Alexander Vesprey Department of Orthopaedics, Alpert Medical School and Rhode Island Hospital, Brown University, USA
1 protocol

Wentian Yang
  • Department of Orthopaedics, Alpert Medical School and Rhode Island Hospital, Brown University, USA
Research focus
  • Stem cell
  • 1 Author merit


Ph.D. in Molecular Biology, School of Medicine, Sichuan University, P.R. China.

Current position

Associate professor of Orthopaedics and Medicine, Department of Orthopaedics, Alpert Medical School, Brown University


  1. Liu, X., Zheng, H., Li, X., Wang, S., Meyerson, H. J., Yang, W., Neel, B. G. and Qu, C. K. (2016). Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies. Proc Natl Acad Sci U S A 113(4): 984-989.
  2. Zhou, Y., Mohan, A., Moore, D. C., Lin, L., Zhou, F. L., Cao, J., Wu, Q., Qin, Y. X., Reginato, A. M., Ehrlich, M. G. and Yang, W. (2015). SHP2 regulates osteoclastogenesis by promoting preosteoclast fusion. FASEB J 29(5): 1635-1645.
  3. Bowen, M. E., Ayturk, U. M., Kurek, K. C., Yang, W. and Warman, M. L. (2014). SHP2 regulates chondrocyte terminal differentiation, growth plate architecture and skeletal cell fates. PLoS Genet 10(5): e1004364.
  4. Yang, W. and Neel, B. G. (2013). From an orphan disease to a generalized molecular mechanism: PTPN11 loss-of-function mutations in the pathogenesis of metachondromatosis. Rare Dis 1: e26657.
  5. Yang, W., Wang, J., Moore, D. C., Liang, H., Dooner, M., Wu, Q., Terek, R., Chen, Q., Ehrlich, M. G., Quesenberry, P. J. and Neel, B. G. (2013). Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling. Nature 499(7459): 491-495.
  6. Yang, W., Klaman, L. D., Chen, B., Araki, T., Harada, H., Thomas, S. M., George, E. L. and Neel, B. G. (2006). An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival. Dev Cell 10(3): 317-327.
1 Protocol published
Pit Assay to Measure the Bone Resorptive Activity of Bone Marrow-derived Osteoclasts
Authors:  Alexander Vesprey and Wentian Yang, date: 06/20/2016, view: 11602, Q&A: 0
Although it is possible to use a tartrate-resistant acid phosphatase (TRAP) stain to assist in identifying osteoclasts, a separate method is needed to determine the bone resorption activity of osteoclasts. Since osteoclasts leave “pits” after bone ...
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