Jae Im CRUK-MRC Oxford Institute for Radiation Oncology, University of Oxford, UK
1 protocol

Ruth J. Muschel
  • CRUK-MRC Oxford Institute for Radiation Oncology, University of Oxford, UK
Research focus
  • Cancer biology
  • 1 Author merit


Ph.D in Cell Biology, Albert Einstein College of Medicine, 1978

Current position

Professor, Dept. Oncology, Deputy Director, CRUK/MRC Oxford Institute for Radiation Therapy, University of Oxford

Publications (since 2010)

  1. Lim, S. Y., Yuzhalin, A. E., Gordon-Weeks, A. N. and Muschel, R. J. (2016). Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells. Oncogene 35(44): 5735-5745.
  2. Tapmeier, T. T., Moshnikova, A., Beech, J., Allen, D., Kinchesh, P., Smart, S., Harris, A., McIntyre, A., Engelman, D. M., Andreev, O. A., Reshetnyak, Y. K. and Muschel, R. J. (2015). The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions. Proc Natl Acad Sci U S A 112(31): 9710-9715.
  3. Lim, S. Y., Gordon-Weeks, A., Allen, D., Kersemans, V., Beech, J., Smart, S. and Muschel, R. J. (2015). Cd11b(+) myeloid cells support hepatic metastasis through down-regulation of angiopoietin-like 7 in cancer cells. Hepatology 62(2): 521-533.
  4. Im, J. H., Tapmeier, T., Balathasan, L., Gal, A., Yameen, S., Hill, S., Smart, S., Noterdaeme, O., Kelly, M., Brady, M., Fu, W., Kruse, K., Bernhard, E. J., Augustin, H. G. and Muschel, R. J. (2013). G-CSF rescues tumor growth and neo-angiogenesis during liver metastasis under host angiopoietin-2 deficiency. Int J Cancer 132(2): 315-326.
  5. Ferjancic, S., Gil-Bernabe, A. M., Hill, S. A., Allen, P. D., Richardson, P., Sparey, T., Savory, E., McGuffog, J. and Muschel, R. J. (2013). VCAM-1 and VAP-1 recruit myeloid cells that promote pulmonary metastasis in mice. Blood 121(16): 3289-3297.
  6. Zhao, L., Lim, S. Y., Gordon-Weeks, A. N., Tapmeier, T. T., Im, J. H., Cao, Y., Beech, J., Allen, D., Smart, S. and Muschel, R. J. (2013). Recruitment of a myeloid cell subset (CD11b/Gr1 mid) via CCL2/CCR2 promotes the development of colorectal cancer liver metastasis. Hepatology 57(2): 829-839.
  7. McKee, C. M., Xu, D., Cao, Y., Kabraji, S., Allen, D., Kersemans, V., Beech, J., Smart, S., Hamdy, F., Ishkanian, A., Sykes, J., Pintile, M., Milosevic, M., van der Kwast, T., Zafarana, G., Ramnarine, V. R., Jurisica, I., Mallof, C., Lam, W., Bristow, R. G. and Muschel, R. J. (2012). Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma. J Clin Invest 122(11): 4025-4036.
  8. Gil-Bernabe, A. M., Ferjancic, S., Tlalka, M., Zhao, L., Allen, P. D., Im, J. H., Watson, K., Hill, S. A., Amirkhosravi, A., Francis, J. L., Pollard, J. W., Ruf, W. and Muschel, R. J. (2012). Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice. Blood 119(13): 3164-3175.
  9. Fokas, E., Im, J. H., Hill, S., Yameen, S., Stratford, M., Beech, J., Hackl, W., Maira, S. M., Bernhard, E. J., McKenna, W. G. and Muschel, R. J. (2012). Dual inhibition of the PI3K/mTOR pathway increases tumor radiosensitivity by normalizing tumor vasculature. Cancer Res 72(1): 239-248.
  10. Liu, S. K., Bham, S. A., Fokas, E., Beech, J., Im, J., Cho, S., Harris, A. L. and Muschel, R. J. (2011). Delta-like ligand 4-notch blockade and tumor radiation response. J Natl Cancer Inst 103(23): 1778-1798.
1 Protocol published
Authors:  Jae Hong Im and Ruth J. Muschel, date: 02/20/2017, view: 15787, Q&A: 1
Platelets and coagulation have long been known to be essential for metastasis in experimental models. In order to study the interactions between tumor cells, platelets and endothelium, we have adapted methods used in coagulation research for the ...
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