Céline Vallot University Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, France
1 protocol

Claire Rougeulle
  • University Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, France
Research focus
  • Stem cell
  • 1 Author merit


PhD, University Pierre et Marie Curie, Paris, 1996

Current position

Research Director, CNRS.
Group Leader, Team « Non-coding RNAs, Differentiation and Development », Epigenetics and Cell Fate Institute, Paris Diderot University.
Adjunct Assistant Professor, University of Connecticut.

Publications (since 2011)

  1. Ouimette, J. F. and Rougeulle, C. (2016). How many non-coding RNAs does it take to compensate male/female genetic imbalance? In: Wilhelm, D. and Bernard, P. (eds). Non-coding RNAs and the reproductive system, Advance in Experimental Medicine and Biology,  Springer.

  2. Chen, H., Aksoy, I., Gonnot, F., Osteil, P., Aubry, M., Hamela, C., Rognard, C., Hochard, A., Voisin, S., Fontaine, E., Mure, M., Afanassieff, M., Cleroux, E., Guibert, S., Chen, J., Vallot, C., Acloque, H., Genthon, C., Donnadieu, C., De Vos, J., Sanlaville, D., Guerin, J. F., Weber, M., Stanton, L. W., Rougeulle, C., Pain, B., Bourillot, P. Y. and Savatier, P. (2015). Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency. Nat Commun 6: 7095.

  3. Vallot, C., Ouimette, J. F., Makhlouf, M., Feraud, O., Pontis, J., Come, J., Martinat, C., Bennaceur-Griscelli, A., Lalande, M. and Rougeulle, C. (2015). Erosion of X Chromosome Inactivation in Human Pluripotent Cells Initiates with XACT Coating and Depends on a Specific Heterochromatin Landscape. Cell Stem Cell 16(5): 533-546.

  4. Lazorthes, S., Vallot, C., Briois, S., Aguirrebengoa, M., Thuret, J. Y., St Laurent, G., Rougeulle, C., Kapranov, P., Mann, C., Trouche, D. and Nicolas, E. (2015). A vlincRNA participates in senescence maintenance by relieving H2AZ-mediated repression at the INK4 locus. Nat Commun 6: 5971.

  5. Makhlouf, M., Ouimette, J. F., Oldfield, A., Navarro, P., Neuillet, D. and Rougeulle, C. (2014). A prominent and conserved role for YY1 in Xist transcriptional activation. Nat Commun 5: 4878.

  6. Häfner, S. and Rougeulle, C. (2013). La matière noire du génome. Pour la Science, 81: 58-63.

  7. Vallot, C. and Rougeulle, C. (2013). Long non-coding RNAs and human X-chromosome regulation: a coat for the active X chromosome. RNA Biol 10(8): 1262-1265.

  8. Vallot, C. and Rougeulle, C. (2013). [X chromosome inactivation in human: XACT and XIST, a non coding RNA for each X]. Med Sci (Paris) 29(2): 223-225.

  9. Vallot, C., Huret, C., Lesecque, Y., Resch, A., Oudrhiri, N., Bennaceur-Griscelli, A., Duret, L. and Rougeulle, C. (2013). XACT, a long noncoding transcript coating the active X chromosome in human pluripotent cells. Nat Genet 45(3): 239-241.

  10. Vallot, C. and Rougeulle, C. (2012). Epigenetic stability of human pluripotent stem cells. Epigenomics: From Chromatin Biology to Therapeutic 118-133.

  11. Romito, A. and Rougeulle, C. (2011). Origin and evolution of the long non-coding genes in the X-inactivation center. Biochimie 93(11): 1935-1942.

  12. Makhlouf, M. and Rougeulle, C. (2011). Linking X chromosome inactivation to pluripotency: Necessity or fate? Trends Mol Med 17(6): 329-336.

  13. Chureau, C., Chantalat, S., Romito, A., Galvani, A., Duret, L., Avner, P. and Rougeulle, C. (2011). Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region. Hum Mol Genet 20(4): 705-718.

  14. Navarro, P., Oldfield, A., Legoupi, J., Festuccia, N., Dubois, A., Attia, M., Schoorlemmer, J., Rougeulle, C., Chambers, I. and Avner, P. (2010). Molecular coupling of Tsix regulation and pluripotency. Nature 468(7322): 457-460.

  15. Mitjavila-Garcia, M. T., Bonnet, M. L., Yates, F., Haddad, R., Oudrhiri, N., Feraud, O., Magniez, A., Makhlouf, M., Vallot, C., Rougeulle, C., Bennaceur-Griscelli, A. and Turhan, A. G. (2010). Partial reversal of the methylation pattern of the X-linked gene HUMARA during hematopoietic differentiation of human embryonic stem cells. J Mol Cell Biol 2(5): 291-298.

  16. Fritsch, L., Robin, P., Mathieu, J. R., Souidi, M., Hinaux, H., Rougeulle, C., Harel-Bellan, A., Ameyar-Zazoua, M. and Ait-Si-Ali, S. (2010). A subset of the histone H3 lysine 9 methyltransferases Suv39h1, G9a, GLP, and SETDB1 participate in a multimeric complex. Mol Cell 37(1): 46-56.

  17. Oldfield, A. and Rougeulle, C. (2009). X-plications sur le contrôle de l’inactivation : la régulation du gène Xist. Biofutur 304 : 28-31.

  18. Navarro, P., Chantalat, S., Foglio, M., Chureau, C., Vigneau, S., Clerc, P., Avner, P. and Rougeulle, C. (2009). A role for non-coding Tsix transcription in partitioning chromatin domains within the mouse X-inactivation centre. Epigenetics Chromatin 2(1): 8.

  19. Rougeulle, C. (2009). Inactivation du chromosome X : Quand les facteurs de pluripotence s’en mêlent. Med Sci (Paris), 25:234-235.

  20. Navarro, P., Chambers, I., Karwacki-Neisius, V., Chureau, C., Morey, C., Rougeulle, C. and Avner, P. (2008). Molecular coupling of Xist regulation and pluripotency. Science 321(5896): 1693-1695.

  21. Navarro, P., Page, D. R., Avner, P. and Rougeulle, C. (2006). Tsix-mediated epigenetic switch of a CTCF-flanked region of the Xist promoter determines the Xist transcription program. Genes Dev 20(20): 2787-2792.

  22. Ciaudo, C., Bourdet, A., Cohen-Tannoudji, M., Dietz, H. C., Rougeulle, C. and Avner, P. (2006). Nuclear mRNA degradation pathway(s) are implicated in Xist regulation and X chromosome inactivation. PLoS Genet 2(6): e94.

  23. Navarro, P., Pichard, S., Ciaudo, C., Avner, P. and Rougeulle, C. (2005). Tsix transcription across the Xist gene alters chromatin conformation without affecting Xist transcription: implications for X-chromosome inactivation. Genes Dev 19(12): 1474-1484.

  24. Landers, M., Bancescu, D. L., Le Meur, E., Rougeulle, C., Glatt-Deeley, H., Brannan, C., Muscatelli, F. and Lalande, M. (2004). Regulation of the large (approximately 1000 kb) imprinted murine Ube3a antisense transcript by alternative exons upstream of Snurf/Snrpn. Nucleic Acids Res 32(11): 3480-3492.

  25. Rougeulle, C. and Avner, P. (2004). The role of antisense transcription in the regulation of X-inactivation. Curr Top Dev Biol 63: 61-89.

  26. Rougeulle, C., Chaumeil, J., Sarma, K., Allis, C. D., Reinberg, D., Avner, P. and Heard, E. (2004). Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome. Mol Cell Biol 24(12): 5475-5484.

  27. Morey, C., Navarro, P., Debrand, E., Avner, P., Rougeulle, C. and Clerc, P. (2004). The region 3' to Xist mediates X chromosome counting and H3 Lys-4 dimethylation within the Xist gene. EMBO J 23(3): 594-604.

  28. Rougeulle, C., Navarro, P. and Avner, P. (2003). Promoter-restricted H3 Lys 4 di-methylation is an epigenetic mark for monoallelic expression. Hum Mol Genet 12(24): 3343-3348.

  29. Rougeulle, C. and Avner, P. (2003). Controlling X-inactivation in mammals: what does the centre hold? Semin Cell Dev Biol 14(6): 331-340.

  30. Rougeulle, C. and Heard, E. (2002). Antisense RNA in imprinting: spreading silence through Air. Trends Genet 18(9): 434-437.

  31. Bourdet, A. and Rougeulle, C. (2002). Inactivation du chromosome X chez la souris: les tendances cis et trans pour la nouvelle année. Med Sci (Paris), 18:532-534.

  32. Heard, E., Rougeulle, C., Arnaud, D., Avner, P., Allis, C. D. and Spector, D. L. (2001). Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation. Cell 107(6): 727-738.

  33. Monier, K., Heliot, L., Rougeulle, C., Heard, E., Robert-Nicoud, M., Vourc'h, C., Bensimon, A. and Usson, Y. (2001). Improvement of FISH mapping resolution on combed DNA molecules by iterative constrained deconvolution: a quantitative study. Cytogenet Cell Genet 92(1-2): 59-62.

1 Protocol published
Single-cell Visualization of Chromosome Transcriptional Territories by RNA-paint
Authors:  Céline Vallot and Claire Rougeulle, date: 09/05/2016, view: 7212, Q&A: 0
We developed a FISH-based method to directly assess chromosome-wide transcriptional activity, thereby enabling the visualization of the actively transcribed fraction of a chromosome at the single-cell level. We applied this method to probe the ...
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