Ming Li Immunology Program, Memorial Sloan Kettering Cancer Center, USA
3 protocols
Benoit Chassaing Georgia State University
14 protocols

Chris Tibbitt Karolinska Institutet
3 protocols

Filipa Vaz University of Glasgow
6 protocols

Francesco Borriello Boston Children's Hospital
1 protocol

Ruth A. Franklin
  • Yale University
Research focus
  • Immunology
  • 1 Author merit


Ph.D. in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY, 2014

Current position

Postdoctoral Research Fellow, Department of Immunobiology, Yale School of Medicine, New Haven, CT


  1. Dadi, S., Chhangawala, S., Whitlock, B. M., Franklin, R. A., Luo, C. T., Oh, S. A., Toure, A., Pritykin, Y., Huse, M., Leslie, C. S. and Li, M. O. (2016). Cancer immunosurveillance by tissue-resident innate lymphoid cells and innate-like T cells. Cell 164(3): 365-377.
  2. Franklin, R. A. and Li, M. O. (2016). Ontogeny of tumor-associated macrophages and its implication in cancer regulation. Trends Cancer 2(1): 20-34.      
  3. Franklin, R. A. and Li, M. O. (2014). The ontogeny of tumor-associated macrophages: a new understanding of cancer-elicited inflammation. Oncoimmunology 3(9): e955346.
  4. Franklin, R. A., Liao, W., Sarkar, A., Kim, M. V., Bivona, M. R., Liu, K., Pamer, E. G. and Li, M. O. (2014). The cellular and molecular origin of tumor-associated macrophages. Science 344(6186): 921-925.
  5. Donkor, M. K., Sarkar, A., Savage, P. A., Franklin, R. A., Johnson, L. K., Jungbluth, A. A., Allison, J. P. and Li, M. O. (2011). T cell surveillance of oncogene-induced prostate cancer is impeded by T cell-derived TGF-beta1 cytokine. Immunity 35(1): 123-134.
  6. Dorrell, M. I., Aguilar, E., Jacobson, R., Trauger, S. A., Friedlander, J., Siuzdak, G. and Friedlander, M. (2010). Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen-induced retinopathy. Glia 58(1): 43-54.
  7. Dorrell, M. I., Aguilar, E., Jacobson, R., Yanes, O., Gariano, R., Heckenlively, J., Banin, E., Ramirez, G. A., Gasmi, M., Bird, A., Siuzdak, G. and Friedlander, M. (2009). Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress. J Clin Invest 119(3): 611-623.
  8. Aguilar, E., Dorrell, M. I., Friedlander, D., Jacobson, R. A., Johnson, A., Marchetti, V., Moreno, S. K., Ritter, M. R. and Friedlander, M. (2008). Chapter 6. Ocular models of angiogenesis. Methods Enzymol 444: 115-158.
  9. Scheppke, L., Aguilar, E., Gariano, R. F., Jacobson, R., Hood, J., Doukas, J., Cao, J., Noronha, G., Yee, S., Weis, S., Martin, M. B., Soll, R., Cheresh, D. A. and Friedlander, M. (2008). Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits. J Clin Invest 118(6): 2337-2346.

1 Protocol published
Determining Leukocyte Origins Using Parabiosis in the PyMT Breast Tumor Model
Authors:  Ruth A. Franklin and Ming O. Li, date: 08/20/2015, view: 4749, Q&A: 0
Tumors develop in a complex microenvironment alongside numerous cell types that impact their survival. Immune cells make up a large proportion of these accessory cells and many are known to promote tumor progression. Macrophages, in particular, are ...
4 Protocols reviewed
In vivo Efficacy Studies in Cell Line and Patient-derived Xenograft Mouse Models
Authors:  Elizabeth A. Tovar, Curt J. Essenburg and Carrie Graveel, date: 01/05/2017, view: 5471, Q&A: 0
In vivo xenograft models derived from human cancer cells have been a gold standard for evaluating the genetic drivers of cancer and are valuable preclinical models for evaluating the efficacy of cancer therapeutics. Recently, ...
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Phagocytosis Assay to Measure Uptake of Necroptotic Cancer Cells by BMDCs
Authors:  Tania Løve Aaes, Dmitri V. Krysko and Peter Vandenabeele, date: 11/05/2016, view: 4692, Q&A: 0
This protocol is a flow cytometry-based method to measure the phagocytosis efficiency of necroptotic target cells by bone marrow-derived dendritic cells (BMDCs) in vitro (Aaes et al., 2016). The method is a slightly modified and ...
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5 Protocols edited
Isolation and Culture of Mouse Lung ILC2s
Authors:  Pauline Schmitt, Anais Duval, Emilie Mirey, Jean-Philippe Girard and Corinne Cayrol, date: 10/05/2018, view: 370, Q&A: 0
Group 2 Innate Lymphoid Cells (ILC2) play an important role in immune responses at barrier surfaces, notably in the lung during airway allergic inflammation or asthma. Several studies have described methods to isolate ILC2s from wild-type naive ...
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High Dimensional Functionomic Analysis of Human Hematopoietic Stem and Progenitor Cells at a Single Cell Level
Authors:  Thomas Luh, Kimberly Lucero, Wenji Ma, Jaeyop Lee, Yu Jerry Zhou, Yufeng Shen and Kang Liu, date: 05/20/2018, view: 1221, Q&A: 0
The ability to conduct investigation of cellular transcription, signaling, and function at the single-cell level has opened opportunities to examine heterogeneous populations at unprecedented resolutions. Although methods have been developed to ...
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