Smitha Infante Dept Biochem. & Mol. Biol., University of Texas Medical Branch, USA
1 protocol

Harriet Rea Dept Neurology, Baylor College of Medicine, USA
1 protocol

J. Regino Perez-Polo
  • Dept Biochem. & Mol. Biol., University of Texas Medical Branch, USA
Research focus
  • Neuroscience
  • 1 Author merit


Ph.D. in Biophysics, Stanford University, Stanford, USA

Current position

I.H. Kempner Professor,
Dept of Biochemistry & Molecular Biology
Sealy Center on Aging
George P. and Cynthia Woods Mitchell Center for Neurodegenerative Disease Res.
Center for Brain and Spinal Cord Injury Research
Sealy Center for Molecular Medicine
Member Sealy Center for Structural Biology and Molecular Biophysics
Institute for Translational Science
Institute for Medical Humanities
The University of Texas Medical Branch

Publications (since 2013)

  1. Perez-Polo, J. R., Rea, H. C., Johnson, K. M., Parsley, M. A., Unabia, G. C., Xu, G. Y., Prough, D., DeWitt, D. S., Spratt, H. and Hulsebosch, C. E. (2015). A rodent model of mild traumatic brain blast injury. J Neurosci Res 93(4): 549-561.
  2. Kaur, N., Dhiman, M., Perez-Polo, J. R. and Mantha, A. K. (2015). Ginkgolide B revamps neuroprotective role of apurinic/apyrimidinic endonuclease 1 and mitochondrial oxidative phosphorylation against Abeta25-35 -induced neurotoxicity in human neuroblastoma cells. J Neurosci Res 93(6): 938-947.
  3. Carver, A. R., Tamayo, E., Perez-Polo, J. R., Saade, G. R., Hankins, G. D. and Costantine, M. M. (2014). The effect of maternal pravastatin therapy on adverse sensorimotor outcomes of the offspring in a murine model of preeclampsia. Int J Dev Neurosci 33: 33-40.
  4. Birnbaum, Y., Nanhwan, M. K., Ling, S., Perez-Polo, J. R., Ye, Y. and Bajaj, M. (2014). PTEN upregulation may explain the development of insulin resistance and type 2 diabetes with high dose statins. Cardiovasc Drugs Ther 28(5): 447-457.
  5. Ye, Y., Qian, J., Castillo, A. C., Ling, S., Ye, H., Perez-Polo, J. R., Bajaj, M. and Birnbaum, Y. (2013). Phosphodiesterase-3 inhibition augments the myocardial infarct size-limiting effects of exenatide in mice with type 2 diabetes. Am J Physiol Heart Circ Physiol 304(1): H131-141.
  6. Perez-Polo, J. R., Rea, H. C., Johnson, K. M., Parsley, M. A., Unabia, G. C., Xu, G., Infante, S. K., Dewitt, D. S. and Hulsebosch, C. E. (2013). Inflammatory consequences in a rodent model of mild traumatic brain injury. J Neurotrauma 30(9): 727-740.
  7. Dewitt, D. S., Perez-Polo, R., Hulsebosch, C. E., Dash, P. K. and Robertson, C. S. (2013). Challenges in the development of rodent models of mild traumatic brain injury. J Neurotrauma 30(9): 688-701.
  8. Ye, H., Ling, S., Castillo, A. C., Thomas, B., Long, B., Qian, J., Perez-Polo, J. R., Ye, Y., Chen, X. and Birnbaum, Y. (2013). Nebivolol induces distinct changes in profibrosis microRNA expression compared with atenolol, in salt-sensitive hypertensive rats. Hypertension 61(5): 1008-1013.
  9. Infante, S. K., Oberhauser, A. F. and Perez-Polo, J. R. (2013). Bax phosphorylation association with nucleus and oligomerization after neonatal hypoxia-ischemia. J Neurosci Res 91(9): 1152-1164.
  10. Infante, S. K., Rea, H. C. and Perez-Polo, J. R. (2013). Transgenerational effects of neonatal hypoxia-ischemia in progeny. Int J Dev Neurosci 31(6): 398-405.
  11. Vandame, D., Ulmann, L., Teigell, M., Prieto-Cappellini, M., Vignon, J., Privat, A., Perez-Polo, R., Nesic, O. and Hirbec, H. (2013). Development of NMDAR antagonists with reduced neurotoxic side effects: a study on GK11. PLoS One 8(11): e81004.
  12. Mantha, A. K., Dhiman, M., Taglialatela, G., Perez-Polo, R. J. and Mitra, S. (2012). Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction. J Neurosci Res 90(6): 1230-1239.
  13. Birnbaum, Y., Castillo, A. C., Qian, J., Ling, S., Ye, H., Perez-Polo, J. R., Bajaj, M. and Ye, Y. (2012). Phosphodiesterase III inhibition increases cAMP levels and augments the infarct size limiting effect of a DPP-4 inhibitor in mice with type-2 diabetes mellitus. Cardiovasc Drugs Ther 26(6): 445-456.
1 Protocol published
Authors:  J. Regino Perez-Polo, Harriet C. Rea and Smitha K. Infante, date: 11/20/2015, view: 7301, Q&A: 0
Neonatal hypoxia-ischemia (HI) affects 60% of low birth weight infants and up to 40% of preterm births. Cell death and brain injury after HI have been shown to cause long-lasting neurological deficits. Two motor coordination tests on rats that had ...
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