Dandan Cao, Yunfei Bai and Liang Li, date: 01/20/2018, view: 41, Q&A: 0
Chronic cerebral hypoperfusion (CCH) is an important risk factor of vascular dementia (VaD) and Alzheimer’s disease (AD). Hypoxia/ischemia in the whole brain induced by CCH causes serious damage to brain structure and function, which can lead to ...
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A Novel Protocol to Quantitatively Measure the Endocytic Trafficking of Amyloid Precursor Protein (APP) in Polarized Primary Neurons with Sub-cellular Resolution
Authors:  Florent Ubelmann, Tatiana Burrinha and Cláudia Guimas Almeida, date: 12/05/2017, view: 459, Q&A: 0
Alzheimer’s disease’s established primary trigger is β-amyloid (Aβ) (Mucke and Selkoe, 2012). The amyloid precursor protein (APP) endocytosis is required for Aβ generation at early endosomes (Rajendran and Annaert, 2012). APP retention at endosomes ...
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5 Protocols edited
Bacteria-fungal Confrontation and Fungal Growth Prevention Assay
There are some bacteria which can grow and multiply at the cost of living fungal biomass. They can potentially utilize fungi as a source of nutrients to forage over them. Such phenomenon is known as bacterial mycophagy, however, its mechanistic ...
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Visible Immunoprecipitation (VIP) Assay: a Simple and Versatile Method for Visual Detection of Protein-protein Interactions
Authors:  Yohei Katoh, Kentaro Nakamura and Kazuhisa Nakayama, date: 01/05/2018, view: 296, Q&A: 0
The visible immunoprecipitation (VIP) assay is a convenient alternative to conventional co-immunoprecipitation (Katoh et al., 2015). By processing lysates from cells co-expressing GFP-fusion and RFP-fusion proteins for immunoprecipitation ...
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