Rodolphe Soret University of Quebec at Montreal
1 protocol

Nicolas Pilon
  • Molecular Genetics of Development Laboratory, Department of Biological Sciences; BioMed Research Center, Faculty of Sciences, University of Quebec at Montreal (UQAM), Canada
Research focus
  • Neuroscience
  • 1 Author merit


Ph.D. in Université de Montréal, Canada, 2001

Current position

Associate Professor, Département des sciences biologiques, Université du Québec à Montréal (UQAM), Montreal (PQ), Canada


  1. Pilon, N. (2016). Pigmentation-based insertional mutagenesis is a simple and potent screening approach for identifying neurocristopathy-associated genes in mice. Rare Dis 4(1): e1156287.

  2. Sanchez-Ferras, O., Bernas, G., Farnos, O., Toure, A. M., Souchkova, O. and Pilon, N. (2016). A direct role for murine Cdx proteins in the trunk neural crest gene regulatory network. Development 143(8): 1363-1374.

  3. Soret, R., Mennetrey, M., Bergeron, K. F., Dariel, A., Neunlist, M., Grunder, F., Faure, C., Silversides, D. W., Pilon, N. and Ente-Hirsch Study, G. (2015). A collagen VI-dependent pathogenic mechanism for Hirschsprung's disease. J Clin Invest 125(12): 4483-4496.

  4. Bergeron, K. F., Cardinal, T., Toure, A. M., Beland, M., Raiwet, D. L., Silversides, D. W. and Pilon, N. (2015). Male-biased aganglionic megacolon in the TashT mouse line due to perturbation of silencer elements in a large gene desert of chromosome 10. PLoS Genet 11(3): e1005093.

  5. Sanchez-Ferras, O., Bernas, G., Laberge-Perrault, E. and Pilon, N. (2014). Induction and dorsal restriction of Paired-box 3 (Pax3) gene expression in the caudal neuroectoderm is mediated by integration of multiple pathways on a short neural crest enhancer. Biochim Biophys Acta 1839(7): 546-558.

  6. Bergeron, K. F., Cardinal, T. and Pilon, N. (2013). A quantitative cell migration assay for murine enteric neural progenitors. J Vis Exp(79): e50709.

  7. Coutaud, B. and Pilon, N. (2013). Characterization of a novel transgenic mouse line expressing Cre recombinase under the control of the Cdx2 neural specific enhancer. Genesis 51(11): 777-784.

  8. Bergeron, K. F., Silversides, D. W. and Pilon, N. (2013). The developmental genetics of Hirschsprung's disease. Clin Genet 83(1): 15-22.

  9. Silversides, D. W., Raiwet, D. L., Souchkova, O., Viger, R. S. and Pilon, N. (2012). Transgenic mouse analysis of Sry expression during the pre- and peri-implantation stage. Dev Dyn 241(7): 1192-1204.

  10. Sanchez-Ferras, O., Coutaud, B., Djavanbakht Samani, T., Tremblay, I., Souchkova, O. and Pilon, N. (2012). Caudal-related homeobox (Cdx) protein-dependent integration of canonical Wnt signaling on paired-box 3 (Pax3) neural crest enhancer. J Biol Chem 287(20): 16623-16635.

  11. Boulende Sab, A., Bouchard, M. F., Beland, M., Prud'homme, B., Souchkova, O., Viger, R. S. and Pilon, N. (2011). An Ebox element in the proximal Gata4 promoter is required for Gata4 expression in vivo. PLoS One 6(12): e29038.

  12. Savory, J. G., Pilon, N., Grainger, S., Sylvestre, J. R., Beland, M., Houle, M., Oh, K. and Lohnes, D. (2009). Cdx1 and Cdx2 are functionally equivalent in vertebral patterning. Dev Biol 330(1): 114-122.

  13. Pilon, N., Raiwet, D., Viger, R. S. and Silversides, D. W. (2008). Novel pre- and post-gastrulation expression of Gata4 within cells of the inner cell mass and migratory neural crest cells. Dev Dyn 237(4): 1133-1143.

  14. Cory, A. T., Boyer, A., Pilon, N., Lussier, J. G. and Silversides, D. W. (2007). Presumptive pre-Sertoli cells express genes involved in cell proliferation and cell signalling during a critical window in early testis differentiation. Mol Reprod Dev 74(12): 1491-1504.

  15. Pilon, N., Oh, K., Sylvestre, J. R., Savory, J. G. and Lohnes, D. (2007). Wnt signaling is a key mediator of Cdx1 expression in vivo. Development 134(12): 2315-2323.

  16. Mazaud Guittot, S., Tetu, A., Legault, E., Pilon, N., Silversides, D. W. and Viger, R. S. (2007). The proximal Gata4 promoter directs reporter gene expression to sertoli cells during mouse gonadal development. Biol Reprod 76(1): 85-95.

  17. Pilon, N., Oh, K., Sylvestre, J. R., Bouchard, N., Savory, J. and Lohnes, D. (2006). Cdx4 is a direct target of the canonical Wnt pathway. Dev Biol 289(1): 55-63.

  18. Boyer, A., Pilon, N., Raiwet, D. L., Lussier, J. G. and Silversides, D. W. (2006). Human and pig SRY 5' flanking sequences can direct reporter transgene expression to the genital ridge and to migrating neural crest cells. Dev Dyn 235(3): 623-632.

  19. Beland, M., Pilon, N., Houle, M., Oh, K., Sylvestre, J. R., Prinos, P. and Lohnes, D. (2004). Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex. Mol Cell Biol 24(11): 5028-5038.

  20. Pilon, N., Daneau, I., Paradis, V., Hamel, F., Lussier, J. G., Viger, R. S. and Silversides, D. W. (2003). Porcine SRY promoter is a target for steroidogenic factor 1. Biol Reprod 68(4): 1098-1106.

  21. Daneau, I., Pilon, N., Boyer, A., Behdjani, R., Overbeek, P. A., Viger, R., Lussier, J. and Silversides, D. W. (2002). The porcine SRY promoter is transactivated within a male genital ridge environment. Genesis 33(4): 170-180.

  22. Silversides, D. W., Pilon, N., Behdjani, R., Boyer, A., Daneau, I. and Lussier, J. (2001). Genetic manipulation of sex differentiation and phenotype in domestic animals. Theriogenology 55(1): 51-63.

  23. Boerboom, D., Pilon, N., Behdjani, R., Silversides, D. W. and Sirois, J. (2000). Expression and regulation of transcripts encoding two members of the NR5A nuclear receptor subfamily of orphan nuclear receptors, steroidogenic factor-1 and NR5A2, in equine ovarian cells during the ovulatory process. Endocrinology 141(12): 4647-4656.

  24. Pilon, N., Behdjani, R., Daneau, I., Lussier, J. G. and Silversides, D. W. (1998). Porcine steroidogenic factor-1 gene (pSF-1) expression and analysis of embryonic pig gonads during sexual differentiation. Endocrinology 139(9): 3803-3812.

  25. Pilon, N., Daneau, I., Brisson, C., Ethier, J. F., Lussier, J. G. and Silversides, D. W. (1997). Porcine and bovine steroidogenic acute regulatory protein (StAR) gene expression during gestation. Endocrinology 138(3): 1085-1091.

  26. Bouffard, P., Gagnon, C., Cloutier, D., MacLean, S. J., Souleimani, A., Nallainathan, D., Home, W. A., Pilon, N. and Gibson, D. M. (1995). Analysis of T cell receptor beta chain expression by isoelectric focusing following gene amplification and in vitro translation. J Immunol Methods 187(1): 9-21.

1 Protocol published
Analysis of Enteric Neural Crest Cell Migration Using Heterotopic Grafts of Embryonic Guts
Authors:  Rodolphe Soret and Nicolas Pilon, date: 09/05/2016, view: 5991, Q&A: 0
Hirschsprung disease (HSCR), also named aganglionic megacolon, is a severe congenital malformation characterized by a lack of enteric nervous system (ENS) in the terminal regions of the bowel (Bergeron et al., 2013). As the ENS notably ...
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