Prerak Trivedi Immunology and Diabetes Unit, St. Vincent’s Institute of Medical Research, Australia
1 protocol

Stuart I. Mannering
  • Immunology and Diabetes Unit, St. Vincent’s Institute of Medical Research, Australia
Research focus
  • Immunology
  • 1 Author merit


Ph.D. in Immunology, University of Otago, New Zealand,1988

Current position

A/Prof and Head, Human T-cell laboratory, St. Vincent’s Institute of Medical Research, Fitzroy, Australia

Publications (since 2012)

  1. Delong, T., Wiles, T. A., Baker, R. L., Bradley, B., Barbour, G., Reisdorph, R., Armstrong, M., Powell, R. L., Reisdorph, N., Kumar, N., Elso, C. M., DeNicola, M., Bottino, R., Powers, A. C., Harlan, D. M., Kent, S. C., Mannering, S. I. and Haskins, K. (2016). Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion. Science 351(6274): 711-714.
  2. Mannering, S. I., Pathiraja, V. and Kay, T. W. (2016). The case for an autoimmune aetiology of type 1 diabetes. Clin Exp Immunol 183(1): 8-15.
  3. Zhao, Y., Scott, N. A., Quah, H. S., Krishnamurthy, B., Bond, F., Loudovaris, T., Mannering, S. I., Kay, T. W. and Thomas, H. E. (2015). Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate. Eur J Immunol 45(9): 2494-2503.
  4. Jenkins, M. R., Rudd-Schmidt, J. A., Lopez, J. A., Ramsbottom, K. M., Mannering, S. I., Andrews, D. M., Voskoboinik, I. and Trapani, J. A. (2015). Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time. J Exp Med 212(3): 307-317.
  5. Pathiraja, V., Kuehlich, J. P., Campbell, P. D., Krishnamurthy, B., Loudovaris, T., Coates, P. T., Brodnicki, T. C., O'Connell, P. J., Kedzierska, K., Rodda, C., Bergman, P., Hill, E., Purcell, A. W., Dudek, N. L., Thomas, H. E., Kay, T. W. and Mannering, S. I. (2015). Proinsulin-specific, HLA-DQ8, and HLA-DQ8-transdimer-restricted CD4+ T cells infiltrate islets in type 1 diabetes. Diabetes 64(1): 172-182.
  6. Wang, N., Elso, C. M., Mackin, L., Mannering, S. I., Strugnell, R. A., Wijburg, O. L. and Brodnicki, T. C. (2014). Congenic mice reveal genetic epistasis and overlapping disease loci for autoimmune diabetes and listeriosis. Immunogenetics 66(7-8): 501-506.
  7. Lopez, J. A., Jenkins, M. R., Rudd-Schmidt, J. A., Brennan, A. J., Danne, J. C., Mannering, S. I., Trapani, J. A. and Voskoboinik, I. (2013). Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse. J Immunol 191(5): 2328-2334.
  8. Prickett, S. R., Voskamp, A. L., Phan, T., Dacumos-Hill, A., Mannering, S. I., Rolland, J. M. and O'Hehir, R. E. (2013). Ara h 1 CD4+ T cell epitope-based peptides: candidates for a peanut allergy therapeutic. Clin Exp Allergy 43(6): 684-697.
  9. Graham, K. L., Sutherland, R. M., Mannering, S. I., Zhao, Y., Chee, J., Krishnamurthy, B., Thomas, H. E., Lew, A. M. and Kay, T. W. (2012). Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease. Rev Diabet Stud 9(4): 148-168.
  10. Broughton, S. E., Petersen, J., Theodossis, A., Scally, S. W., Loh, K. L., Thompson, A., van Bergen, J., Kooy-Winkelaar, Y., Henderson, K. N., Beddoe, T., Tye-Din, J. A., Mannering, S. I., Purcell, A. W., McCluskey, J., Anderson, R. P., Koning, F., Reid, H. H. and Rossjohn, J. (2012). Biased T cell receptor usage directed against human leukocyte antigen DQ8-restricted gliadin peptides is associated with celiac disease. Immunity 37(4): 611-621.
  11. Necula, A., Chand, R., Albatat, B. and Mannering, S. I. (2012). Extraction of tissue antigens for functional assays. J Vis Exp(67).
  12. Joffe, M., Necula, A. S., Chand, R., McWhinney, B. C., Krishnamurthy, B., Loudovaris, T., Goodman, D., Thomas, H. E., Kay, T. W. and Mannering, S. I. (2012). Residual methylprednisolone suppresses human T-cell responses to spleen, but not islet, extracts from deceased organ donors. Int Immunol 24(7): 447-453.
1 Protocol published
Authors:  Prerak Trivedi and Stuart I. Mannering, date: 06/20/2016, view: 7115, Q&A: 0
Human antigen-specific CD8+ T-cell clones are valuable tools for dissecting CD8+ T-cell responses against antigens derived from infectious agents, cancer and self antigens. Here we describe a protocol for isolating human ...
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