Catherine Hedrick Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, USA
2 protocols

Richard Hanna MedImmune
2 protocols

Grzegorz Chodaczek
  • Microscopy Core, La Jolla Institute for Allergy and Immunology, USA
Research focus
  • Cancer biology
  • 1 Author merit


Ph.D in Immunology, Institute of Immunology and Experimental Therapy of Polish Academy of Sciences, Wroclaw, Poland, 2007

Current position

Head of Confocal Microscopy Laboratory, Wroclaw Research Centre EIT+, Wroclaw, Poland

Publications (since 2005)

  1. Drabik, D., Przybylo, M., Chodaczek, G., Iglic, A. and Langner, M. (2016). The modified fluorescence based vesicle fluctuation spectroscopy technique for determination of lipid bilayer bending properties. Biochim Biophys Acta 1858(2): 244-252.

  2. Shaked, I., Hanna, R. N., Shaked, H., Chodaczek, G., Nowyhed, H. N., Tweet, G., Tacke, R., Basat, A. B., Mikulski, Z., Togher, S., Miller, J., Blatchley, A., Salek-Ardakani, S., Darvas, M., Kaikkonen, M. U., Thomas, G. D., Lai-Wing-Sun, S., Rezk, A., Bar-Or, A., Glass, C. K., Bandukwala, H. and Hedrick, C. C. (2015). Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation. Nat Immunol 16(12): 1228-1234.

  3. Hanna, R. N., Cekic, C., Sag, D., Tacke, R., Thomas, G. D., Nowyhed, H., Herrley, E., Rasquinha, N., McArdle, S., Wu, R., Peluso, E., Metzger, D., Ichinose, H., Shaked, I., Chodaczek, G., Biswas, S. K. and Hedrick, C. C. (2015). Patrolling monocytes control tumor metastasis to the lung. Science 350(6263): 985-990.

  4. McArdle, S., Chodaczek, G., Ray, N. and Ley, K. (2015). Intravital live cell triggered imaging system reveals monocyte patrolling and macrophage migration in atherosclerotic arteries. J Biomed Opt 20(2): 26005.

  5. Mikulski, Z., Johnson, R., Shaked, I., Kim, G., Nowyhed, H., Goodman, W., Chodaczek, G., Pizarro, T. T., Cominelli, F. and Ley, K. (2015). SAMP1/YitFc mice develop ileitis via loss of CCL21 and defects in dendritic cell migration. Gastroenterology 148(4): 783-793 e785.

  6. Vicente-Suarez, I., Larange, A., Reardon, C., Matho, M., Feau, S., Chodaczek, G., Park, Y., Obata, Y., Gold, R., Wang-Zhu, Y., Lena, C., Zajonc, D. M., Schoenberger, S. P., Kronenberg, M. and Cheroutre, H. (2015). Unique lamina propria stromal cells imprint the functional phenotype of mucosal dendritic cells. Mucosal Immunol 8(1): 141-151.

  7. Verma, S., Wang, Q., Chodaczek, G. and Benedict, C. A. (2013). Lymphoid-tissue stromal cells coordinate innate defense to cytomegalovirus. J Virol 87(11): 6201-6210.

  8. Ariotti, S., Beltman, J. B., Chodaczek, G., Hoekstra, M. E., van Beek, A. E., Gomez-Eerland, R., Ritsma, L., van Rheenen, J., Maree, A. F., Zal, T., de Boer, R. J., Haanen, J. B. and Schumacher, T. N. (2012). Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen. Proc Natl Acad Sci U S A 109(48): 19739-19744.

  9. Koltsova, E. K., Garcia, Z., Chodaczek, G., Landau, M., McArdle, S., Scott, S. R., von Vietinghoff, S., Galkina, E., Miller, Y. I., Acton, S. T. and Ley, K. (2012). Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosis. J Clin Invest 122(9): 3114-3126.

  10. Chodaczek, G., Papanna, V., Zal, M. A. and Zal, T. (2012). Body-barrier surveillance by epidermal gammadelta TCRs. Nat Immunol 13(3): 272-282.

  11. Zal, T. and Chodaczek, G. (2010). Intravital imaging of anti-tumor immune response and the tumor microenvironment. Semin Immunopathol 32(3): 305-317.

  12. Chodaczek, G., Bacsi, A., Dharajiya, N., Sur, S., Hazra, T. K. and Boldogh, I. (2009). Ragweed pollen-mediated IgE-independent release of biogenic amines from mast cells via induction of mitochondrial dysfunction. Mol Immunol 46(13): 2505-2514.

  13. Chodaczek, G., Zimecki, M., Lukasiewicz, J. and Lugowski, C. (2008). Lactoferrin-monophosphoryl lipid A complex enhances immunity of mice to Plesiomonas shigelloides CNCTC 138/92. Acta Biochim Pol 55(1): 91-96.

  14. Bacsi, A., Chodaczek, G., Hazra, T. K., Konkel, D. and Boldogh, I. (2007). Increased ROS generation in subsets of OGG1 knockout fibroblast cells. Mech Ageing Dev 128(11-12): 637-649.

  15. Zimecki, M., Artym, J., Chodaczek, G., Kocieba, M., Kuryszko, J., Houszka, M. and Kruzel, M. L. (2007). Immunoregulatory function of lactoferrin in immunosuppressed and autoimmune animals. Postepy Hig Med Dosw (Online) 61: 283-287.

  16. Chodaczek, G., Saavedra-Molina, A., Bacsi, A., Kruzel, M. L., Sur, S. and Boldogh, I. (2007). Iron-mediated dismutation of superoxide anion augments antigen-induced allergic inflammation: effect of lactoferrin. Postepy Hig Med Dosw (Online) 61: 268-276.

  17. Zimecki, M., Kocieba, M., Chodaczek, G., Houszka, M. and Kruzel, M. L. (2007). Lactoferrin ameliorates symptoms of experimental encephalomyelitis in Lewis rats. J Neuroimmunol 182(1-2): 160-166.

  18. Chodaczek, G., Zimecki, M., Lukasiewicz, J. and Lugowski, C. (2006). A complex of lactoferrin with monophosphoryl lipid A is an efficient adjuvant of the humoral and cellular immune response in mice. Med Microbiol Immunol 195(4): 207-216.

  19. Zimecki, M., Ryng, S., Maczynski, M., Chodaczek, G., Kocieba, M., Kuryszko, J. and Kaleta, K. (2006). Immunosuppressory activity of an isoxazolo[5,4-e]triazepine-compound RM-33 II. Effects on the carrageenan-induced inflammation. Pharmacol Rep 58(2): 236-241.

  20. Zimecki, M., Artym, J., Chodaczek, G., Kocieba, M. and Kruzel, M. (2005). Effects of lactoferrin on the immune response modified by the immobilization stress. Pharmacol Rep 57(6): 811-817.

  21. Ryng, S., Zimecki, M., Maczynski, M., Chodaczek, G. and Kocieba, M. (2005). Immunosuppressive activity of an isoxazolo[5,4-e]triazepine--compound RM33. I. Effects on the humoral and cellular immune response in mice. Pharmacol Rep 57(2): 195-202.

1 Protocol published
In vivo Imaging of Tumor and Immune Cell Interactions in the Lung
Authors:  Richard N. Hanna, Grzegorz Chodaczek and Catherine C. Hedrick, date: 10/20/2016, view: 7402, Q&A: 0
Immunotherapy has demonstrated great therapeutic potential by activating the immune system to fight cancer. However, little is known about the specific dynamics of interactions that occur between tumor and immune cells. In this protocol we describe ...
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