Search
Paula Hurley The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins School of Medicine, USA
1 protocol

Brian Simons The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins School of Medicine, USA
1 protocol

Robert M. Hughes
  • The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins School of Medicine, USA
  • 1 Author merit

Education

B.S. Biochemistry, University of Maryland, College Park, MD, 2010

Current position

MD-PhD Student, Johns Hopkins University School of Medicine

Publications

  1. Goldstein, A., Valda Toro, P., Lee, J., Silberstein, J. L., Nakazawa, M., Waters, I., Cravero, K., Chu, D., Cochran, R. L., Kim, M., Shinn, D., Torquato, S., Hughes, R. M., Pallavajjala, A., Carducci, M. A., Paller, C. J., Denmeade, S. R., Kressel, B., Trock, B. J., Eisenberger, M. A., Antonarakis, E. S., Park, B. H. and Hurley, P. J. (2017). Detection fidelity of AR mutations in plasma derived cell-free DNA. Oncotarget.
  2. Maughan, B. L., Suzman, D. L., Luber, B., Wang, H., Glavaris, S., Hughes, R., Sullivan, R., Harb, R., Boudadi, K., Paller, C., Eisenberger, M., Demarzo, A., Ross, A. and Antonarakis, E. S. (2016). Pharmacodynamic study of the oral hedgehog pathway inhibitor, vismodegib, in patients with metastatic castration-resistant prostate cancer. Cancer Chemother Pharmacol 78(6): 1297-1304.
  3. Fertig, E. J., Ozawa, H., Thakar, M., Howard, J. D., Kagohara, L. T., Krigsfeld, G., Ranaweera, R. S., Hughes, R. M., Perez, J., Jones, S., Favorov, A. V., Carey, J., Stein-O'Brien, G., Gaykalova, D. A., Ochs, M. F. and Chung, C. H. (2016). CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network. Oncotarget 7(45): 73845-73864.
  4. Hurley, P. J., Sundi, D., Shinder, B., Simons, B. W., Hughes, R. M., Miller, R. M., Benzon, B., Faraj, S. F., Netto, G. J., Vergara, I. A., Erho, N., Davicioni, E., Karnes, R. J., Yan, G., Ewing, C., Isaacs, S. D., Berman, D. M., Rider, J. R., Jordahl, K. M., Mucci, L. A., Huang, J., An, S. S., Park, B. H., Isaacs, W. B., Marchionni, L., Ross, A. E. and Schaeffer, E. M. (2016). Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer. Clin Cancer Res 22(2): 448-458.
  5. Hurley, P. J., Hughes, R. M., Simons, B. W., Huang, J., Miller, R. M., Shinder, B., Haffner, M. C., Esopi, D., Kimura, Y., Jabbari, J., Ross, A. E., Erho, N., Vergara, I. A., Faraj, S. F., Davicioni, E., Netto, G. J., Yegnasubramanian, S., An, S. S. and Schaeffer, E. M. (2015). Androgen-Regulated SPARCL1 in the Tumor Microenvironment Inhibits Metastatic Progression. Cancer Res 75(20): 4322-4334.
  6. Hasumi, H., Baba, M., Hasumi, Y., Huang, Y., Oh, H., Hughes, R. M., Klein, M. E., Takikita, S., Nagashima, K., Schmidt, L. S. and Linehan, W. M. (2012). Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN. J Natl Cancer Inst 104(22): 1750-1764.
  7. Baba, M., Keller, J. R., Sun, H. W., Resch, W., Kuchen, S., Suh, H. C., Hasumi, H., Hasumi, Y., Kieffer-Kwon, K. R., Gonzalez, C. G., Hughes, R. M., Klein, M. E., Oh, H. F., Bible, P., Southon, E., Tessarollo, L., Schmidt, L. S., Linehan, W. M. and Casellas, R. (2012). The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dube syndrome is required for murine B-cell development. Blood 120(6): 1254-1261.
  8. Zhang, D. L., Hughes, R. M., Ollivierre-Wilson, H., Ghosh, M. C. and Rouault, T. A. (2009). A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression. Cell Metab 9(5): 461-473.
  9. Li, K., Tong, W. H., Hughes, R. M. and Rouault, T. A. (2006). Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly. J Biol Chem 281(18): 12344-12351.
1 Protocol published
A Murine Orthotopic Allograft to Model Prostate Cancer Growth and Metastasis
Authors:  Robert M. Hughes, Brian W. Simons and Paula J. Hurley, date: 02/20/2017, view: 4220, Q&A: 0
Prostate cancer is one of the most common cancers in men in the United States. Comprehensive understanding of the biology contributing to prostate cancer will have important clinical implications. Animal models have greatly impacted our knowledge of ...