Claudia Kemper MRC Centre for Transplantation, King's College, UK
1 protocol
Alka Mehra Institute of Genomics and Integrative Biology
21 protocols

Cody Kime Center of Developmental Biology, RIKEN
2 protocols

Elizabeth Clarke Center for Health Research-Kaiser Permanente
6 protocols

Emmanuel Orta-Zavalza Universidad Autónoma de Ciudad Juárez
7 protocols

Reviewer
Martin V Kolev
  • Investigator Complement Biology, GSK Research and Development
Research focus
  • Immunology
  • T cells, intracellular complement, metabolism
  • 1 Author merit

Education

PhD, Cardiff University

Publications

Keeping It All Going-Complement Meets Metabolism. Kolev M, Kemper C.
Front Immunol. 2017 Jan 18;8:1. doi: 10.3389/fimmu.2017.00001. eCollection 2017. Review.

Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses.
Kolev M, Dimeloe S, Le Friec G, Navarini A, Arbore G, Povoleri GA, Fischer M, Belle R, Loeliger J, Develioglu L, Bantug GR, Watson J, Couzi L, Afzali B, Lavender P, Hess C, Kemper C.
Immunity. 2015 Jun 16;42(6):1033-47. doi: 10.1016/j.immuni.2015.05.024.
Complement--tapping into new sites and effector systems.
Kolev M, Le Friec G, Kemper C.
Nat Rev Immunol. 2014 Dec;14(12):811-20. doi: 10.1038/nri3761. Epub 2014 Nov 14. Review.
Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation.
Liszewski MK, Kolev M, Le Friec G, Leung M, Bertram PG, Fara AF, Subias M, Pickering MC, Drouet C, Meri S, Arstila TP, Pekkarinen PT, Ma M, Cope A, Reinheckel T, Rodriguez de Cordoba S, Afzali B, Atkinson JP, Kemper C.
Immunity. 2013 Dec 12;39(6):1143-57. doi: 10.1016/j.immuni.2013.10.018. Epub 2013 Dec 5.
1 Protocol published
Enzymatic Reactions and Detection of C3 Cleavage Fragments
Authors:  Claudia Kemper and Martin Kolev, date: 08/20/2014, view: 6531, Q&A: 0
The complement component C3 is the major effector molecule of the complement system. C3 circulates in the blood and interstitial fluids as pro-enzyme and is activated by enzymatic cleavage into a C3a portion, a classic anaphylatoxin that functions ...
11 Protocols reviewed
Click Chemistry (CuAAC) and Detection of Tagged de novo Synthesized Proteins in Drosophila
Copper-catalyzed azide-alkyne-cycloaddition (CuAAC), also known as ‘click chemistry’ serves as a technique for bio-orthogonal, that is, bio-compatible labeling of macromolecules including proteins or lipids. Click chemistry has been widely used to ...
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Generation of Busulfan Chimeric Mice for the Analysis of T Cell Population Dynamics
Authors:  Thea Hogan, Andrew Yates and Benedict Seddon, date: 12/20/2017, view: 3277, Q&A: 0
This protocol was developed to generate chimeric mice in which T lymphocytes could be stratified by age on the basis of congenic marker expression. The conditioning drug busulfan is used to ablate host haematopoietic stem cells while leaving the ...
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