Alfred Robison Department of Physiology and Neuroscience Program, Michigan State University, USA
2 protocols

Andrew Eagle Michigan State University
2 protocols

Michelle Mazei-Robison
  • Department of Physiology and Neuroscience Program, Michigan State University, USA
Research focus
  • Neuroscience
  • 1 Author merit


Ph.D. in Pharmacology, Vanderbilt University, USA, 2005

Current position

Assistant professor of Physiology and Neuroscience, Michigan State University, East Lansing, USA

Publications (since 2005)

  1. Iniguez, S. D., Riggs, L. M., Nieto, S. J., Wright, K. N., Zamora, N. N., Cruz, B., Zavala, A. R., Robison, A. J. and Mazei-Robison, M. S. (2015). Fluoxetine exposure during adolescence increases preference for cocaine in adulthood. Sci Rep 5: 15009.
  2. Eagle, A. L., Gajewski, P. A., Yang, M., Kechner, M. E., Al Masraf, B. S., Kennedy, P. J., Wang, H., Mazei-Robison, M. S. and Robison, A. J. (2015). Experience-Dependent Induction of Hippocampal DeltaFosB Controls Learning. J Neurosci 35(40): 13773-13783.
  3. Vialou, V., Thibault, M., Kaska, S., Cooper, S., Gajewski, P., Eagle, A., Mazei-Robison, M., Nestler, E. J. and Robison, A. J. (2015). Differential induction of FosB isoforms throughout the brain by fluoxetine and chronic stress. Neuropharmacology 99: 28-37.
  4. Dias, C., Dietz, D., Mazei-Robison, M., Sun, H., Damez-Werno, D., Ferguson, D., Wilkinson, M., Magida, J., Gao, V., Neve, R. and Nestler, E. J. (2015). Dishevelled-2 regulates cocaine-induced structural plasticity and Rac1 activity in the nucleus accumbens. Neurosci Lett 598: 23-28.
  5. Koo, J. W., Mazei-Robison, M. S., LaPlant, Q., Egervari, G., Braunscheidel, K. M., Adank, D. N., Ferguson, D., Feng, J., Sun, H., Scobie, K. N., Damez-Werno, D. M., Ribeiro, E., Pena, C. J., Walker, D., Bagot, R. C., Cahill, M. E., Anderson, S. A., Labonte, B., Hodes, G. E., Browne, H., Chadwick, B., Robison, A. J., Vialou, V. F., Dias, C., Lorsch, Z., Mouzon, E., Lobo, M. K., Dietz, D. M., Russo, S. J., Neve, R. L., Hurd, Y. L. and Nestler, E. J. (2015). Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area. Nat Neurosci 18(3): 415-422.
  6. Dias, C., Feng, J., Sun, H., Shao, N. Y., Mazei-Robison, M. S., Damez-Werno, D., Scobie, K., Bagot, R., LaBonte, B., Ribeiro, E., Liu, X., Kennedy, P., Vialou, V., Ferguson, D., Pena, C., Calipari, E. S., Koo, J. W., Mouzon, E., Ghose, S., Tamminga, C., Neve, R., Shen, L. and Nestler, E. J. (2014). beta-catenin mediates stress resilience through Dicer1/microRNA regulation. Nature 516(7529): 51-55.
  7. Heller, E. A., Cates, H. M., Pena, C. J., Sun, H., Shao, N., Feng, J., Golden, S. A., Herman, J. P., Walsh, J. J., Mazei-Robison, M., Ferguson, D., Knight, S., Gerber, M. A., Nievera, C., Han, M. H., Russo, S. J., Tamminga, C. S., Neve, R. L., Shen, L., Zhang, H. S., Zhang, F. and Nestler, E. J. (2014). Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors. Nat Neurosci 17(12): 1720-1727.
  8. Heller, E. A., Kaska, S., Fallon, B., Ferguson, D., Kennedy, P. J., Neve, R. L., Nestler, E. J. and Mazei-Robison, M. S. (2015). Morphine and cocaine increase serum- and glucocorticoid-inducible kinase 1 activity in the ventral tegmental area. J Neurochem 132(2): 243-253.
  9. Mazei-Robison, M. S., Appasani, R., Edwards, S., Wee, S., Taylor, S. R., Picciotto, M. R., Koob, G. F. and Nestler, E. J. (2014). Self-administration of ethanol, cocaine, or nicotine does not decrease the soma size of ventral tegmental area dopamine neurons. PLoS One 9(4): e95962.
  10. Vialou, V., Bagot, R. C., Cahill, M. E., Ferguson, D., Robison, A. J., Dietz, D. M., Fallon, B., Mazei-Robison, M., Ku, S. M., Harrigan, E., Winstanley, C. A., Joshi, T., Feng, J., Berton, O. and Nestler, E. J. (2014). Prefrontal cortical circuit for depression- and anxiety-related behaviors mediated by cholecystokinin: role of DeltaFosB. J Neurosci 34(11): 3878-3887.
  11. Der-Avakian, A., Mazei-Robison, M. S., Kesby, J. P., Nestler, E. J. and Markou, A. (2014). Enduring deficits in brain reward function after chronic social defeat in rats: susceptibility, resilience, and antidepressant response. Biol Psychiatry 76(7): 542-549.
  12. Walsh, J. J., Friedman, A. K., Sun, H., Heller, E. A., Ku, S. M., Juarez, B., Burnham, V. L., Mazei-Robison, M. S., Ferguson, D., Golden, S. A., Koo, J. W., Chaudhury, D., Christoffel, D. J., Pomeranz, L., Friedman, J. M., Russo, S. J., Nestler, E. J. and Han, M. H. (2014). Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway. Nat Neurosci 17(1): 27-29.
  13. Robison, A. J., Vialou, V., Sun, H. S., Labonte, B., Golden, S. A., Dias, C., Turecki, G., Tamminga, C., Russo, S., Mazei-Robison, M. and Nestler, E. J. (2014). Fluoxetine epigenetically alters the CaMKIIalpha promoter in nucleus accumbens to regulate DeltaFosB binding and antidepressant effects. Neuropsychopharmacology 39(5): 1178-1186.
  14. Robison, A. J., Vialou, V., Mazei-Robison, M., Feng, J., Kourrich, S., Collins, M., Wee, S., Koob, G., Turecki, G., Neve, R., Thomas, M. and Nestler, E. J. (2013). Behavioral and structural responses to chronic cocaine require a feedforward loop involving DeltaFosB and calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell. J Neurosci 33(10): 4295-4307.
  15. Chaudhury, D., Walsh, J. J., Friedman, A. K., Juarez, B., Ku, S. M., Koo, J. W., Ferguson, D., Tsai, H. C., Pomeranz, L., Christoffel, D. J., Nectow, A. R., Ekstrand, M., Domingos, A., Mazei-Robison, M. S., Mouzon, E., Lobo, M. K., Neve, R. L., Friedman, J. M., Russo, S. J., Deisseroth, K., Nestler, E. J. and Han, M. H. (2013). Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature 493(7433): 532-536.
  16. Moritz, A. E., Foster, J. D., Gorentla, B. K., Mazei-Robison, M. S., Yang, J. W., Sitte, H. H., Blakely, R. D. and Vaughan, R. A. (2013). Phosphorylation of dopamine transporter serine 7 modulates cocaine analog binding. J Biol Chem 288(1): 20-32.
  17. Koo, J. W., Mazei-Robison, M. S., Chaudhury, D., Juarez, B., LaPlant, Q., Ferguson, D., Feng, J., Sun, H., Scobie, K. N., Damez-Werno, D., Crumiller, M., Ohnishi, Y. N., Ohnishi, Y. H., Mouzon, E., Dietz, D. M., Lobo, M. K., Neve, R. L., Russo, S. J., Han, M. H. and Nestler, E. J. (2012). BDNF is a negative modulator of morphine action. Science 338(6103): 124-128.
  18. Vialou, V., Feng, J., Robison, A. J., Ku, S. M., Ferguson, D., Scobie, K. N., Mazei-Robison, M. S., Mouzon, E. and Nestler, E. J. (2012). Serum response factor and cAMP response element binding protein are both required for cocaine induction of DeltaFosB. J Neurosci 32(22): 7577-7584.
  19. Dietz, D. M., Sun, H., Lobo, M. K., Cahill, M. E., Chadwick, B., Gao, V., Koo, J. W., Mazei-Robison, M. S., Dias, C., Maze, I., Damez-Werno, D., Dietz, K. C., Scobie, K. N., Ferguson, D., Christoffel, D., Ohnishi, Y., Hodes, G. E., Zheng, Y., Neve, R. L., Hahn, K. M., Russo, S. J. and Nestler, E. J. (2012). Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons. Nat Neurosci 15(6): 891-896.
  20. Sakrikar, D., Mazei-Robison, M. S., Mergy, M. A., Richtand, N. W., Han, Q., Hamilton, P. J., Bowton, E., Galli, A., Veenstra-Vanderweele, J., Gill, M. and Blakely, R. D. (2012). Attention deficit/hyperactivity disorder-derived coding variation in the dopamine transporter disrupts microdomain targeting and trafficking regulation. J Neurosci 32(16): 5385-5397.
  21. Mazei-Robison, M. S., Koo, J. W., Friedman, A. K., Lansink, C. S., Robison, A. J., Vinish, M., Krishnan, V., Kim, S., Siuta, M. A., Galli, A., Niswender, K. D., Appasani, R., Horvath, M. C., Neve, R. L., Worley, P. F., Snyder, S. H., Hurd, Y. L., Cheer, J. F., Han, M. H., Russo, S. J. and Nestler, E. J. (2011). Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons. Neuron 72(6): 977-990.
  22. Wilkinson, M. B., Dias, C., Magida, J., Mazei-Robison, M., Lobo, M., Kennedy, P., Dietz, D., Covington, H., 3rd, Russo, S., Neve, R., Ghose, S., Tamminga, C. and Nestler, E. J. (2011). A novel role of the WNT-dishevelled-GSK3beta signaling cascade in the mouse nucleus accumbens in a social defeat model of depression. J Neurosci 31(25): 9084-9092.
  23. Liu, Y., Aragona, B. J., Young, K. A., Dietz, D. M., Kabbaj, M., Mazei-Robison, M., Nestler, E. J. and Wang, Z. (2010). Nucleus accumbens dopamine mediates amphetamine-induced impairment of social bonding in a monogamous rodent species. Proc Natl Acad Sci U S A 107(3): 1217-1222.
  24. English, B. A., Hahn, M. K., Gizer, I. R., Mazei-Robison, M., Steele, A., Kurnik, D. M., Stein, M. A., Waldman, I. D. and Blakely, R. D. (2009). Choline transporter gene variation is associated with attention-deficit hyperactivity disorder. J Neurodev Disord 1(4): 252-263.
  25. Russo, S. J., Wilkinson, M. B., Mazei-Robison, M. S., Dietz, D. M., Maze, I., Krishnan, V., Renthal, W., Graham, A., Birnbaum, S. G., Green, T. A., Robison, B., Lesselyong, A., Perrotti, L. I., Bolanos, C. A., Kumar, A., Clark, M. S., Neumaier, J. F., Neve, R. L., Bhakar, A. L., Barker, P. A. and Nestler, E. J. (2009). Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward. J Neurosci 29(11): 3529-3537.
  26. Krishnan, V., Han, M. H., Mazei-Robison, M., Iniguez, S. D., Ables, J. L., Vialou, V., Berton, O., Ghose, S., Covington, H. E., 3rd, Wiley, M. D., Henderson, R. P., Neve, R. L., Eisch, A. J., Tamminga, C. A., Russo, S. J., Bolanos, C. A. and Nestler, E. J. (2008). AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli. Biol Psychiatry 64(8): 691-700.
  27. Krishnan, V., Graham, A., Mazei-Robison, M. S., Lagace, D. C., Kim, K. S., Birnbaum, S., Eisch, A. J., Han, P. L., Storm, D. R., Zachariou, V. and Nestler, E. J. (2008). Calcium-sensitive adenylyl cyclases in depression and anxiety: behavioral and biochemical consequences of isoform targeting. Biol Psychiatry 64(4): 336-343.
  28. Mazei-Robison, M. S., Bowton, E., Holy, M., Schmudermaier, M., Freissmuth, M., Sitte, H. H., Galli, A. and Blakely, R. D. (2008). Anomalous dopamine release associated with a human dopamine transporter coding variant. J Neurosci 28(28): 7040-7046.
  29. Haik, K. L., Shear, D. A., Hargrove, C., Patton, J., Mazei-Robison, M., Sandstrom, M. I. and Dunbar, G. L. (2008). 7-nitroindazole attenuates 6-hydroxydopamine-induced spatial learning deficits and dopamine neuron loss in a presymptomatic animal model of Parkinson's disease. Exp Clin Psychopharmacol 16(2): 178-189.
  30. Hahn, M. K., Blackford, J. U., Haman, K., Mazei-Robison, M., English, B. A., Prasad, H. C., Steele, A., Hazelwood, L., Fentress, H. M., Myers, R., Blakely, R. D., Sanders-Bush, E. and Shelton, R. (2008). Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression. Genes Brain Behav 7(4): 487-495.
  31. Kim, C. H., Hahn, M. K., Joung, Y., Anderson, S. L., Steele, A. H., Mazei-Robinson, M. S., Gizer, I., Teicher, M. H., Cohen, B. M., Robertson, D., Waldman, I. D., Blakely, R. D. and Kim, K. S. (2006). A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder. Proc Natl Acad Sci U S A 103(50): 19164-19169.
  32. Mazei-Robison, M. S. and Blakely, R. D. (2005). Expression studies of naturally occurring human dopamine transporter variants identifies a novel state of transporter inactivation associated with Val382Ala. Neuropharmacology 49(6): 737-749.
  33. Mazei-Robison, M. S., Couch, R. S., Shelton, R. C., Stein, M. A. and Blakely, R. D. (2005). Sequence variation in the human dopamine transporter gene in children with attention deficit hyperactivity disorder. Neuropharmacology 49(6): 724-736.
  34. Hahn, M. K., Mazei-Robison, M. S. and Blakely, R. D. (2005). Single nucleotide polymorphisms in the human norepinephrine transporter gene affect expression, trafficking, antidepressant interaction, and protein kinase C regulation. Mol Pharmacol 68(2): 457-466.
1 Protocol published
Sucrose Preference Test to Measure Stress-induced Anhedonia
Authors:  Andrew L. Eagle, Michelle Mazei-Robison and Alfred J. Robison, date: 06/05/2016, view: 27421, Q&A: 2
The 2-bottle choice procedure for assessing sucrose preference is a useful test to investigate anhedonia (i.e., inability to feel pleasure) in laboratory rodents, particularly in stress-based models of depression. The 2-bottle choice ...
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