Susan Uprichard Department of Medicine, Loyola University Medical Center, USA
1 protocol

Naina Barretto
  • Department of Medicine, Loyola University Medical Center, USA
Research focus
  • Microbiology
  • 1 Author merit


Ph.D. in Virology, Department of Immunology and Virology, Rush University, 2003

Current position

Senior Medical Writer, Global Medical Publishing, AbbVie Inc., North Chicago, IL, USA


  1. Barretto, N., Sainz, B., Jr., Hussain, S. and Uprichard, S. L. (2014). Determining the involvement and therapeutic implications of host cellular factors in hepatitis C virus cell-to-cell spread. J Virol 88(9): 5050-5061.
  2. Hussain, S., Barretto, N. and Uprichard, S. L. (2012). New hepatitis C virus drug discovery strategies and model systems. Expert Opin Drug Discov 7(9): 849-859.
  3. Sainz, B., Jr., Barretto, N., Martin, D. N., Hiraga, N., Imamura, M., Hussain, S., Marsh, K. A., Yu, X., Chayama, K., Alrefai, W. A. and Uprichard, S. L. (2012). Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor. Nat Med 18(2): 281-285.
  4. Sainz, B., Jr., Barretto, N., Yu, X., Corcoran, P. and Uprichard, S. L. (2012). Permissiveness of human hepatoma cell lines for HCV infection. Virol J 9: 30.
  5. Sainz, B., Jr., Barretto, N. and Uprichard, S. L. (2009). Hepatitis C virus infection in phenotypically distinct Huh7 cell lines. PLoS One 4(8): e6561.
  6. Devaraj, S. G., Wang, N., Chen, Z., Chen, Z., Tseng, M., Barretto, N., Lin, R., Peters, C. J., Tseng, C. T., Baker, S. C. and Li, K. (2007). Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus. J Biol Chem 282(44): 32208-32221.
  7. Ratia, K., Saikatendu, K. S., Santarsiero, B. D., Barretto, N., Baker, S. C., Stevens, R. C. and Mesecar, A. D. (2006). Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme. Proc Natl Acad Sci U S A 103(15): 5717-5722.
  8. Barretto, N., Jukneliene, D., Ratia, K., Chen, Z., Mesecar, A. D. and Baker, S. C. (2005). The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity. J Virol 79(24): 15189-15198. (Selected for JVI spotlight)
  9. Barretto, N., Hallak, L. K. and Peeples, M. E. (2003). Neuraminidase treatment of respiratory syncytial virus-infected cells or virions, but not target cells, enhances cell-cell fusion and infection. Virology 313(1): 33-43.
  10. Techaarpornkul, S., Barretto, N. and Peeples, M. E. (2001). Functional analysis of recombinant respiratory syncytial virus deletion mutants lacking the small hydrophobic and/or attachment glycoprotein gene. J Virol 75(15): 6825-6834.

Book chapters

  1. Barretto, N., Jukneliene, D., Ratia, K., Chen, Z., Mesecar, A. D. and Baker, S. C. (2006). Deubiquitinating activity of the SARS-CoV papain-like protease. Adv Exp Med Biol 581: 37-41.
1 Protocol published
Authors:  Naina Barretto and Susan L. Uprichard, date: 12/20/2014, view: 9263, Q&A: 1
Hepatitis C virus (HCV) can infect naïve cells via entry of “cell-free” extracellular virus or direct “cell-to-cell” transmission. Here, we describe an assay for detecting HCV cell-to-cell transmission, using a non-growing cell culture system that ...
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