Carlos Tadokoro Universidade de Vila Velha, Brazil
2 protocols

Henrique Borges da Silva University of Minnesota
2 protocols

Elena Lassunskaia Laboratório de Biologia do Reconhecer, Universidade Estadual do Norte Fluminense (UENF), Brazil
1 protocol

Eduardo Amaral Departamento de Imunologia, Instituto de Ciências Biomédicas (ICB), Universidade de São Paulo (USP), Brazil
1 protocol

Maria Regina D’Império-Lima
  • Instituto de Ciências Biomédicas, Universidade de São Paulo, Brazil
Research focus
  • Immunology
  • 3 Author merit


Ph.D. in Parasitology Program at USP, 1992

Current position

Associate Professor: Department of Immunology at USP


  1. Borges da Silva, H., Fonseca, R., Cassado Ados, A., Machado de Salles, E., de Menezes, M. N., Langhorne, J., Perez, K. R., Cuccovia, I. M., Ryffel, B., Barreto, V. M., Marinho, C. R., Boscardin, S. B., Alvarez, J. M., D'Imperio-Lima, M. R. and Tadokoro, C. E. (2015). In vivo approaches reveal a key role for DCs in CD4+ T cell activation and parasite clearance during the acute phase of experimental blood-stage malaria. PLoS Pathog 11(2): e1004598.

  2. Amaral, E. P., Ribeiro, S. C., Lanes, V. R., Almeida, F. M., de Andrade, M. R., Bomfim, C. C., Salles, E. M., Bortoluci, K. R., Coutinho-Silva, R., Hirata, M. H., Alvarez, J. M., Lasunskaia, E. B. and D'Imperio-Lima, M. R. (2014). Pulmonary infection with hypervirulent Mycobacteria reveals a crucial role for the P2X7 receptor in aggressive forms of tuberculosis. PLoS Pathog 10(7): e1004188.

  3. Lage, S. L., Buzzo, C. L., Amaral, E. P., Matteucci, K. C., Massis, L. M., Icimoto, M. Y., Carmona, A. K., D'Imperio Lima, M. R., Rodrigues, M. M., Ferreira, L. C., Amarante-Mendes, G. P. and Bortoluci, K. R. (2013). Cytosolic flagellin-induced lysosomal pathway regulates inflammasome-dependent and -independent macrophage responses. Proc Natl Acad Sci U S A 110(35): E3321-3330.

  4. da Silva, H. B., de Salles, E. M., Panatieri, R. H., Boscardin, S. B., Rodriguez-Malaga, S. M., Alvarez, J. M. and D'Imperio Lima, M. R. (2013). IFN-gamma-induced priming maintains long-term strain-transcending immunity against blood-stage Plasmodium chabaudi malaria. J Immunol 191(10): 5160-5169.

  5. Freitas do Rosario, A. P., Muxel, S. M., Rodriguez-Malaga, S. M., Sardinha, L. R., Zago, C. A., Castillo-Mendez, S. I., Alvarez, J. M. and D'Imperio Lima, M. R. (2008). Gradual decline in malaria-specific memory T cell responses leads to failure to maintain long-term protective immunity to Plasmodium chabaudi AS despite persistence of B cell memory and circulating antibody. J Immunol 181(12): 8344-8355.

  6. Elias, R. M., Sardinha, L. R., Bastos, K. R., Zago, C. A., da Silva, A. P., Alvarez, J. M. and Lima, M. R. (2005). Role of CD28 in polyclonal and specific T and B cell responses required for protection against blood stage malaria. J Immunol 174(2): 790-799.

  7. Bastos, K. R., Marinho, C. R., Barboza, R., Russo, M., Alvarez, J. M. and D'Imperio Lima, M. R. (2004). What kind of message does IL-12/IL-23 bring to macrophages and dendritic cells? Microbes Infect 6(6): 630-636.

  8. Bastos, K. R., Alvarez, J. M., Marinho, C. R., Rizzo, L. V. and Lima, M. R. (2002). Macrophages from IL-12p40-deficient mice have a bias toward the M2 activation profile. J Leukoc Biol 71(2): 271-278.

  9. d'Imperio Lima, M. R., Eisen, H., Minoprio, P., Joskowicz, M. and Coutinho, A. (1986). Persistence of polyclonal B cell activation with undetectable parasitemia in late stages of experimental Chagas' disease. J Immunol 137(1): 353-356.

  10. D'Imperio Lima, M. R., Joskowicz, M., Coutinho, A., Kipnis, T. and Eisen, H. (1985). Very large and isotypically atypical polyclonal plaque-forming cell responses in mice infected with Trypanosoma cruzi. Eur J Immunol 15(2): 201-203.

3 Protocols published
To evaluate precisely the relative roles of different splenic phagocytic cells during an immune response, efficient methods for the depletion of specific populations are needed. Here, we describe the protocols for the depletion of splenic dendritic ...
Efficient staining methods to identify Plasmodium-infected red blood cells (iRBCs) are crucial to discriminate precisely the immune cells responsible for their elimination from circulation. Here, we describe the protocol for the ...
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