Yoichiro Iwakura Center for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science, Japan
1 protocol

Aoi Akitsu
  • Dana Farber Cancer Institute
Research focus
  • Immunology
  • 1 Author merit


Ph.D. Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, January 2014

Current position

Postdoctoral Fellow of Tokyo University of Science


  1. Martin, B. N., Wang, C., Zhang, C. J., Kang, Z., Gulen, M. F., Zepp, J. A., Zhao, J., Bian, G., Do, J. S., Min, B., Pavicic, P. G., Jr., El-Sanadi, C., Fox, P. L., Akitsu, A., Iwakura, Y., Sarkar, A., Wewers, M. D., Kaiser, W. J., Mocarski, E. S., Rothenberg, M. E., Hise, A. G., Dubyak, G. R., Ransohoff, R. M. and Li, X. (2016). T cell-intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis. Nat Immunol 17(5): 583-592.

  2. Akitsu, A., Ishigame, H., Kakuta, S., Chung, S. H., Ikeda, S., Shimizu, K., Kubo, S., Liu, Y., Umemura, M., Matsuzaki, G., Yoshikai, Y., Saijo, S. and Iwakura, Y. (2015). IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)Vgamma6(+)gammadelta T cells. Nat Commun 6: 7464.

  3. Akitsu, A., Kakuta, S., Saijo, S. and Iwakura, Y. (2014). Rag2-deficient IL-1 Receptor Antagonist-deficient Mice Are a Novel Colitis Model in Which Innate Lymphoid Cell-derived IL-17 Is Involved in the Pathogenesis. Exp Anim 63(2): 235-246.

  4. Ikeda, S., Saijo, S., Murayama, M. A., Shimizu, K., Akitsu, A. and Iwakura, Y. (2014). Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-beta-induced Foxp3 expression. J Immunol 192(4): 1449-1458.

  5. Shimura, E., Shibui, A., Narushima, S., Nambu, A., Yamaguchi, S., Akitsu, A., Leonard, W. J., Iwakura, Y., Matsumoto, K., Suto, H., Okumura, K., Sudo, K. and Nakae, S. (2014). Potential role of myeloid cell/eosinophil-derived IL-17 in LPS-induced endotoxin shock. Biochem Biophys Res Commun 453(1): 1-6.

  6. Saijo, S., Ikeda, S., Yamabe, K., Kakuta, S., Ishigame, H., Akitsu, A., Fujikado, N., Kusaka, T., Kubo, S., Chung, S. H., Komatsu, R., Miura, N., Adachi, Y., Ohno, N., Shibuya, K., Yamamoto, N., Kawakami, K., Yamasaki, S., Saito, T., Akira, S. and Iwakura, Y. (2010). Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity 32(5): 681-691.

  7. Ishigame, H., Kakuta, S., Nagai, T., Kadoki, M., Nambu, A., Komiyama, Y., Fujikado, N., Tanahashi, Y., Akitsu, A., Kotaki, H., Sudo, K., Nakae, S., Sasakawa, C. and Iwakura, Y. (2009). Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity 30(1): 108-119.

1 Protocol published
Isolation of Joint-infiltrating Cells
Authors:  Aoi Akitsu and Yoichiro Iwakura, date: 09/05/2016, view: 8884, Q&A: 0
Infiltration of leukocytes into joints is one of the main features of autoimmune inflammatory arthritis. Here, we describe the protocol for isolation of joint-infiltrating cells in mice. This protocol is useful to analyze cell surface antigens and ...
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