Efrat Oni-Biton Department of Neurobiology, the Weizmann Institute, Israel
1 protocol

Noa Sadeh the Weizmann Institute
1 protocol

Menahem Segal
  • Department of Neurobiology, the Weizmann Institute, Israel
  • 1 Author merit


PhD, Division of Biology, California Institute of Technology, 1972

Current position

Emeritus Professor, Department of Neurobiology, The Weizmann Institute

Publications (since 2014)

  1. Grigoryan, G. and Segal, M. (2016). Lasting Differential Effects on Plasticity Induced by Prenatal Stress in Dorsal and Ventral Hippocampus. Neural Plast 2016: 2540462.

  2. Penn, Y., Segal, M. and Moses, E. (2016). Network synchronization in hippocampal neurons. Proc Natl Acad Sci U S A 113(12): 3341-3346.

  3. Telias, M., Segal, M. and Ben-Yosef, D. (2016). Immature Responses to GABA in Fragile X Neurons Derived from Human Embryonic Stem Cells. Front Cell Neurosci 10: 121.

  4. Visochek, L., Grigoryan, G., Kalal, A., Milshtein-Parush, H., Gazit, N., Slutsky, I., Yeheskel, A., Shainberg, A., Castiel, A., Seger, R., Langelier, M. F., Dantzer, F., Pascal, J. M., Segal, M. and Cohen-Armon, M. (2016). A PARP1-ERK2 synergism is required for the induction of LTP. Sci Rep 6: 24950.

  5. Grigoryan, G. and Segal, M. (2016). Ryanodine-mediated conversion of STP to LTP is lacking in synaptopodin-deficient mice. Brain Struct Funct 221(4): 2393-2397.

  6. Korkotian, E., Botalova, A., Odegova, T. and Segal, M. (2015). Chronic exposure to alcohol alters network activity and morphology of cultured hippocampal neurons. Neurotoxicology 47: 62-71.

  7. Korkotian, E., Botalova, A., Odegova, T., Galishevskaya, E., Skryabina, E. and Segal, M. (2015). Complex effects of aqueous extract of Melampyrum pratense and of its flavonoids on activity of primary cultured hippocampal neurons. J Ethnopharmacol 163: 220-228.

  8. Bock, J., Wainstock, T., Braun, K. and Segal, M. (2015). Stress In Utero: Prenatal Programming of Brain Plasticity and Cognition. Biol Psychiatry 78(5): 315-326.

  9. Duc, D. K., Lee, C. Y., Parutto, P., Cohen, D., Segal, M., Rouach, N. and Holcman, D. (2015). Bursting reverberation as a multiscale neuronal network process, modeled by synaptic depression-facilitation. Plus One May 27;10(5):e0124694.

  10. Sharvit, A., Segal, M., Kehat, O., Stork, O. and Richter-Levin, G. (2015). Differential modulation of synaptic plasticity and local circuit activity in the dentate gyrus and CA1 regions of the rat hippocampus by corticosterone. Stress 18(3): 319-327.

  11. Maggio, N., Shavit Stein, E. and Segal, M. (2015). Ischemic LTP: NMDA-dependency and dorso/ventral distribution within the hippocampus. Hippocampus 25(11): 1465-1471.

  12. Stern, S., Segal, M. and Moses, E. (2015). Involvement of Potassium and Cation Channels in Hippocampal Abnormalities of Embryonic Ts65Dn and Tc1 Trisomic Mice. EBioMedicine 2(9): 1048-1062.

  13. Sadeh, N., Verbitsky, S., Dudai, Y. and Segal, M. (2015). Zeta Inhibitory Peptide, a Candidate Inhibitor of Protein Kinase Mzeta, Is Excitotoxic to Cultured Hippocampal Neurons. J Neurosci 35(36): 12404-12411.

  14. Telias, M., Kuznitsov-Yanovsky, L., Segal, M. and Ben-Yosef, D. (2015). Functional Deficiencies in Fragile X Neurons Derived from Human Embryonic Stem Cells. J Neurosci 35(46): 15295-15306.

  15. Segal, M. and Korkotian, E. (2015). Roles of Calcium Stores and Store-Operated Channels in Plasticity of Dendritic Spines. Neuroscientist.

  16. Grigoryan, G., Ardi, Z., Albrecht, A., Richter-Levin, G. and Segal, M. (2015). Juvenile stress alters LTP in ventral hippocampal slices: involvement of noradrenergic mechanisms. Behav Brain Res 278: 559-562.

  17. Segal, M. and Korkotian, E. (2014). Endoplasmic reticulum calcium stores in dendritic spines. Front Neuroanat 8: 64.

  18. Telias, M., Segal, M. and Ben-Yosef, D. (2014). Electrical maturation of neurons derived from human embryonic stem cells. F1000Res 3: 196.

  19. Korkotian, E., Frotscher, M. and Segal, M. (2014). Synaptopodin regulates spine plasticity: mediation by calcium stores. J Neurosci 34(35): 11641-11651.

  20. Segal, M. and Maggio, N. (2014). Stress modulation of synaptic plasticity in the hippocampus. In: Popoli, M., Diamond, D. and Sanacora, G. (eds). Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders. pp:137-150.

  21. Sala, C. and Segal, M. (2014). Dendritic spines: the locus of structural and functional plasticity. Physiol Rev 94(1): 141-188.

  22. Grigoryan, G., Biella, G., Albani, D., Forloni, G. and Segal, M. (2014). Stress impairs synaptic plasticity in triple-transgenic Alzheimer's disease mice: rescue by ryanodine. Neurodegener Dis 13(2-3): 135-138.

1 Protocol published
Acute Live/Dead Assay for the Analysis of Toxic Effects of Drugs on Cultured Neurons
Authors:  Noa Sadeh, Efrat Oni-Biton and Menahem Segal, date: 08/05/2016, view: 3080, Q&A: 0
The primary culture of central nervous system (CNS) neurons is a popular test system for a rapid, quantitative and reliable assessment of the effects of drugs on central neurons. Consequently, studies on the excitotoxicity of NMDA activation and on ...