Chris Tibbitt Karolinska Institutet
1 protocol

Jonathan M. Coquet
  • Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Sweden
Research focus
  • Immunology
  • 1 Author merit


Ph.D. at the Department of Microbiology and Immunology, University of Melbourne with Prof. Dale Godfrey, 2008

Current position

Assistant Professor (Project Leader) at the Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute (KI), Solna, Sweden  


  1. Coquet, J. M., Schuijs, M. J., Smyth, M. J., Deswarte, K., Beyaert, R., Braun, H., Boon, L., Karlsson Hedestam, G. B., Nutt, S. L., Hammad, H. and Lambrecht, B. N. (2015). Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites. Immunity 43(2): 318-330.
  2. Coquet, J. M., Rausch, L. and Borst, J. (2015). The importance of co-stimulation in the orchestration of T helper cell differentiation. Immunol Cell Biol 93(9): 780-788.
  3. Coquet, J. M., Ribot, J. C., Babala, N., Middendorp, S., van der Horst, G., Xiao, Y., Neves, J. F., Fonseca-Pereira, D., Jacobs, H., Pennington, D. J., Silva-Santos, B. and Borst, J. (2013). Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway. J Exp Med 210(4): 715-728.
  4. Coquet, J. M., Middendorp, S., van der Horst, G., Kind, J., Veraar, E. A., Xiao, Y., Jacobs, H. and Borst, J. (2013). The CD27 and CD70 costimulatory pathway inhibits effector function of T helper 17 cells and attenuates associated autoimmunity. Immunity 38(1): 53-65.
  5. Coquet, J. M., Skak, K., Davis, I. D., Smyth, M. J. and Godfrey, D. I. (2013). IL-21 Modulates Activation of NKT Cells in Patients with Stage IV Malignant Melanoma. Clin Transl Immunology 2(10): e6.
  6. Anto, J. M., Pinart, M., Akdis, M., Auffray, C., Bachert, C., Basagana, X., Carlsen, K. H., Guerra, S., von Hertzen, L., Illi, S., Kauffmann, F., Keil, T., Kiley, J. P., Koppelman, G. H., Lupinek, C., Martinez, F. D., Nawijn, M. C., Postma, D. S., Siroux, V., Smit, H. A., Sterk, P. J., Sunyer, J., Valenta, R., Valverde, S., Akdis, C. A., Annesi-Maesano, I., Ballester, F., Benet, M., Cambon-Thomsen, A., Chatzi, L., Coquet, J., Demoly, P., Gan, W., Garcia-Aymerich, J., Gimeno-Santos, E., Guihenneuc-Jouyaux, C., Haahtela, T., Heinrich, J., Herr, M., Hohmann, C., Jacquemin, B., Just, J., Kerkhof, M., Kogevinas, M., Kowalski, M. L., Lambrecht, B. N., Lau, S., Lodrup Carlsen, K. C., Maier, D., Momas, I., Noel, P., Oddie, S., Palkonen, S., Pin, I., Porta, D., Punturieri, A., Ranciere, F., Smith, R. A., Stanic, B., Stein, R. T., van de Veen, W., van Oosterhout, A. J., Varraso, R., Wickman, M., Wijmenga, C., Wright, J., Yaman, G., Zuberbier, T., Bousquet, J., Asthma, W. H. O. C. C. o. and Rhinitis (2012). Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: a Mechanisms of the Development of Allergy (MeDALL) seminar. J Allergy Clin Immunol 129(4): 943-954 e944.
  7. Zotos, D., Coquet, J. M., Zhang, Y., Light, A., D'Costa, K., Kallies, A., Corcoran, L. M., Godfrey, D. I., Toellner, K. M., Smyth, M. J., Nutt, S. L. and Tarlinton, D. M. (2010). IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med 207(2): 365-378.
  8. Sondergaard, H., Coquet, J. M., Uldrich, A. P., McLaughlin, N., Godfrey, D. I., Sivakumar, P. V., Skak, K. and Smyth, M. J. (2009). Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunity. J Immunol 183(11): 7326-7336.
  9. Coquet, J. M., Chakravarti, S., Kyparissoudis, K., McNab, F. W., Pitt, L. A., McKenzie, B. S., Berzins, S. P., Smyth, M. J. and Godfrey, D. I. (2008). Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population. Proc Natl Acad Sci U S A 105(32): 11287-11292.
  10. Coquet, J. M., Chakravarti, S., Smyth, M. J. and Godfrey, D. I. (2008). Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis. J Immunol 180(11): 7097-7101.
  11. Coquet, J. M., Kyparissoudis, K., Pellicci, D. G., Besra, G., Berzins, S. P., Smyth, M. J. and Godfrey, D. I. (2007). IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J Immunol 178(5): 2827-2834.
  12. Swann, J. B., Coquet, J. M., Smyth, M. J. and Godfrey, D. I. (2007). CD1-restricted T cells and tumor immunity. Curr Top Microbiol Immunol 314: 293-323.
  13. Crowe, N. Y., Coquet, J. M., Berzins, S. P., Kyparissoudis, K., Keating, R., Pellicci, D. G., Hayakawa, Y., Godfrey, D. I. and Smyth, M. J. (2005). Differential antitumor immunity mediated by NKT cell subsets in vivo. J Exp Med 202(9): 1279-1288.
  14. Pellicci, D. G., Hammond, K. J., Coquet, J., Kyparissoudis, K., Brooks, A. G., Kedzierska, K., Keating, R., Turner, S., Berzins, S., Smyth, M. J. and Godfrey, D. I. (2005). DX5/CD49b-positive T cells are not synonymous with CD1d-dependent NKT cells. J Immunol 175(7): 4416-4425.
1 Protocol published
Authors:  Chris Tibbitt and Jonathan M. Coquet, date: 07/20/2016, view: 10050, Q&A: 1
Asthma is a complex disease of the airways primarily mediated by T helper 2 cells and innate lymphoid type 2 cells (Licona et al.,2013). Mice do not develop spontaneous asthma and therefore models have been developed for the assessment of ...
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