Luciana Leo Neuroscience Department, D'Or Institute for Research and Education (IDOR) and FIOCRUZ, Brazil
1 protocol

Fabricio A. Pamplona
  • Neuroscience Department, D'Or Institute for Research and Education (IDOR), Brazil
  • 1 Author merit


Ph.D. in Psychopharmacology, Federal University of Santa Catarina, 2010

Current position

Scientific Researcher in Neuroscience, D'Or Institute for Research and Education (IDOR) (2012-present); National Laboratory of Stem Cells (LaNCE-UFRJ) (2014-present)


Selected peer-reviewed (14 out of 30, over 900 citations)

  1. Bitencourt, R. M., Pamplona, F. A. and Takahashi, R. N. (2014). Corticosteroid-endocannabinoid loop supports decrease of fear-conditioned response in rats. Eur Neuropsychopharmacol 24(7): 1091-1102.
  2. De Carvalho, C. R., Pamplona, F. A., Cruz, J. S. and Takahashi, R. N. (2014). Endocannabinoids underlie reconsolidation of hedonic memories in Wistar rats. Psychopharmacology (Berl) 231(7): 1417-1425.
  3. Leo, L. M., Almeida-Correa, S., Canetti, C. A., Amaral, O. B., Bozza, F. A. and Pamplona, F. A. (2014). Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice. PLoS One 9(1): e85009.
  4. de Bitencourt, R. M.*, Pamplona, F. A.* and Takahashi, R. N. (2013). A current overview of cannabinoids and glucocorticoids in facilitating extinction of aversive memories: potential extinction enhancers. Neuropharmacology 64: 389-395
  5. Riebe, C. J.*, Pamplona, F. A.*, Kamprath, K. and Wotjak, C. T. (2012). Fear relief-toward a new conceptual frame work and what endocannabinoids gotta do with it. Neuroscience 204: 159-185.
  6. Pamplona, F. A. and Takahashi, R. N. (2012). Psychopharmacology of the endocannabinoids: far beyond anandamide. J Psychopharmacol 26(1): 7-22.
  7. Pamplona, F. A., Ferreira, J., Menezes de Lima, O., Jr., Duarte, F. S., Bento, A. F., Forner, S., Villarinho, J. G., Bellocchio, L., Wotjak, C. T., Lerner, R., Monory, K., Lutz, B., Canetti, C., Matias, I., Calixto, J. B., Marsicano, G., Guimaraes, M. Z. and Takahashi, R. N. (2012). Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor. Proc Natl Acad Sci U S A 109(51): 21134-21139.
  8. Pamplona, F. A., Henes, K., Micale, V., Mauch, C. P., Takahashi, R. N. and Wotjak, C. T. (2011). Prolonged fear incubation leads to generalized avoidance behavior in mice. J Psychiatr Res 45(3): 354-360.
  9. Pamplona, F. A., Menezes-de-Lima, O., Jr. and Takahashi, R. N. (2010). Aspirin-triggered lipoxin induces CB1-dependent catalepsy in mice. Neurosci Lett 470(1): 33-37.
  10. Pamplona, F. A., Bitencourt, R. M. and Takahashi, R. N. (2008). Short- and long-term effects of cannabinoids on the extinction of contextual fear memory in rats. Neurobiol Learn Mem 90(1): 290-293.
  11. Bitencourt, R. M., Pamplona, F. A. and Takahashi, R. N. (2008). Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats. Eur Neuropsychopharmacol 18(12): 849-859.
  12. Pamplona, F. A., Prediger, R. D., Pandolfo, P. and Takahashi, R. N. (2006). The cannabinoid receptor agonist WIN 55,212-2 facilitates the extinction of contextual fear memory and spatial memory in rats. Psychopharmacology (Berl) 188(4): 641-649.
  13. Pamplona, F. A. and Takahashi, R. N. (2006). WIN 55212-2 impairs contextual fear conditioning through the activation of CB1 cannabinoid receptors. Neurosci Lett 397(1-2): 88-92.
  14. Takahashi, R. N., Pamplona, F. A. and Fernandes, M. S. (2005). The cannabinoid antagonist SR141716A facilitates memory acquisition and consolidation in the mouse elevated T-maze. Neurosci Lett 380(3): 270-275.
1 Protocol published
Elevated Plus Maze Test to Assess Anxiety-like Behavior in the Mouse
Authors:  Luciana M. Leo and Fabricio A. Pamplona, date: 08/20/2014, view: 19355, Q&A: 0
The elevated plus maze task is a simple method to assess anxiety-like behaviors in rodents. This version describes the procedure used in mice. However, the protocol may also be applied to rats, considering a proportionally larger apparatus (arms: 10 ...
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