Education
Ph.D. in Biochemistry, Hebrew University of Jerusalem, Jerusalem, Israel, 1995
Current position
Associate Professor, Department of Biological Regulation, Weizmann Institute of Science (2007-present)
Publications (since 2005)
Original contributions
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Weaver, D., Eisner, V., Liu, X., Varnai, P., Hunyady, L., Gross, A. and Hajnoczky, G. (2014). Distribution and Apoptotic Function of Outer Membrane Proteins Depend on Mitochondrial Fusion. Mol Cell. (Epub ahead of print)
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Shamas-Din, A., Bindner, S., Zhu, W., Zaltsman, Y., Campbell, C., Gross, A., Leber, B., Andrews, D. W. and Fradin, C. (2013). tBid undergoes multiple conformational changes at the membrane required for Bax activation. J Biol Chem 288(30): 22111-22127.
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Cabon, L., Galan-Malo, P., Bouharrour, A., Delavallee, L., Brunelle-Navas, M. N., Lorenzo, H. K., Gross, A. and Susin, S. A. (2012). BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation. Cell Death Differ 19(2): 245-256.
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Katz, C., Zaltsman-Amir, Y., Mostizky, Y., Kollet, N., Gross, A. and Friedler, A. (2012). Molecular basis of the interaction between proapoptotic truncated BID (tBID) protein and mitochondrial carrier homologue 2 (MTCH2) protein: key players in mitochondrial death pathway. J Biol Chem 287(18): 15016-15023.
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Maryanovich, M., Oberkovitz, G., Niv, H., Vorobiyov, L., Zaltsman, Y., Brenner, O., Lapidot, T., Jung, S. and Gross, A. (2012). The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells. Nat Cell Biol 14(5): 535-541.
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Yivgi-Ohana, N., Eifer, M., Addadi, Y., Neeman, M. and Gross, A. (2011). Utilizing mitochondrial events as biomarkers for imaging apoptosis. Cell Death Dis 2: e166.
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Zaltsman, Y., Shachnai, L., Yivgi-Ohana, N., Schwarz, M., Maryanovich, M., Houtkooper, R. H., Vaz, F. M., De Leonardis, F., Fiermonte, G., Palmieri, F., Gillissen, B., Daniel, P. T., Jimenez, E., Walsh, S., Koehler, C. M., Roy, S. S., Walter, L., Hajnoczky, G. and Gross, A. (2010). MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria. Nat Cell Biol 12(6): 553-562.
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Ziporen, L., Donin, N., Shmushkovich, T., Gross, A. and Fishelson, Z. (2009). Programmed necrotic cell death induced by complement involves a Bid-dependent pathway. J Immunol 182(1): 515-521.
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Schungel, S., Buitrago-Molina, L. E., Nalapareddy, P., Lebofsky, M., Manns, M. P., Jaeschke, H., Gross, A. and Vogel, A. (2009). The strength of the Fas ligand signal determines whether hepatocytes act as type 1 or type 2 cells in murine livers. Hepatology 50(5): 1558-1566.
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Yacobi, K., Tsafriri, A. and Gross, A. (2007). Luteinizing hormone-induced caspase activation in rat preovulatory follicles is coupled to mitochondrial steroidogenesis. Endocrinology 148(4): 1717-1726.
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Konig, H. G., Rehm, M., Gudorf, D., Krajewski, S., Gross, A., Ward, M. W. and Prehn, J. H. (2007). Full length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons. BMC Cell Biol 8: 7.
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Oberkovitz, G., Regev, L. and Gross, A. (2007). Nucleocytoplasmic shuttling of BID is involved in regulating its activities in the DNA-damage response. Cell Death Differ 14(9): 1628-1634.
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Zinkel, S. S., Hurov, K. E., Ong, C., Abtahi, F. M., Gross, A. and Korsmeyer, S. J. (2005). A role for proapoptotic BID in the DNA-damage response. Cell 122(4): 579-591.
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Grinberg, M., Schwarz, M., Zaltsman, Y., Eini, T., Niv, H., Pietrokovski, S. and Gross, A. (2005). Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Mol Cell Biol 25(11): 4579-4590.
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Kamer, I., Sarig, R., Zaltsman, Y., Niv, H., Oberkovitz, G., Regev, L., Haimovich, G., Lerenthal, Y., Marcellus, R. C. and Gross, A. (2005). Proapoptotic BID is an ATM effector in the DNA-damage response. Cell 122(4): 593-603.
Invited reviews/commenteries
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Zinkel, S. S., Yin, X. M. and Gross, A. (2013). Rejuvenating Bi(d)ology. Oncogene 32(27): 3213-3219.
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Maryanovich, M. and Gross, A. (2013). A ROS rheostat for cell fate regulation. Trends Cell Biol 23(3): 129-134.
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Robinson, A. J., Kunji, E. R. and Gross, A. (2012). Mitochondrial carrier homolog 2 (MTCH2): the recruitment and evolution of a mitochondrial carrier protein to a critical player in apoptosis. Exp Cell Res 318(11): 1316-1323.
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Gross, A. (2011). A yeast BH3-only protein for the rescue. Cell Death Differ 18(10): 1543-1544.
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Gross, A. (2010). M(a)TCH-ing up mitochondrial apoptosis. Cell Cycle 9(15): 2925-2926.
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Gross, A. (2010). Aven-uing between nuclear export and cell cycle arrest. Cell Cycle 9(20): 4043-4044.
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Gross, A. (2008). A new Aven-ue to DNA-damage checkpoints. Trends Biochem Sci 33(11): 514-516.
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Schwarz, M., Andrade-Navarro, M. A. and Gross, A. (2007). Mitochondrial carriers and pores: key regulators of the mitochondrial apoptotic program? Apoptosis 12(5): 869-876.
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Zinkel, S. S., Hurov, K. E. and Gross, A. (2007). Bid plays a role in the DNA damage response. Cell 130(1): 9-10; author reply 10-11.
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Gross, A. (2006). BID as a double agent in cell life and death. Cell Cycle 5(6): 582-584.
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Zinkel, S., Gross, A. and Yang, E. (2006). BCL2 family in DNA damage and cell cycle control. Cell Death Differ 13(8): 1351-1359.
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Gross, A. (2005). Mitochondrial carrier homolog 2: a clue to cracking the BCL-2 family riddle? J Bioenerg Biomembr 37(3): 113-119.