Lynn Hlatky Center of Cancer Systems Biology, Tufts University School of Medicine, USA
1 protocol

Philip Hahnfeldt Center of Cancer Systems Biology, Tufts University School of Medicine, USA
1 protocol

Sebastien Benzekry INRIA Bordeaux Sud-Ouest MONC, France
1 protocol

Afshin Beheshti
  • Molecular Oncology Research Institute, Tufts Medical Center, Tufts Cancer Center, Tufts University School of Medicine, USA
Research focus
  • Cancer biology
  • 1 Author merit


Ph.D. in Biophysics, Florida State University, Tallahassee, FL, 2002

Current position

Assistant Professor/Research Associate, Tufts University School of Medicine/Tufts Medical Center, Boston, MA (2014-present)


  1. Beheshti, A., Benzekry, S., McDonald, J. T., Ma, L., Peluso, M., Hahnfeldt, P. and Hlatky, L. (2015). Host age is a systemic regulator of gene expression impacting cancer progression. Cancer Res 75(6): 1134-1143.
  2. Wage, J., Ma, L., Peluso, M., Lamont, C., Evens, A. M., Hahnfeldt, P., Hlatky, L. and Beheshti, A. (2015). Proton irradiation impacts age-driven modulations of cancer progression influenced by immune system transcriptome modifications from splenic tissue. J Radiat Res 56(5): 792-803.
  3. Beheshti, A., Wage, J., McDonald, J. T., Lamont, C., Peluso, M., Hahnfeldt, P. and Hlatky, L. (2015). Tumor-host signaling interaction reveals a systemic, age-dependent splenic immune influence on tumor development. Oncotarget. In press.
  4. Suresh Kumar, M. A., Peluso, M., Chaudhary, P., Dhawan, J., Beheshti, A., Manickam, K., Thapar, U., Pena, L., Natarajan, M., Hlatky, L., Demple, B. and Naidu, M. (2015). Fractionated Radiation Exposure of Rat Spinal Cords Leads to Latent Neuro-Inflammation in Brain, Cognitive Deficits, and Alterations in Apurinic Endonuclease 1. PLoS One 10(7): e0133016.
  5. Beheshti, A., Peluso, M., Lamont, C., Hahnfeldt, P. and Hlatky, L. (2014). Proton irradiation augments the suppression of tumor progression observed with advanced age. Radiat Res 181(3): 272-283.
  6. Benzekry, S., Lamont, C., Beheshti, A., Tracz, A., Ebos, J. M., Hlatky, L. and Hahnfeldt, P. (2014). Classical mathematical models for description and prediction of experimental tumor growth. PLoS Comput Biol 10(8): e1003800.
  7. Almog, N., Briggs, C., Beheshti, A., Ma, L., Wilkie, K. P., Rietman, E. and Hlatky, L. (2013). Transcriptional changes induced by the tumor dormancy-associated microRNA-190. Transcription 4(4): 177-191.
  8. Beheshti, A., Pinzer, B. R., McDonald, J. T., Stampanoni, M. and Hlatky, L. (2013). Early tumor development captured through nondestructive, high resolution differential phase contrast X-ray imaging. Radiat Res 180(5): 448-454.
  9. Beheshti, A., Sachs, R. K., Peluso, M., Rietman, E., Hahnfeldt, P. and Hlatky, L. (2013). Age and space irradiation modulate tumor progression: implications for carcinogenesis risk. Radiat Res 179(2): 208-220.
  10. Almog, N., Ma, L., Schwager, C., Brinkmann, B. G., Beheshti, A., Vajkoczy, P., Folkman, J., Hlatky, L. and Abdollahi, A. (2012). Consensus micro RNAs governing the switch of dormant tumors to the fast-growing angiogenic phenotype. PLoS One 7(8): e44001.
  11. Domhan, S., Ma, L., Tai, A., Anaya, Z., Beheshti, A., Zeier, M., Hlatky, L. and Abdollahi, A. (2011). Intercellular communication by exchange of cytoplasmic material via tunneling nano-tube like structures in primary human renal epithelial cells. PLoS One 6(6): e21283.
  12. Enderling, H., Anderson, A. R., Chaplain, M. A., Beheshti, A., Hlatky, L. and Hahnfeldt, P. (2009). Paradoxical dependencies of tumor dormancy and progression on basic cell kinetics. Cancer Res 69(22): 8814-8821.
1 Protocol published
Capturing the Driving Role of Tumor-host Crosstalk in a Dynamical Model of Tumor Growth
Authors:  Sebastien Benzekry, Afshin Beheshti, Philip Hahnfeldt and Lynn Hlatky, date: 11/05/2015, view: 7545, Q&A: 0
In 1999, Hahnfeldt et al. proposed a mathematical model for tumor growth as dictated by reciprocal communications between tumor and its associated vasculature, introducing the idea that a tumor is supported by a dynamic, rather than a ...
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