Mabel Padilla Molecular Biology and Lung Cancer, Lovelace Respiratory Research Institute, USA
1 protocol

Xiuling Xu Molecular Biology and Lung Cancer, Lovelace Respiratory Research Institute, USA
1 protocol

Yong Lin
  • Molecular Biology and Lung Cancer, Lovelace Respiratory Research Institute, USA
Research focus
  • Immunology
  • 1 Author merit


Ph.D. in Molecular Biology, Kanazawa University, Kanazawa, Japan, 1998

Current position

Scientist, Principle Investigator, Lung Cancer and Molecular Biology Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA

Publications (since 2010)

  1. Chen, W., Wang, Q., Bai, L., Chen, W., Wang, X., Tellez, C. S., Leng, S., Padilla, M. T., Nyunoya, T., Belinsky, S. A. and Lin, Y. (2014). RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1alpha-mediated mitochondrial oxidative phosphorylation and glycolysis. Cell Death Differ 21(7): 1061-1070,
  2. Xu, X., Padilla, M. T., Li, B., Wells, A., Kato, K., Tellez, C., Belinsky, S. A., Kim, K. C. and Lin, Y. (2014). MUC1 in macrophage: contributions to cigarette smoke-induced lung cancer. Cancer Res 74(2): 460-470,
  3. He, W., Wang, Q., Srinivasan, B., Xu, J., Padilla, M. T., Li, Z., Wang, X., Liu, Y., Gou, X., Shen, H. M., Xing, C.* and Lin, Y. (2014). A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy. Oncogene 33(23): 3004-3013.
  4. Xu, X., Wells, A., Padilla, M. T., Kato, K., Kim, K. C. and Lin, Y.* (2014). A signaling pathway consisting of miR-551b, catalase and MUC1 contributes to acquired apoptosis resistance and chemoresistance. Carcinogenesis: bgu159. (Epub ahead of print)
  5. Wang, Q., Chen, W., Bai, L., Chen, W., Padilla, M. T., Lin, A. S., Shi, S., Wang, X. and Lin, Y. (2014). Receptor-interacting protein 1 increases chemoresistance by maintaining inhibitor of apoptosis protein levels and reducing reactive oxygen species through a microRNA-146a-mediated catalase pathway. J Biol Chem 289(9): 5654-5663.
  6. Wang, Q., Shi, S., He, W., Padilla, M. T., Zhang, L., Wang, X., Zhang, B. and Lin, Y. (2014). Retaining MKP1 expression and attenuating JNK-mediated apoptosis by RIP1 for cisplatin resistance through miR-940 inhibition. Oncotarget 5(5): 1304-1314.
  7. Jang, J. H., Bruse, S., Huneidi, S., Schrader, R. M., Monick, M. M., Lin, Y., Carter, A. B., Klingelhutz, A. J. and Nyunoya, T. (2014). Acrolein-Exposed Normal Human Lung Fibroblasts in Vitro: Cellular Senescence, Enhanced Telomere Erosion, and Degradation of Werner's Syndrome Protein. Environ Health Perspect 122(9): 955-962.
  8. Jang, J. H., Bruse, S., Liu, Y., Duffy, V., Zhang, C., Oyamada, N., Randell, S., Matsumoto, A., Thompson, D. C., Lin, Y., Vasiliou, V., Tesfaigzi, Y. and Nyunoya, T. (2014). Aldehyde dehydrogenase 3A1 protects airway epithelial cells from cigarette smoke-induced DNA damage and cytotoxicity. Free Radic Biol Med 68: 80-86.
  9. Wang, Q., Chen, W., Xu, X., Li, B., He, W., Padilla, M. T., Jang, J. H., Nyunoya, T., Amin, S., Wang, X. and Lin, Y. (2013). RIP1 potentiates BPDE-induced transformation in human bronchial epithelial cells through catalase-mediated suppression of excessive reactive oxygen species. Carcinogenesis 34(9): 2119-2128.
  10. Leng, S., Picchi, M. A., Liu, Y., Thomas, C. L., Willis, D. G., Bernauer, A. M., Carr, T. G., Mabel, P. T., Han, Y., Amos, C. I., Lin, Y., Stidley, C. A., Gilliland, F. D., Jacobson, M. R. and Belinsky, S. A. (2013). Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau. Carcinogenesis 34(5): 1044-1050.
  11. Scott, B. R., Hutt, J., Lin, Y., Padilla, M. T., Gott, K. M. and Potter, C. A. (2013). Biological microdosimetry based on radiation cytotoxicity data. Radiat Prot Dosimetry 153(4): 417-424.
  12. He, W., Wang, Q., Xu, J., Xu, X., Padilla, M. T., Ren, G., Gou, X. and Lin, Y. (2012). Attenuation of TNFSF10/TRAIL-induced apoptosis by an autophagic survival pathway involving TRAF2- and RIPK1/RIP1-mediated MAPK8/JNK activation. Autophagy 8(12): 1811-1821.
  13. Chen, W., Xu, X., Bai, L., Padilla, M. T., Gott, K. M., Leng, S., Tellez, C. S., Wilder, J. A., Belinsky, S. A., Scott, B. R. and Lin, Y. (2012). Low-dose gamma-irradiation inhibits IL-6 secretion from human lung fibroblasts that promotes bronchial epithelial cell transformation by cigarette-smoke carcinogen. Carcinogenesis 33(7): 1368-1374.
  14. Xu, X., Bai, L., Chen, W., Padilla, M. T., Liu, Y., Kim, K. C., Belinsky, S. A. and Lin, Y. (2012). MUC1 contributes to BPDE-induced human bronchial epithelial cell transformation through facilitating EGFR activation. PLoS One 7(3): e33846.
  15. Bai, L., Xu, X., Wang, Q., Xu, S., Ju, W., Wang, X., Chen, W., He, W., Tang, H. and Lin, Y. (2012). A superoxide-mediated mitogen-activated protein kinase phosphatase-1 degradation and c-Jun NH(2)-terminal kinase activation pathway for luteolin-induced lung cancer cytotoxicity. Mol Pharmacol 81(4): 549-555.
  16. Choksi, S.#, Lin, Y.#, Pobezinskaya, Y.#, Chen, L.#, Park, C., Morgan, M., Li, T., Jitkaew, S., Cao, X., Kim, Y. S., Kim, H. S., Levitt, P., Shih, G., Birre, M., Deng, C. X. and Liu, Z. G. (2011). A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2. Mol Cell 42(5): 597-609. (#Equal contributions)
  17. Li, Z., Xu, X., Bai, L., Chen, W. and Lin, Y. (2011). Epidermal growth factor receptor-mediated tissue transglutaminase overexpression couples acquired tumor necrosis factor-related apoptosis-inducing ligand resistance and migration through c-FLIP and MMP-9 proteins in lung cancer cells. J Biol Chem 286(24): 21164-21172.
  18. Xu, J., Xu, F. and Lin, Y. (2011). Cigarette smoke synergizes lipopolysaccharide-induced interleukin-1beta and tumor necrosis factor-alpha secretion from macrophages via substance P-mediated nuclear factor-kappaB activation. Am J Respir Cell Mol Biol 44(3): 302-308.
  19. Kim, J. Y., Morgan, M., Kim, D. G., Lee, J. Y., Bai, L., Lin, Y., Liu, Z. G. and Kim, Y. S. (2011). TNFalpha induced noncanonical NF-kappaB activation is attenuated by RIP1 through stabilization of TRAF2. J Cell Sci 124(Pt 4): 647-656.
  20. Bai, L., Xu, S., Chen, W., Li, Z., Wang, X., Tang, H. and Lin, Y. (2011). Blocking NF-kappaB and Akt by Hsp90 inhibition sensitizes Smac mimetic compound 3-induced extrinsic apoptosis pathway and results in synergistic cancer cell death. Apoptosis 16(1): 45-54.
  21. Chen, W., Li, Z., Bai, L. and Lin, Y. (2011). NF-kappaB in lung cancer, a carcinogenesis mediator and a prevention and therapy target. Front Biosci (Landmark Ed) 16: 1172-1185.
  22. Wang, Q., Zheng, X. L., Yang, L., Shi, F., Gao, L. B., Zhong, Y. J., Sun, H., He, F., Lin, Y. and Wang, X. (2010). Reactive oxygen species-mediated apoptosis contributes to chemosensitization effect of saikosaponins on cisplatin-induced cytotoxicity in cancer cells. J Exp Clin Cancer Res 29: 159.
  23. Kamarajan, P., Bunek, J., Lin, Y., Nunez, G. and Kapila, Y. L. (2010). Receptor-interacting protein shuttles between cell death and survival signaling pathways. Mol Biol Cell 21(3): 481-488.
  24. Lin, Y., Bai, L., Chen, W. and Xu, S. (2010). The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy. Expert Opin Ther Targets 14(1): 45-55. (*Corresponding author)
  25. Chen, W., Bai, L., Wang, X., Xu, S., Belinsky, S. A. and Lin, Y. (2010). Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosis. Mol Pharmacol 77(3): 416-423.
1 Protocol published
Measurement of TACE Activity in Extracts from Cultured Cells
Authors:  Xiuling Xu, Mabel T. Padilla and Yong Lin, date: 10/20/2014, view: 7507, Q&A: 0
In cigarette smoke–induced and inflammation-associated lung cancer development, cigarette smoke extract (CSE) activates tumor necrosis factor-alpha (TNF-α) secretion from macrophages. TNF-α converting enzyme (TACE), also known as α-Secretase or ...
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