Oliver Brüstle Institute of Reconstructive Neurobiology, University of Bonn and Hertie Foundation, Germany
1 protocol

Philipp Koch Institute of Reconstructive Neurobiology, University of Bonn and Hertie Foundation, Germany
1 protocol

Julia Ladewig
  • Institute of Reconstructive Neurobiology, University of Bonn and Hertie Foundation, Germany
Research focus
  • Neuroscience
  • 1 Author merit


Ph.D. in Biology, Institute of Reconstructive Neurobiology, University of Bonn, 2008

Current position

Independent Junior Group Leader, Institute of Reconstructive Neurobiology, University of Bonn, Germany


  1. Ladewig, J.*, Koch, P.* and Brustle, O. (2014). Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration. Nat Neurosci 17(1): 24-26. (IF: 15.251)
  2.  Ladewig, J.*, Koch, P.* and Brustle, O. (2013). Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies. Nat Rev Mol Cell Biol 14(4): 225-236. (IF: 39,123)
  3. Mertens, J., Stuber, K., Wunderlich, P., Ladewig, J., Kesavan, J. C., Vandenberghe, R., Vandenbulcke, M., van Damme, P., Walter, J., Brustle, O. and Koch, P. (2013). APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based gamma-secretase modulation. Stem Cell Reports 1(6): 491-498. (IF: no IF yet)
  4. Mertens, J., Stuber, K., Poppe, D., Doerr, J., Ladewig, J., Brustle, O.* and Koch, P.* (2013). Embryonic stem cell-based modeling of tau pathology in human neurons. Am J Pathol 182(5): 1769-1779. (IF: 5.224)
  5. Koch, P., Tamboli, I. Y., Mertens, J., Wunderlich, P., Ladewig, J., Stuber, K., Esselmann, H., Wiltfang, J., Brustle, O. and Walter, J. (2012). Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of gamma-secretase activity in endogenous amyloid-beta generation. Am J Pathol 180(6): 2404-2416. (IF: 5.224)
  6. Ladewig, J., Mertens, J.*, Kesavan, J.*, Doerr, J., Poppe, D., Glaue, F., Herms, S., Wernet, P., Kogler, G., Muller, F. J., Koch, P.* and Brustle, O.* (2012). Small molecules enable highly efficient neuronal conversion of human fibroblasts. Nat Methods 9(6): 575-578. (IF: 23.565)
  7. Oki, K.*, Tatarishvili, J.*, Wood, J.*, Koch, P.*, Wattananit, S., Mine, Y., Monni, E., Tornero, D., Ahlenius, H., Ladewig, J., Brustle, O., Lindvall, O. and Kokaia, Z. (2012). Human-induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke-damaged brain. Stem Cells 30(6): 1120-1133. (*Equal contribution) (IF: 7.871)
  8. Falk, A.*, Koch, P.*, Kesavan, J., Takashima, Y., Ladewig, J., Alexander, M., Wiskow, O., Tailor, J., Trotter, M., Pollard, S., Smith, A. and Brustle, O. (2012). Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons. PLoS One 7(1): e29597. (IF: 4.411)
  9. Koch, P., Breuer, P., Peitz, M., Jungverdorben, J., Kesavan, J., Poppe, D., Doerr, J., Ladewig, J., Mertens, J., Tuting, T., Hoffmann, P., Klockgether, T., Evert, B. O., Wullner, U. and Brustle, O. (2011). Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease. Nature 480(7378): 543-546. (IF: 38.597)
  10. Koch, P., Opitz, T., Steinbeck, J. A., Ladewig, J. and Brustle, O. (2009). A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration. Proc Natl Acad Sci U S A 106(9): 3225-3230. (IF: 9.971)
  11. Ladewig, J.*, Koch, P.*, Endl, E., Meiners, B., Opitz, T., Couillard-Despres, S., Aigner, L. and Brustle, O. (2008). Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons. Stem Cells 26(7): 1705-1712. (*Equal contribution) (IF: 7.871)
  12. Kruger, O., Ladewig, J., Koster, K. and Ragg, H. (2002). Widespread occurrence of serpin genes with multiple reactive centre-containing exon cassettes in insects and nematodes. Gene 293(1-2): 97-105. (IF: 2.196)
1 Protocol published
In vitro Migration Assays for Neural Stem Cells, Intermediate Neurogenic Progenitors and Immature Neurons
Authors:  Julia Ladewig, Philipp Koch and Oliver Brüstle, date: 01/05/2015, view: 16171, Q&A: 0
In the vertebrate central nervous system (CNS), different neural precursor populations such as neural stem cells (NSCs), intermediate neurogenic progenitors (INPs) and immature neurons have to migrate from their places of birth to their location of ...
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