Ming Li Immunology Program, Memorial Sloan Kettering Cancer Center, USA
3 protocols
Benoit Chassaing Georgia State University
14 protocols

Benoit Stijlemans Vrije Universiteit Brussel
5 protocols

Chris Tibbitt Karolinska Institutet
5 protocols

Christina Tan Agency for Science, Technology and Research (A*STAR)
4 protocols

Ruth A. Franklin
  • Yale University
Research focus
  • Immunology
  • 1 Author merit


Ph.D. in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY, 2014

Current position

Postdoctoral Research Fellow, Department of Immunobiology, Yale School of Medicine, New Haven, CT


  1. Dadi, S., Chhangawala, S., Whitlock, B. M., Franklin, R. A., Luo, C. T., Oh, S. A., Toure, A., Pritykin, Y., Huse, M., Leslie, C. S. and Li, M. O. (2016). Cancer immunosurveillance by tissue-resident innate lymphoid cells and innate-like T cells. Cell 164(3): 365-377.
  2. Franklin, R. A. and Li, M. O. (2016). Ontogeny of tumor-associated macrophages and its implication in cancer regulation. Trends Cancer 2(1): 20-34.      
  3. Franklin, R. A. and Li, M. O. (2014). The ontogeny of tumor-associated macrophages: a new understanding of cancer-elicited inflammation. Oncoimmunology 3(9): e955346.
  4. Franklin, R. A., Liao, W., Sarkar, A., Kim, M. V., Bivona, M. R., Liu, K., Pamer, E. G. and Li, M. O. (2014). The cellular and molecular origin of tumor-associated macrophages. Science 344(6186): 921-925.
  5. Donkor, M. K., Sarkar, A., Savage, P. A., Franklin, R. A., Johnson, L. K., Jungbluth, A. A., Allison, J. P. and Li, M. O. (2011). T cell surveillance of oncogene-induced prostate cancer is impeded by T cell-derived TGF-beta1 cytokine. Immunity 35(1): 123-134.
  6. Dorrell, M. I., Aguilar, E., Jacobson, R., Trauger, S. A., Friedlander, J., Siuzdak, G. and Friedlander, M. (2010). Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen-induced retinopathy. Glia 58(1): 43-54.
  7. Dorrell, M. I., Aguilar, E., Jacobson, R., Yanes, O., Gariano, R., Heckenlively, J., Banin, E., Ramirez, G. A., Gasmi, M., Bird, A., Siuzdak, G. and Friedlander, M. (2009). Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress. J Clin Invest 119(3): 611-623.
  8. Aguilar, E., Dorrell, M. I., Friedlander, D., Jacobson, R. A., Johnson, A., Marchetti, V., Moreno, S. K., Ritter, M. R. and Friedlander, M. (2008). Chapter 6. Ocular models of angiogenesis. Methods Enzymol 444: 115-158.
  9. Scheppke, L., Aguilar, E., Gariano, R. F., Jacobson, R., Hood, J., Doukas, J., Cao, J., Noronha, G., Yee, S., Weis, S., Martin, M. B., Soll, R., Cheresh, D. A. and Friedlander, M. (2008). Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits. J Clin Invest 118(6): 2337-2346.

1 Protocol published
Determining Leukocyte Origins Using Parabiosis in the PyMT Breast Tumor Model
Authors:  Ruth A. Franklin and Ming O. Li, date: 08/20/2015, view: 8526, Q&A: 0
Tumors develop in a complex microenvironment alongside numerous cell types that impact their survival. Immune cells make up a large proportion of these accessory cells and many are known to promote tumor progression. Macrophages, in particular, are ...
5 Protocols reviewed
RNA Sequencing of Single Myofibers from Mus musculus
Authors:  Darren M. Blackburn, Felicia Lazure and Vahab D. Soleimani, date: 02/20/2020, view: 3954, Q&A: 0
Whole transcriptome analysis is a key method in biology that allows researchers to determine the effect a condition has on gene regulation. One difficulty in RNA sequencing of muscle is that traditional methods are performed on the whole muscle, but ...
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In vivo Efficacy Studies in Cell Line and Patient-derived Xenograft Mouse Models
Authors:  Elizabeth A. Tovar, Curt J. Essenburg and Carrie Graveel, date: 01/05/2017, view: 12046, Q&A: 0
In vivo xenograft models derived from human cancer cells have been a gold standard for evaluating the genetic drivers of cancer and are valuable preclinical models for evaluating the efficacy of cancer therapeutics. Recently, ...
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11 Protocols edited
Isolation and Long-term Cultivation of Mouse Alveolar Macrophages
Alveolar macrophages (AM) are tissue-resident macrophages that colonize the lung around birth and can self-maintain long-term in an adult organism without contribution of monocytes. AM are located in the pulmonary alveoli and can be harvested by ...
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Characterization of Mouse Adult Testicular Macrophage Populations by Immunofluorescence Imaging and Flow Cytometry
Authors:  Noushin Mossadegh-Keller and Michael H. Sieweke, date: 03/05/2019, view: 4172, Q&A: 0
Testicular macrophages (tMΦ) are the most abundant immune cells residing in the testis, an immune-privileged organ. TMΦ are known to exhibit different functions, such as protecting spermatozoa from auto-immune attack by producing immunosuppressive ...
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