Julia Lorenzo Institut de Biotecnologia i de Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Campus Universitari, Bellaterra, Cerdanyola del Vallès, Spain
1 protocol

Walter Obregon Centro de Investigación de Proteínas Vegetales, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina
1 protocol

Francesc Avilés Institut de Biotecnologia i de Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Campus Universitari, Bellaterra, Cerdanyola del Vallès, Spain
1 protocol

Laura Bakas Centro de Investigación de Proteínas Vegetales, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina
1 protocol

Sebastián Tanco
  • Medical Biotechnology Center, VIB, Belgium
  • 1 Author merit

Education

Ph.D. in Protein Structure and Function, Institut de Biotecnologia i de Biomedicina, Universitat Autonoma de Barcelona, 2012

Current Position

Postdoctoral researcher at the Medical Biotechnology Center – VIB and at the Department of Biochemistry, Ghent University, Ghent, Belgium

Publications

  1. Lufrano, D., Cotabarren, J., Garcia-Pardo, J., Fernandez-Alvarez, R., Tort, O., Tanco, S., Aviles, F. X., Lorenzo, J. and Obregon, W. D. (2015). Biochemical characterization of a novel carboxypeptidase inhibitor from a variety of Andean potatoes. Phytochemistry 120: 36-45.
  2. Fait, M. E., Garrote, G. L., Clapes, P., Tanco, S., Lorenzo, J. and Morcelle, S. R. (2015). Biocatalytic synthesis, antimicrobial properties and toxicity studies of arginine derivative surfactants. Amino Acids 47(7): 1465-1477.
  3. Tanco, S., Gevaert, K. and Van Damme, P. (2015). C-terminomics: Targeted analysis of natural and posttranslationally modified protein and peptide C-termini. Proteomics 15(5-6): 903-914.
  4. Tanco, S., Tort, O., Demol, H., Aviles, F. X., Gevaert, K., Van Damme, P. and Lorenzo, J. (2015). C-terminomics screen for natural substrates of cytosolic carboxypeptidase 1 reveals processing of acidic protein C termini. Mol Cell Proteomics 14(1): 177-190.
  5. Tort, O., Tanco, S., Rocha, C., Bieche, I., Seixas, C., Bosc, C., Andrieux, A., Moutin, M. J., Aviles, F. X., Lorenzo, J. and Janke, C. (2014). The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids. Mol Biol Cell 25(19): 3017-3027.
  6. Tanco, S., Lorenzo, J., Garcia-Pardo, J., Degroeve, S., Martens, L., Aviles, F. X., Gevaert, K. and Van Damme, P. (2013). Proteome-derived peptide libraries to study the substrate specificity profiles of carboxypeptidases. Mol Cell Proteomics 12(8): 2096-2110.
  7. Otero, A., Rodriguez de la Vega, M., Tanco, S., Lorenzo, J., Aviles, F. X. and Reverter, D. (2012). The novel structure of a cytosolic M14 metallocarboxypeptidase (CCP) from Pseudomonas aeruginosa: a model for mammalian CCPs. FASEB J 26(9): 3754-3764.
  8. Benitez, J., Becco, L., Correia, I., Leal, S. M., Guiset, H., Pessoa, J. C., Lorenzo, J., Tanco, S., Escobar, P., Moreno, V., Garat, B. and Gambino, D. (2011). Vanadium polypyridyl compounds as potential antiparasitic and antitumoral agents: new achievements. J Inorg Biochem 105(2): 303-312.
  9. Tanco, S., Zhang, X., Morano, C., Aviles, F. X., Lorenzo, J. and Fricker, L. D. (2010). Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing. J Biol Chem 285(24): 18385-18396.
  10. Tanco, S., Arolas, J. L., Guevara, T., Lorenzo, J., Aviles, F. X. and Gomis-Ruth, F. X. (2010). Structure-function analysis of the short splicing variant carboxypeptidase encoded by Drosophila melanogaster silver. J Mol Biol 401(3): 465-477.
  11. Rodriguez de la Vega, M., Sevilla, R. G., Hermoso, A., Lorenzo, J., Tanco, S., Diez, A., Fricker, L. D., Bautista, J. M. and Aviles, F. X. (2007). Nna1-like proteins are active metallocarboxypeptidases of a new and diverse M14 subfamily. FASEB J 21(3): 851-865.
  12. Benitez, G., Vericat, C., Tanco, S., Remes Lenicov, F., Castez, M. F., Vela, M. E. and Salvarezza, R. C. (2004). Role of surface heterogeneity and molecular interactions in the charge-transfer process through self-assembled thiolate monolayers on Au(111). Langmuir 20(12): 5030-5037.
  13. Vericat, C., Remes Lenicov, F., Tanco, S., Andreasen, G., Vázquez, L., Vela, M. E. and Salvarezza, RC (2003). Binary self-assembled of alkanethiols on Au(111) studied by STM. Acta Microscopica 12: 78-82.
  14. Vericat, C., Remes Lenicov, F., Tanco, S., Andreasen, G.., Vela, M. E. and Salvarezza, R. C. (2002). Building complex twodimensional structures: methylene blue on self-assembled monolayer-covered Au(111). Journal of Physical Chemistry B 106: 9114-9121.
1 Protocol published
Microplate Assay to Study Carboxypeptidase A Inhibition in Andean Potatoes
Metallocarboxypeptidases (MCP) are zinc-dependent exopeptidases that catalyze the hydrolysis of C-terminal amide bonds in proteins and peptides. They are involved in a wide range of physiological processes and have recently emerged as relevant drug ...
We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.