Education

Ph.D in Biochemistry, School of Life Sciences, Sun Yat-sen University, 1995

Current position

Professor in School of Life Sciences, Sun Yat-sen University, Guangzhou, China

Publications

1. Wang, X. D., Gong, Y., Chen, Z. L., Gong, B. N., Xie, J. J., Zhong, C. Q., Wang, Q. L., Diao, L. H., Xu, A., Han, J., Altman, A. and Li, Y. (2015). TCR-induced sumoylation of the kinase PKC-theta controls T cell synapse organization and T cell activation. Nat Immunol 16(11): 1195-1203.

2. Yu, X., Wang, Q. L., Li, Y. F., Wang, X. D., Xu, A. and Li, Y. (2016). A novel miR-200b-3p/p38IP pair regulates monocyte/macrophage differentiation. Cell Discov 2: 15043.

3. Liu, X., Xiao, W., Wang, X. D., Li, Y. F., Han, J. and Li, Y. (2013). The p38-interacting protein (p38IP) regulates G2/M progression by promoting alpha-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5. J Biol Chem 288(51): 36648-36661.

4. Xie, J. J., Liang, J. Q., Diao, L. H., Altman, A. and Li, Y. (2013). TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter. J Immunol 190(8): 4027-4036.

5. Wang, K., Diao, L. H., Gong, Y., Liu, X. and Li, Y. (2012). NEMO differentially regulates TCR and TNF-alpha induced NF-kappaB pathways and has an inhibitory role in TCR-induced NF-kappaB activation. Cell Signal 24(8): 1556-1564.

6. Zohn, I. E., Li, Y., Skolnik, E. Y., Anderson, K. V., Han, J. and Niswander, L. (2006). p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell 125(5): 957-969.

7. Li, Y., Sedwick, C. E., Hu, J. and Altman, A. (2005). Role for protein kinase Ctheta (PKCtheta) in TCR/CD28-mediated signaling through the canonical but not the non-canonical pathway for NF-kappaB activation. J Biol Chem 280(2): 1217-1223.

8. Li, Y., Hu, J., Vita, R., Sun, B., Tabata, H. and Altman, A. (2004). SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway. EMBO J 23(5): 1112-1122.

9. New, L., Li, Y., Ge, B., Zhong, H., Mansbridge, J., Liu, K. and Han, J. (2001). SB203580 promotes EGF-stimulated early morphological differentiation in PC12 cell through activating ERK pathway. J Cell Biochem 83(4): 585-596.

10. Li, Y., Jiang, B., Ensign, W. Y., Vogt, P. K. and Han, J. (2000). Myogenic differentiation requires signalling through both phosphatidylinositol 3-kinase and p38 MAP kinase. Cell Signal 12(11-12): 751-757.

11. New, L., Zhao, M., Li, Y., Bassett, W. W., Feng, Y., Ludwig, S., Padova, F. D., Gram, H. and Han, J. (1999). Cloning and characterization of RLPK, a novel RSK-related protein kinase. J Biol Chem 274(2): 1026-1032.