Matilda Chan University of California
2 protocols

Zena Werb
  • Department of Anatomy, University of California, USA
Research focus
  • Immunology
  • 2 Author merit


Ph.D. in Cell Biology, Rockefeller University, New York, 1971

Current position

Professor and vice-Chair, Department of Anatomy, University of California, San Francisco

Publications (>450 total full publications)

  1. Casbon, A. J., Reynaud, D., Park, C., Khuc, E., Gan, D. D., Schepers, K., Passegue, E. and Werb, Z. (2015). Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils. Proc Natl Acad Sci U S A 112(6): E566-575.
  2. Plaks, V., Kong, N. and Werb, Z. (2015). The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? Cell Stem Cell 16(3): 225-238.
  3. Lohela, M., Casbon, A. J., Olow, A., Bonham, L., Branstetter, D., Weng, N., Smith, J. and Werb, Z. (2014). Intravital imaging reveals distinct responses of depleting dynamic tumor-associated macrophage and dendritic cell subpopulations. Proc Natl Acad Sci U S A 111(47): E5086-5095.
  4. Kessenbrock, K., Dijkgraaf, G. J., Lawson, D. A., Littlepage, L. E., Shahi, P., Pieper, U. and Werb, Z. (2013). A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell 13(3): 300-313.
  5. Plaks, V., Brenot, A., Lawson, D. A., Linnemann, J. R., Van Kappel, E. C., Wong, K. C., de Sauvage, F., Klein, O. D. and Werb, Z. (2013). Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Rep 3(1): 70-78.
  6. Chou, J., Lin, J. H., Brenot, A., Kim, J. W., Provot, S. and Werb, Z. (2013). GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. Nat Cell Biol 15(2): 201-213.
  7. Kessenbrock, K., Plaks, V. and Werb, Z. (2010). Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141(1): 52-67.
  8. Ewald, A. J., Brenot, A., Duong, M., Chan, B. S. and Werb, Z. (2008). Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis. Dev Cell 14(4): 570-581.
  9. Coussens, L. M. and Werb, Z. (2002). Inflammation and cancer. Nature 420(6917): 860-867.
  10. Vu, T. H., Shipley, J. M., Bergers, G., Berger, J. E., Helms, J. A., Hanahan, D., Shapiro, S. D., Senior, R. M. and Werb, Z. (1998). MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell 93(3): 411-422.
2 Protocols published
Authors:  Matilda F. Chan and Zena Werb, date: 07/05/2015, view: 10076, Q&A: 0
The accessibility and transparency of the cornea makes it a good tissue model for monitoring immunological responses using in vivo real time imaging analysis (Lee et al., 2010; Tan et al., 2013). These corneal qualities ...
Authors:  Matilda F. Chan and Zena Werb, date: 07/05/2015, view: 8509, Q&A: 0
The cornea is an excellent model system to use for the analysis of wound repair because of its accessibility, lack of vascularization, and simple anatomy. Corneal injuries may involve only the superficial epithelial layer or may penetrate deeper to ...
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