Jennifer Philips Department of Medicine, Division of Infectious Diseases, New York University School of Medicine, USA
1 protocol
Achille Broggi Harvard Medical School
15 protocols

Alexandros Kokotos Weill Cornell Medicine
13 protocols

Amit Dey International Centre for Genetic Engineering and Biotechnology
14 protocols

Amriti Lulla UT MD Anderson Cancer Center
6 protocols

Editor
Alka Mehra
  • Research scientist, Institute of Genomics and Integrative Biology
Research focus
  • Microbiology
  • host-pathogen interactions, macrophages, innate immunity, microbiology, cellular trafficking pathways, signaling, microRNAs.
  • 2 Author merit

Education

Ph.D., Jawaharlal Nehru University

Publications

1. Portal-Celhay C, Tufariello JM, Srivastava S, Zahra A, Klevorn T, Grace PS, Mehra A, Park HS, Ernst JD, Jacobs Jr. WR, and Philips JA. (2016) Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4+ T cell activation. Nature Microbiology Dec5 (2) 16232.

2. Mehra A. (2015). Microbial CRISPR-Cas System: From Bacterial Immunity to Next-Generation Antimicrobials. Microbial Factories (Springer India 2015, ISBN No.: 978-81-322-2594-2) Volume 2, Chapter 14. 217-234. DOI: 10.1007/978-81-322-2595-9_14.

3. Mehra A. (2014). Phagolysosomal Trafficking Assay. Bio-protocol 4 (13) e1163; DOI: https://dx.doi.org/10.21769/BioProtoc.1163.

4. Mehra A* and Philips JA*. (2014). Analysis of Mycobacterial Protein Secretion. Bio-protocol 4 (12) e1159; *Co-corresponding author. DOI: https://dx.doi.org/10.21769/BioProtoc.1159.

5. Siegrist MS, Steigedal M, Ahmad R, Mehra A, Dragset MS, Schuster BM, Philips JA, Carr SA, Rubin EJ. (2014). Mycobacterial Esx-3 requires multiple components for iron acquisition. mBio. 5 (3) e01073-14.

6. Mehra A*, Zahra A*, Thompson V, Sirisaengtaksin N, Wells A, Porto M, Köster S, Penberthy K, Kubota Y, Dricot A, Rogan D, Vidal M, Bean AJ, Hill D, Philips JA. (2013). Mycobacterium tuberculosis type VII secreted effector, EsxH targets host ESCRT to inhibit intracellular trafficking. PLOS Pathogens. 9(10) e100373. * Equal contribution.

7. Singh Y, Kaul V, Mehra A, Chatterjee S, Tousif S, Dwivedi VP, Suar M, Kaer LV, Bishai WR and Das G. (2013). Mycobacterium tuberculosis controls miR99b expression in infected murine dendritic cells to modulate host immunity. Journal of Biological Chemistry. Feb 15; 288(7): 5056-61.

8. Juranek J, Kothary P, Mehra A, Hays A, Brannagan III TH, Schmidt AM. (2013). Increased expression of the Receptor for Advanced End-Glycation Products in the neuropathic peripheral nerve of human patients. Brain and Behaviour. 3(6) 701-709.

9. Mehra A, Bhattacharya S and Bhattacharya A. (2007). Identification of a novel lysine rich protein from Entamoeba histolytica. American J Biochemistry and Biotechnology. 3(4): 193-198.

10. Mehra A, Fredrick J, Petri WA Jr, Bhattacharya S and Bhattacharya A. (2006). Expression and function of a family of transmembrane kinases from the protozoan parasite Entamoeba histolytica. Infect and Immun. Sep; 74(9): 5341-51.

11. Arya R, Mehra A, Bhattacharya S, Vishwakarma RA and Bhattacharya A. (2003). Biosynthesis of Entamoeba histolytica Proteophosphoglycan in vitro. Mol. Biochem. Parasitol. Jan, 126 (1): 1-8.
2 Protocols published
Phagolysosomal Trafficking Assay
Author:  Alka Mehra, date: 07/05/2014, view: 12019, Q&A: 0
Phagolysosomal trafficking is an important innate defense pathway that clears microbes by delivering them to lysosomes, the degradative compartment of the cell. Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, subverts ...
Analysis of Mycobacterial Protein Secretion
Authors:  Alka Mehra and Jennifer A. Philips, date: 06/20/2014, view: 10446, Q&A: 0
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis. Analysis of proteins secreted by Mtb has been of interest to the field of tuberculosis research since certain secreted proteins interact with the host to promote ...
8 Protocols reviewed
Adoptive Transfer of Monocytes Sorted from Bone Marrow
Authors:  Damya Laoui, Eva Van Overmeire, Chloé Abels, Jiri Keirsse and Jo A Van Ginderachter, date: 01/05/2019, view: 3826, Q&A: 0
Inflammatory Ly6Chi monocytes can give rise to distinct mononuclear myeloid cells in the tumor microenvironment, such as monocytic myeloid-derived suppressor cells (Mo-MDSC), immature macrophages, M2-like tumor-associated macrophages ...
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In vivo Imaging of Tumor and Immune Cell Interactions in the Lung
Authors:  Richard N. Hanna, Grzegorz Chodaczek and Catherine C. Hedrick, date: 10/20/2016, view: 6337, Q&A: 0
Immunotherapy has demonstrated great therapeutic potential by activating the immune system to fight cancer. However, little is known about the specific dynamics of interactions that occur between tumor and immune cells. In this protocol we describe ...
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28 Protocols edited
SMART (Single Molecule Analysis of Resection Tracks) Technique for Assessing DNA end-Resection in Response to DNA Damage
DNA double strand breaks (DSBs) are among the most toxic lesions affecting genome integrity. DSBs are mainly repaired through non-homologous end joining (NHEJ) and homologous recombination (HR). A crucial step of the HR process is the generation, ...
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Isolation of Lipid Rafts from Cultured Mammalian Cells and Their Lipidomics Analysis
Authors:  Nigora Mukhamedova, Kevin Huynh, Hann Low, Peter J. Meikle and Dmitri Sviridov, date: 07/05/2020, view: 861, Q&A: 0
Lipid rafts are distinct liquid-ordered domains of plasma membranes of most eukaryotic cells providing platform for signaling pathways. Lipid composition of rafts is critical for their structural integrity and for regulation of signaling pathways ...
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