Rachel Caspi Laboratory of Immunology, National Eye Institute, NIH, USA
1 protocol

Phyllis Silver Laboratory of Immunology, National Eye Institute, NIH, USA
1 protocol

Carlos Zárate-Bladés Laboratory of Immunoregulation, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, Brazil
1 protocol

Patricia Dillenburg-Pilla Department of Cell Biology, Embryology and Genetics, Federal University of Santa Catarina, Florianopolis, Brazil
1 protocol

Reiko Horai
  • Laboratory of Immunology, National Eye Institute, NIH, USA
Research focus
  • Immunology
  • 1 Author merit


Ph.D in Molecular Biology, University of Tokyo, Tokyo, Japan, 1998

Current position

Staff Scientist, Laboratory of Immunology, National Eye Institute, NIH, Bethesda, MD


  1. Horai, R., Zarate-Blades, C. R., Dillenburg-Pilla, P., Chen, J., Kielczewski, J. L., Silver, P. B., Jittayasothorn, Y., Chan, C. C., Yamane, H., Honda, K. and Caspi, R. R. (2015). Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site. Immunity 43(2): 343-353.

  2. Silver, P. B., Horai, R., Chen, J., Jittayasothorn, Y., Chan, C. C., Villasmil, R., Kesen, M. R. and Caspi, R. R. (2015). Retina-specific T regulatory cells bring about resolution and maintain remission of autoimmune uveitis. J Immunol 194(7): 3011-3019.

  3. Chong, W. P., Horai, R., Mattapallil, M. J., Silver, P. B., Chen, J., Zhou, R., Sergeev, Y., Villasmil, R., Chan, C. C. and Caspi, R. R. (2014). IL-27p28 inhibits central nervous system autoimmunity by concurrently antagonizing Th1 and Th17 responses. J Autoimmun 50: 12-22.

  4. Horai, R., Silver, P. B., Chen, J., Agarwal, R. K., Chong, W. P., Jittayasothorn, Y., Mattapallil, M. J., Nguyen, S., Natarajan, K., Villasmil, R., Wang, P., Karabekian, Z., Lytton, S. D., Chan, C. C. and Caspi, R. R. (2013). Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen. J Autoimmun 44: 21-33.

  5. Agarwal, R. K., Horai, R., Viley, A. M., Silver, P. B., Grajewski, R. S., Su, S. B., Yazdani, A. T., Zhu, W., Kronenberg, M., Murray, P. J., Rutschman, R. L., Chan, C. C. and Caspi, R. R. (2008). Abrogation of anti-retinal autoimmunity in IL-10 transgenic mice due to reduced T cell priming and inhibition of disease effector mechanisms. J Immunol 180(8): 5423-5429.

  6. Ohsugi, M., Adachi, K., Horai, R., Kakuta, S., Sudo, K., Kotaki, H., Tokai-Nishizumi, N., Sagara, H., Iwakura, Y. and Yamamoto, T. (2008). Kid-mediated chromosome compaction ensures proper nuclear envelope formation. Cell 132(5): 771-782.

  7. Horai, R., Mueller, K. L., Handon, R. A., Cannons, J. L., Anderson, S. M., Kirby, M. R. and Schwartzberg, P. L. (2007). Requirements for selection of conventional and innate T lymphocyte lineages. Immunity 27(5): 775-785.

  8. Broussard, C., Fleischacker, C., Horai, R., Chetana, M., Venegas, A. M., Sharp, L. L., Hedrick, S. M., Fowlkes, B. J. and Schwartzberg, P. L. (2006). Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity 25(1): 93-104.

  9. Matsuki, T., Isoda, K., Horai, R., Nakajima, A., Aizawa, Y., Suzuki, K., Ohsuzu, F. and Iwakura, Y. (2005). Involvement of tumor necrosis factor-alpha in the development of T cell-dependent aortitis in interleukin-1 receptor antagonist-deficient mice. Circulation 112(9): 1323-1331.

  10. Takesono, A., Horai, R., Mandai, M., Dombroski, D. and Schwartzberg, P. L. (2004). Requirement for Tec kinases in chemokine-induced migration and activation of Cdc42 and Rac. Curr Biol 14(10): 917-922.

  11. Horai, R., Nakajima, A., Habiro, K., Kotani, M., Nakae, S., Matsuki, T., Nambu, A., Saijo, S., Kotaki, H., Sudo, K., Okahara, A., Tanioka, H., Ikuse, T., Ishii, N., Schwartzberg, P. L., Abe, R. and Iwakura, Y. (2004). TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice. J Clin Invest 114(11): 1603-1611.

  12. Matsuki, T., Horai, R., Sudo, K. and Iwakura, Y. (2003). IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions. J Exp Med 198(6): 877-888.

  13. Nakae, S., Saijo, S., Horai, R., Sudo, K., Mori, S. and Iwakura, Y. (2003). IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc Natl Acad Sci U S A 100(10): 5986-5990.

  14. Horai, R., Saijo, S., Tanioka, H., Nakae, S., Sudo, K., Okahara, A., Ikuse, T., Asano, M. and Iwakura, Y. (2000). Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice. J Exp Med 191(2): 313-320.

  15. Horai, R., Asano, M., Sudo, K., Kanuka, H., Suzuki, M., Nishihara, M., Takahashi, M. and Iwakura, Y. (1998). Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion. J Exp Med 187(9): 1463-1475.

1 Protocol published
Preparation of Protein-containing Extracts from Microbiota-rich Intestinal Contents
The contribution of microbiota in regulating multiple physiological and pathological host responses has been studied intensively in recent years. Evidence suggests that commensal microbiota can directly modulate different populations of cells of the ...
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