Pablo Pelegrín Inflammation and Experimental Surgery Unit, Clinical University Hospital "Virgen de la Arrixaca", Spain
2 protocols

Ana Gómez Inflammation and Experimental Surgery Unit, Clinical University Hospital "Virgen de la Arrixaca", Spain
1 protocol

Fátima Martín-Sánchez
  • Inflammation and Experimental Surgery Unit, Clinical University Hospital "Virgen de la Arrixaca", Spain
  • 1 Author merit


Ph.D. in Biology, University of Murcia, Murcia, Spain, 2011

Current position

Postdoctoral Research Associate, Murcia´s BioHealth Research Institute, University of Murcia, Murcia, Spain (2013-to date)


  1. Compan, V., Martin-Sanchez, F., Baroja-Mazo, A., Lopez-Castejon, G., Gomez, A. I., Verkhratsky, A., Brough, D. and Pelegrin, P. (2015). Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling. J Immunol 194(3): 1261-1273.
  2. Baroja-Mazo, A., Martin-Sanchez, F., Gomez, A. I., Martinez, C. M., Amores-Iniesta, J., Compan, V., Barbera-Cremades, M., Yague, J., Ruiz-Ortiz, E., Anton, J., Bujan, S., Couillin, I., Brough, D., Arostegui, J. I. and Pelegrin, P. (2014). The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. Nat Immunol 15(8): 738-748.
  3. Martin, F., Nunez, C., Marin, M. T., Laorden, M. L., Kovacs, K. J. and Milanes, M. V. (2012). Involvement of noradrenergic transmission in the PVN on CREB activation, TORC1 levels, and pituitary-adrenal axis activity during morphine withdrawal. PLoS One 7(2): e31119.
  4. Martin, F., Mora, L., Laorden, M. and Milanes, M. (2011). Protein kinase C phosphorylates the cAMP response element binding protein in the hypothalamic paraventricular nucleus during morphine withdrawal. Br J Pharmacol 163(4): 857-875.
  5. Ferenczi, S., Nunez, C., Pinter-Kubler, B., Foldes, A., Martin, F., Markus, V. L., Milanes, M. V. and Kovacs, K. J. (2010). Changes in metabolic-related variables during chronic morphine treatment. Neurochem Int 57(3): 323-330.
  6. Nunez, C., Martin, F., Foldes, A., Luisa Laorden, M., Kovacs, K. J. and Victoria Milanes, M. (2010). Induction of FosB/DeltaFosB in the brain stress system-related structures during morphine dependence and withdrawal. J Neurochem 114(2): 475-487.
  7. Martin, F., Laorden, M. L. and Milanes, M. V. (2009). Morphine withdrawal regulates phosphorylation of cAMP response element binding protein (CREB) through PKC in the nucleus tractus solitarius-A2 catecholaminergic neurons. J Neurochem 110(5): 1422-1432.
1 Protocol published
Isolation of Particles of Recombinant ASC and NLRP3
Authors:  Fátima Martín-Sánchez, Ana I. Gómez and Pablo Pelegrín, date: 05/20/2015, view: 7326, Q&A: 0
NLRP3 inflammasome is a multiprotein complex responsible for the activation of inflammatory caspase-1, resulting in processing and release of pro-inflammatory cytoquines IL-1β and IL-18 (Schroder and Tschopp, 2010). This inflammasome is composed of ...
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