Andrew Tee Institute of Cancer and Genetics, Cardiff University, UK
1 protocol

Kayleigh Margaret Dodd
  • Institute of Cancer and Genetics, Cardiff University, UK
  • 1 Author merit

Education

Ph.D., School of Medicine, Cardiff University, UK, 2011

Current position

Post-doctoral research fellow, School of Medicine, Cardiff University, 2011

Publications

  1. Dodd, K. M. and Dunlop, E. A. (2016). Tuberous sclerosis-A model for tumour growth. Semin Cell Dev Biol 52: 3-11. [Epub ahead of print]. (K.M. Dodd corresponding author).
  2. Dodd, K. M. and Tee, A. R. (2015). STAT3 and mTOR: co-operating to drive HIF and angiogenesis. Oncoscience 2(11): 913-914.
  3. Thomas, L. E., Winston, J., Rad, E., Mort, M., Dodd, K. M., Tee, A. R., McDyer, F., Moore, S., Cooper, D. N. and Upadhyaya, M. (2015). Evaluation of copy number variation and gene expression in neurofibromatosis type-1-associated malignant peripheral nerve sheath tumours. Hum Genomics 9: 3.
  4. Rad, E., Dodd, K. M., Thomas, L. E., Upadhyaya, M. and Tee, A. R. (2015). STAT3 and HIF-1α signalling drives oncogenic cellular phenotypes in malignant peripheral nerve sheath tumours. Mol Cancer Res 13(7): 1149-1160.
  5. Dodd, K. M., Yang, J., Shen, M. H., Sampson, J. R. and Tee, A. R. (2015). mTORC1 drives HIF-1alpha and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3. Oncogene 34(17): 2239-2250.
  6. Zhang, J., Kim, J., Alexander, A., Cai, S., Tripathi, D. N., Dere, R., Tee, A. R., Tait-Mulder, J., Di Nardo, A., Han, J. M., Kwiatkowski, E., Dunlop, E. A., Dodd, K. M., Folkerth, R. D., Faust, P. L., Kastan, M. B., Sahin, M. and Walker, C. L. (2013). A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nat Cell Biol 15(10): 1186-1196.
  7. Dodd, K. M. and Tee, A. R. (2012). Leucine and mTORC1: a complex relationship. Am J Physiol Endocrinol Metab 302(11): E1329-1342.
  8. Dunlop, E. A., Dodd, K. M., Land, S. C., Davies, P. A., Martins, N., Stuart, H., McKee, S., Kingswood, C., Saggar, A., Corderio, I., Medeira, A. M., Kingston, H., Sampson, J. R., Davies, D. M. and Tee, A. R. (2011). Determining the pathogenicity of patient-derived TSC2 mutations by functional characterization and clinical evidence. Eur J Hum Genet 19(7): 789-795.
  9. Dunlop, E. A., Dodd, K. M., Seymour, L. A. and Tee, A. R. (2009). Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition. Cell Signal 21(7): 1073-1084.
1 Protocol published
In vitro mTORC1 Kinase Assay for Mammalian Cells Protocol
Authors:  Kayleigh Margaret Dodd and Andrew Robert Tee, date: 06/05/2016, view: 5134, Q&A: 0
Historically, mechanistic target of rapamycin (mTOR) was purified from mammalian cells using mild nonionic detergents such as NP-40 and or Triton-X100 that resulted in dissociation of core regulatory components essential for its native kinase ...
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