Thomas Bartosh Texas A&M University
2 protocols

Joni H. Ylostalo
  • Institute for Regenerative Medicine, Texas A&M University Health Science Center, USA
Research focus
  • Stem cell
  • 2 Author merit


Ph.D. in Biomedical Sciences, Tulane University School of Medicine, New Orleans, LA, 2008

Current position

Instructor, Institute for Regenerative Medicine, Texas A&M Health Science Center COM, Temple, TX
Adjunct Instructor, Department of Biology, University of Mary Hardin-Baylor, Belton, TX


  1. Bartosh, T. J. and Ylostalo, J. H. (2014). Preparation of anti-inflammatory mesenchymal stem/precursor cells (MSCs) through sphere formation using hanging-drop culture technique. Curr Protoc Stem Cell Biol 28: Unit 2B 6.
  2. Bartosh, T. J.*, Ylostalo, J. H.*, Bazhanov, N., Kuhlman, J. and Prockop, D. J. (2013). Dynamic compaction of human mesenchymal stem/precursor cells into spheres self-activates caspase-dependent IL1 signaling to enhance secretion of modulators of inflammation and immunity (PGE2, TSG6, and STC1). Stem Cells 31(11): 2443-2456.
  3. Ylöstalo, J. H. and Bartosh, T. J. (2013). Mesenchymal Stem Cells Characteristics, Niches, and Applications for Cell Therapy. Volume (2): 429-470.
  4. Ylostalo, J. H.*, Bartosh, T. J.*, Coble, K. and Prockop, D. J. (2012).Human mesenchymal stem/stromal cells cultured as spheroids are self-activated to produce prostaglandin E2 that directs stimulated macrophages into an anti-inflammatory phenotype. Stem Cells 30(10): 2283-2296.
  5.  Horie, M., Choi, H., Lee, R. H., Reger, R. L., Ylostalo, J., Muneta, T., Sekiya, I. and Prockop, D. J. (2012). Intra-articular injection of human mesenchymal stem cells (MSCs) promote rat meniscal regeneration by being activated to express Indian hedgehog that enhances expression of type II collagen.  Osteoarthritis Cartilage 20(10): 1197-1207.
  6.  Oh, J. Y., Choi, H., Lee, R. H., Roddy, G. W., Ylöstalo, J. H., Wawrousek, E. and Prockop, D. J. (2012). Identification of the HSPB4/TLR2/NFκB axis in macrophage as a therapeutic target for sterile inflammation of the cornea. EMBO molecular medicine 4(5): 435-448.
  7.  Roddy, G. W., Rosa, R. H., Jr., Oh, J. Y., Ylostalo, J. H., Bartosh, T. J., Jr., Choi, H., Lee, R. H., Yasumura, D., Ahern, K., Nielsen, G., Matthes, M. T., LaVail, M. M. and Prockop, D. J. (2012). Stanniocalcin-1 rescued photoreceptor degeneration in two rat models of inherited retinal degeneration. Mol Ther 20(4): 788-797.
  8. Foraker, J. E., Oh, J. Y., Ylostalo, J. H., Lee, R. H., Watanabe, J. and Prockop, D. J. (2011). Crosstalk between human mesenchymal stem/progenitor cells (MSCs) and rat hippocampal slices in LPSstimulated cocultures: the MSCs are activated to secrete prostaglandin E2. Journal of neurochemistry 119(5): 1052-1063.
  9.  Roddy, G. W., Oh, J. Y., Lee, R. H., Bartosh, T. J., Ylostalo, J., Coble, K., Rosa, R. H. and Prockop, D. J. (2011).  Action at a Distance: Systemically Administered Adult Stem/Progenitor Cells (MSCs) Reduce Inflammatory Damage to the Cornea Without Engraftment and Primarily by Secretion of TNFα Stimulated Gene/Protein 6. Stem Cells 29(10): 1572-1579.
  10.  Danchuk, S., Ylostalo, J. H., Hossain, F., Sorge, R., Ramsey, A., Bonvillain, R. W., Lasky, J. A., Bunnell, B. A., Welsh, D. A., Prockop, D. J. and Sullivan, D. E. (2011).  Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor-alpha-induced protein 6. Stem Cell Res Ther 2(3): 27.
  11. Oh, J. Y., Roddy, G. W., Choi, H., Lee, R. H., Ylostalo, J. H., Rosa, R. H., Jr. and Prockop, D. J. (2010). Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury. Proc Natl Acad Sci U S A 107(39): 16875-16880.
  12. Fresquet, M., Jowitt, T. A., Stephen, L. A., Ylöstalo, J. and Briggs, M. D. (2010).  Structural and functional investigations of Matrilin-1 A-domains reveal insights into their role in cartilage ECM assembly. Journal of Biological Chemistry 285(44): 34048-34061.
  13.  Bartosh, T. J.*, Ylostalo, J. H.*, Mohammadipoor, A., Bazhanov, N., Coble, K., Claypool, K., Lee, R. H., Choi, H. and Prockop, D. J. (2010).  Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties. Proc Natl Acad Sci U S A 107(31): 13724-13729.
  14. Larson, B. L., Ylostalo, J., Lee, R. H., Gregory, C. and Prockop, D. J. (2010). Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells. Tissue engineering Part A 16(11): 3385-3394.
  15.  Robinson, A. P., Foraker, J. E., Ylostalo, J. and Prockop, D. J. (2011). Human stem/progenitor cells from bone marrow enhance glial differentiation of rat neural stem cells: a role for transforming growth factor beta and Notch signaling. Stem Cells Dev 20(2): 289-300.
  16.  Krause, U., Harris, S., Green, A., Ylostalo, J., Zeitouni, S., Lee, N. and Gregory, C. A. (2010). Pharmaceutical modulation of canonical Wnt signaling in multipotent stromal cells for improved osteoinductive therapy. Proc Natl Acad Sci U S A 107(9): 4147-4152.
  17.  Bakondi, B., Shimada, I. S., Perry, A., Munoz, J. R., Ylostalo, J., Howard, A. B., Gregory, C. A. and Spees, J. L. (2009). CD133 identifies a human bone marrow stem/progenitor cell sub-population with a repertoire of secreted factors that protect against stroke. Mol Ther 17(11): 1938-1947.
  18.  Lee, R. H., Pulin, A. A., Seo, M. J., Kota, D. J., Ylostalo, J., Larson, B. L., Semprun-Prieto, L., Delafontaine, P. and Prockop, D. J. (2009). Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell stem cell 5(1): 54-63.
    *Equal contribution
2 Protocols published
Mesenchymal Stem Cell (MSC) Aggregate Formation in vivo
Authors:  Thomas J. Bartosh and Joni H. Ylostalo, date: 07/20/2014, view: 10526, Q&A: 0
Human mesenchymal stem/progenitor cells (MSCs) isolated from various adult tissues show remarkable therapeutic potential and are being employed in clinical trials for the treatment of numerous diseases (Prockop et al., 2010). While routes ...
Macrophage Inflammatory Assay
Authors:  Thomas J. Bartosh and Joni H. Ylostalo, date: 07/20/2014, view: 27358, Q&A: 0
Macrophages represent a widely distributed and functionally diverse population of innate myeloid cells involved in inflammatory response to pathogens, tissue homeostasis and tissue repair (Murray and Wynn, 2011). Macrophages can be broadly grouped ...
We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.