Fayezeh Aarabi Max-Planck-Institut für Molekulare Pflanzenphysiologie, Max-Planck-Institut für Molekulare Pflanzenphysiologie, Germany
2 protocols

Gad Galili Department of Plant Sciences, Weizmann Institute of Science, Israel
1 protocol

Ruthie Angelovici Department of Plant Sciences, Weizmann Institute of Science, Israel
1 protocol

Vered Tzin Department of Plant Sciences, Weizmann Institute of Science, Israel
1 protocol

Sonia Osorio
  • Instituto de Hortofruticultura Subtropical y Mediterránea “La Mayora” – University of Malaga- Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC)
Research focus
  • Plant science
  • 1 Author merit


Ph.D. in Plant Science, Department of Molecular Biology and Biochemistry, University of Malaga, Spain, 2006

Current position

Independent Researcher (Ramon and Cajal program. Ministry of Economy and Competitiveness, Spain), Dept. Molecular Biology and Biochemistry, University of Malaga, Spain


  1. Bermudez, L., de Godoy, F., Baldet, P., Demarco, D., Osorio, S., Quadrana, L., Almeida, J., Asis, R., Gibon, Y., Fernie, A. R., Rossi, M. and Carrari, F. (2014). Silencing of the tomato sugar partitioning affecting protein (SPA) modifies sink strength through a shift in leaf sugar metabolism. Plant J 77(5): 676-687.
  2. Lauxmann, M. A., Borsani, J., Osorio, S., Lombardo, V. A., Budde, C. O., Bustamante, C. A., Monti, L. L., Andreo, C. S., Fernie, A. R. and Drincovich, M. F. (2014). Deciphering the metabolic pathways influencing heat and cold responses during post‐harvest physiology of peach fruit. Plant, Cell & Environment 37(3): 601-616.
  3. Bastías, A., Yañez, M., Osorio, S., Arbona, V., Gómez-Cadenas, A., Fernie, A. R. and Casaretto, J. A. (2014). The transcription factor AREB1 regulates primary metabolic pathways in tomato fruits. Journal of experimental botany: eru114. (Accepted)
  4. Klie, S., Osorio, S.*, Tohge, T., Drincovich, M. F., Fait, A., Giovannoni, J. J., Fernie, A. R. and Nikoloski, Z. (2014). Conserved changes in the dynamics of metabolic processes during fruit development and ripening across species. Plant Physiol 164(1): 55-68. *Corresponding author
  5. Osorio, S.*, Vallarino, J. G., Szecowka, M., Ufaz, S., Tzin, V., Angelovici, R., Galili, G. and Fernie, A. R. (2013). Alteration of the interconversion of pyruvate and malate in the plastid or cytosol of ripening tomato fruit invokes diverse consequences on sugar but similar effects on cellular organic acid, metabolism, and transitory starch accumulation. Plant Physiol 161(2): 628-643. *Corresponding author
  6. Cascales-Minana, B., Munoz-Bertomeu, J., Flores-Tornero, M., Anoman, A. D., Pertusa, J., Alaiz, M., Osorio, S., Fernie, A. R., Segura, J. and Ros, R. (2013). The phosphorylated pathway of serine biosynthesis is essential both for male gametophyte and embryo development and for root growth in Arabidopsis. Plant Cell 25(6): 2084-2101.
  7. Osorio, S.*, Nunes-Nesi, A., Stratmann, M. and Fernie, A. R. (2013). Pyrophosphate levels strongly influence ascorbate and starch content in tomato fruit. Front Plant Sci 4: 308. *Corresponding author
  8. Merchante, C., Vallarino, J. G., Osorio, S., Araguez, I., Villarreal, N., Ariza, M. T., Martinez, G. A., Medina-Escobar, N., Civello, M. P., Fernie, A. R., Botella, M. A. and Valpuesta, V. (2013). Ethylene is involved in strawberry fruit ripening in an organ-specific manner. J Exp Bot 64(14): 4421-4439.
  9. Araguez, I., Osorio, S., Hoffmann, T., Rambla, J. L., Medina-Escobar, N., Granell, A., Botella, M. A., Schwab, W. and Valpuesta, V. (2013). Eugenol production in achenes and receptacles of strawberry fruits is catalyzed by synthases exhibiting distinct kinetics. Plant Physiol 163(2): 946-958.
  10. Nardozza, S., Boldingh, H. L., Osorio, S., Hohne, M., Wohlers, M., Gleave, A. P., MacRae, E. A., Richardson, A. C., Atkinson, R. G., Sulpice, R., Fernie, A. R. and Clearwater, M. J. (2013). Metabolic analysis of kiwifruit (Actinidia deliciosa) berries from extreme genotypes reveals hallmarks for fruit starch metabolism. J Exp Bot 64(16): 5049-5063.
  11. Antonio, C., Mustafa, N. R., Osorio, S., Tohge, T., Giavalisco, P., Willmitzer, L., Rischer, H., Oksman-Caldentey, K. M., Verpoorte, R. and Fernie, A. R. (2013). Analysis of the interface between primary and secondary metabolism in catharanthus roseus cell cultures using (13)C-stable isotope feeding and coupled mass spectrometry. Mol Plant 6(2): 581-584.
  12. Morgan, M. J., Osorio, S., Gehl, B., Baxter, C. J., Kruger, N. J., Ratcliffe, R. G., Fernie, A. R. and Sweetlove, L. J. (2013). Metabolic engineering of tomato fruit organic acid content guided by biochemical analysis of an introgression line. Plant Physiol 161(1): 397-407.
  13. Consortium, T. G. (2012). The tomato genome sequence provides insights into fleshy fruit evolution. Nature 485(7400): 635-641.
  14. Szecowka, M., Osorio, S., Obata, T., Araujo, W. L., Rohrmann, J., Nunes-Nesi, A. and Fernie, A. R. (2012). Decreasing the mitochondrial synthesis of malate in potato tubers does not affect plastidial starch synthesis, suggesting that the physiological regulation of ADPglucose pyrophosphorylase is context dependent. Plant Physiol 160(4): 2227-2238.
  15. Osorio, S., Alba, R., Nikoloski, Z., Kochevenko, A., Fernie, A. R. and Giovannoni, J. J. (2012). Integrative comparative analyses of transcript and metabolite profiles from pepper and tomato ripening and development stages uncovers species-specific patterns of network regulatory behavior. Plant Physiol 159(4): 1713-1729.
  16. Alejandro, S., Lee, Y., Tohge, T., Sudre, D., Osorio, S., Park, J., Bovet, L., Geldner, N., Fernie, A. R. and Martinoia, E. (2012). AtABCG29 is a monolignol transporter involved in lignin biosynthesis. Curr Biol 22(13): 1207-1212.
  17. Hampp, C.*, Richter, A.*, Osorio, S.*, Zellnig, G., Sinha, A. K., Jammer, A., Fernie, A. R., Grimm, B. and Roitsch, T. (2012). Establishment of a photoautotrophic cell suspension culture of Arabidopsis thaliana for photosynthetic, metabolic, and signaling studies. Mol Plant 5(2): 524-527.
    *These authors contribute equality to this work
  18. Araujo, W. L., Tohge, T., Osorio, S., Lohse, M., Balbo, I., Krahnert, I., Sienkiewicz-Porzucek, A., Usadel, B., Nunes-Nesi, A. and Fernie, A. R. (2012). Antisense inhibition of the 2-oxoglutarate dehydrogenase complex in tomato demonstrates its importance for plant respiration and during leaf senescence and fruit maturation. Plant Cell 24(6): 2328-2351.
  19. Chen, L. Q., Qu, X. Q., Hou, B. H., Sosso, D., Osorio, S., Fernie, A. R. and Frommer, W. B. (2012). Sucrose efflux mediated by SWEET proteins as a key step for phloem transport. Science 335(6065): 207-211.
  20. Lytovchenko, A., Eickmeier, I., Pons, C., Osorio, S., Szecowka, M., Lehmberg, K., Arrivault, S., Tohge, T., Pineda, B., Anton, M. T., Hedtke, B., Lu, Y., Fisahn, J., Bock, R., Stitt, M., Grimm, B., Granell, A. and Fernie, A. R. (2011). Tomato fruit photosynthesis is seemingly unimportant in primary metabolism and ripening but plays a considerable role in seed development. Plant Physiol 157(4): 1650-1663.
  21. Lombardo, V. A., Osorio, S., Borsani, J., Lauxmann, M. A., Bustamante, C. A., Budde, C. O., Andreo, C. S., Lara, M. V., Fernie, A. R. and Drincovich, M. F. (2011). Metabolic profiling during peach fruit development and ripening reveals the metabolic networks that underpin each developmental stage. Plant Physiol 157(4): 1696-1710.
  22. Djamei, A., Schipper, K., Rabe, F., Ghosh, A., Vincon, V., Kahnt, J., Osorio, S., Tohge, T., Fernie, A. R., Feussner, I., Feussner, K., Meinicke, P., Stierhof, Y. D., Schwarz, H., Macek, B., Mann, M. and Kahmann, R. (2011). Metabolic priming by a secreted fungal effector. Nature 478(7369): 395-398.
  23. Steinbrenner, A. D., Gomez, S., Osorio, S., Fernie, A. R. and Orians, C. M. (2011). Herbivore-induced changes in tomato (Solanum lycopersicum) primary metabolism: a whole plant perspective. J Chem Ecol 37(12): 1294-1303.
  24. Dal Cin, V., Tieman, D. M., Tohge, T., McQuinn, R., de Vos, R. C., Osorio, S., Schmelz, E. A., Taylor, M. G., Smits-Kroon, M. T., Schuurink, R. C., Haring, M. A., Giovannoni, J., Fernie, A. R. and Klee, H. J. (2011). Identification of genes in the phenylalanine metabolic pathway by ectopic expression of a MYB transcription factor in tomato fruit. Plant Cell 23(7): 2738-2753.
  25. O Osorio, S., Alba, R., Damasceno, C. M., Lopez-Casado, G., Lohse, M., Zanor, M. I., Tohge, T., Usadel, B., Rose, J. K., Fei, Z., Giovannoni, J. J. and Fernie, A. R. (2011). Systems biology of tomato fruit development: combined transcript, protein, and metabolite analysis of tomato transcription factor (nor, rin) and ethylene receptor (Nr) mutants reveals novel regulatory interactions. Plant Physiol 157(1): 405-425.
  26. Rohrmann, J., Tohge, T., Alba, R., Osorio, S., Caldana, C., McQuinn, R., Arvidsson, S., van der Merwe, M. J., Riano-Pachon, D. M., Mueller-Roeber, B., Fei, Z., Nesi, A. N., Giovannoni, J. J. and Fernie, A. R. (2011). Combined transcription factor profiling, microarray analysis and metabolite profiling reveals the transcriptional control of metabolic shifts occurring during tomato fruit development. Plant J 68(6): 999-1013.
  27. Araujo, W. L., Nunes-Nesi, A., Osorio, S., Usadel, B., Fuentes, D., Nagy, R., Balbo, I., Lehmann, M., Studart-Witkowski, C., Tohge, T., Martinoia, E., Jordana, X., Damatta, F. M. and Fernie, A. R. (2011). Antisense inhibition of the iron-sulphur subunit of succinate dehydrogenase enhances photosynthesis and growth in tomato via an organic acid-mediated effect on stomatal aperture. Plant Cell 23(2): 600-627.
  28. Osorio, S., Bombarely, A., Giavalisco, P., Usadel, B., Stephens, C., Araguez, I., Medina-Escobar, N., Botella, M. A., Fernie, A. R. and Valpuesta, V. (2011). Demethylation of oligogalacturonides by FaPE1 in the fruits of the wild strawberry Fragaria vesca triggers metabolic and transcriptional changes associated with defence and development of the fruit. J Exp Bot 62(8): 2855-2873.
  29. Centeno, D. C.*, Osorio, S.*, Nunes-Nesi, A., Bertolo, A. L., Carneiro, R. T., Araujo, W. L., Steinhauser, M. C., Michalska, J., Rohrmann, J., Geigenberger, P., Oliver, S. N., Stitt, M., Carrari, F., Rose, J. K. and Fernie, A. R. (2011). Malate plays a crucial role in starch metabolism, ripening, and soluble solid content of tomato fruit and affects postharvest softening. Plant Cell 23(1): 162-184.
    *These authors contribute equality to this work
  30. Csukasi, F., Osorio, S., Gutierrez, J. R., Kitamura, J., Giavalisco, P., Nakajima, M., Fernie, A. R., Rathjen, J. P., Botella, M. A., Valpuesta, V. and Medina-Escobar, N. (2011). Gibberellin biosynthesis and signalling during development of the strawberry receptacle. New Phytol 191(2): 376-390.
  31. Gur, A., Semel, Y., Osorio, S., Friedmann, M., Seekh, S., Ghareeb, B., Mohammad, A., Pleban, T., Gera, G., Fernie, A. R. and Zamir, D. (2011). Yield quantitative trait loci from wild tomato are predominately expressed by the shoot. Theor Appl Genet 122(2): 405-420.
  32. Leuendorf, J. E., Osorio, S., Szewczyk, A., Fernie, A. R. and Hellmann, H. (2010). Complex assembly and metabolic profiling of Arabidopsis thaliana plants overexpressing vitamin B(6) biosynthesis proteins. Mol Plant 3(5): 890-903.
  33. Sulpice, R., Sienkiewicz-Porzucek, A., Osorio, S., Krahnert, I., Stitt, M., Fernie, A. R. and Nunes-Nesi, A. (2010). Mild reductions in cytosolic NADP-dependent isocitrate dehydrogenase activity result in lower amino acid contents and pigmentation without impacting growth. Amino Acids 39(4): 1055-1066.
  34. Lohse, M., Nunes-Nesi, A., Kruger, P., Nagel, A., Hannemann, J., Giorgi, F. M., Childs, L., Osorio, S., Walther, D., Selbig, J., Sreenivasulu, N., Stitt, M., Fernie, A. R. and Usadel, B. (2010). Robin: an intuitive wizard application for R-based expression microarray quality assessment and analysis. Plant Physiol 153(2): 642-651.
  35. Gur, A., Osorio, S., Fridman, E., Fernie, A. R. and Zamir, D. (2010). hi2-1, a QTL which improves harvest index, earliness and alters metabolite accumulation of processing tomatoes. Theor Appl Genet 121(8): 1587-1599.
  36. Nashilevitz, S., Melamed-Bessudo, C., Izkovich, Y., Rogachev, I., Osorio, S., Itkin, M., Adato, A., Pankratov, I., Hirschberg, J., Fernie, A. R., Wolf, S., Usadel, B., Levy, A. A., Rumeau, D. and Aharoni, A. (2010). An orange ripening mutant links plastid NAD(P)H dehydrogenase complex activity to central and specialized metabolism during tomato fruit maturation. Plant Cell 22(6): 1977-1997.
  37. van der Merwe, M. J.*, Osorio, S.*, Araujo, W. L., Balbo, I., Nunes-Nesi, A., Maximova, E., Carrari, F., Bunik, V. I., Persson, S. and Fernie, A. R. (2010). Tricarboxylic acid cycle activity regulates tomato root growth via effects on secondary cell wall production. Plant Physiol 153(2): 611-621.
    *These authors contribute equality to this work
  38. Sienkiewicz-Porzucek, A., Sulpice, R., Osorio, S., Krahnert, I., Leisse, A., Urbanczyk-Wochniak, E., Hodges, M., Fernie, A. R. and Nunes-Nesi, A. (2010). Mild reductions in mitochondrial NAD-dependent isocitrate dehydrogenase activity result in altered nitrate assimilation and pigmentation but do not impact growth. Mol Plant 3(1): 156-173.
  39. Mueller, L. A., Lankhorst, R. K., Tanksley, S. D., Giovannoni, J. J., White, R., Vrebalov, J., Fei, Z., van Eck, J., Buels, R. and Mills, A. A. (2009). A snapshot of the emerging tomato genome sequence. The Plant Genome 2(1): 78-92.
  40. sorio, S.*, Nunes-Nesi, A., Carrari, F., Lohse, M., Usadel, B., Kuhn, C., Bleiss, W., Giavalisco, P., Willmitzer, L., Sulpice, R., Zhou, Y. H. and Fernie, A. R. (2009). RNA interference of LIN5 in tomato confirms its role in controlling Brix content, uncovers the influence of sugars on the levels of fruit hormones, and demonstrates the importance of sucrose cleavage for normal fruit development and fertility. Plant Physiol 150(3): 1204-1218.
    *These authors contribute equality to this work
  41. Wirth, J., Poletti, S., Aeschlimann, B., Yakandawala, N., Drosse, B., Osorio, S., Tohge, T., Fernie, A. R., Gunther, D., Gruissem, W. and Sautter, C. (2009). Rice endosperm iron biofortification by targeted and synergistic action of nicotianamine synthase and ferritin. Plant Biotechnol J 7(7): 631-644.
  42. van der Merwe, M. J., Osorio, S., Moritz, T., Nunes-Nesi, A. and Fernie, A. R. (2009). Decreased mitochondrial activities of malate dehydrogenase and fumarase in tomato lead to altered root growth and architecture via diverse mechanisms. Plant Physiol 149(2): 653-669.
  43. Osorio, S., Castillejo, C., Quesada, M. A., Medina-Escobar, N., Brownsey, G. J., Suau, R., Heredia, A., Botella, M. A. and Valpuesta, V. (2008). Partial demethylation of oligogalacturonides by pectin methyl esterase 1 is required for eliciting defence responses in wild strawberry (Fragaria vesca). Plant J 54(1): 43-55.
  44. Fernández, S., Osorio, S. and Heredia, A. (1999). Monitoring and visualising plant cuticles by confocal laser scanning microscopy. Plant Physiology and Biochemistry 37(10): 789-794.

Other publications - indexed (reviews, books, methods)

  1. Osorio, S.* and Yong-Ling, R., Fernie, A. R., (2014). An update on source-to-sink carbon partitioning in tomato. Frontier in Function Plant Ecology (Submitted)
    Sonia Osorio as corresponding author
  2. Osorio, S.*, Scossa, F. and Fernie, A. R. (2013). Molecular regulation of fruit ripening. Front Plant Sci 4: 198.
    Sonia Osorio as corresponding author
  3. Osorio, S. and Fernie, A. R. (2013). Chapter 11, Essay 11.2. Metabolic Profiling of Plant Cells. In: Taiz, L. and Zeiger, E. (eds). Plant Physiology.
  4. Vallarino, J. G. and Osorio, S.* (2012). Signaling role of oligogalacturonides derived during cell wall degradation. Plant Signal Behav 7(11): 1-3.
    Sonia Osorio as corresponding author
  5. Ruan, Y. L., Patrick, J. W., Bouzayen, M., Osorio, S. and Fernie, A. R. (2012). Molecular regulation of seed and fruit set. Trends Plant Sci 17(11): 656-665.
  6. Osorio, S. and Fernie, A. R. (2012). Fruit ripening: Primary metabolism. In: Nath, P., Bouzayen, M.,  Mattoo, A., Pech, J. C. (eds). Fruit ripening: from physiology, signaling and genomics to post-genomics. CABI publishers. (In press)
  7. Osorio, S., Do, P. T. and Fernie, A. R. (2012). Profiling primary metabolites of tomato fruit with gas chromatography/mass spectrometry. Methods Mol Biol 860: 101-109.
  8. Fitzpatrick, T. B., Basset, G. J., Borel, P., Carrari, F., DellaPenna, D., Fraser, P. D., Hellmann, H., Osorio, S., Rothan, C., Valpuesta, V., Caris-Veyrat, C. and Fernie, A. R. (2012). Vitamin deficiencies in humans: can plant science help? Plant Cell 24(2): 395-414.
  9. Osorio, S. and Fernie, A. R. (2012). Plant Systems Biology. In: Meyers, R. A. (ed). Encyclopedia of Molecular Cell Biology and Molecular Medicine. Wiley-Blackwell, 685-697.
  10. Osorio, S. and Fernie, A. R. (2011). Primary metabolism in ripening fruits. In: J. Giovannoni, M. Poole, G.B. Seymour and G.A. Tucker (eds). Fruit ripening: Molecular Biology and Biochemistry. Wiley-Blackwell. (In press)
  11. Osorio, S., Muñoz, C. and Valpuesta, V. (2010). Physiology and biochemistry of plant flavor. In: F. Cheng (ed). Handbook of fruit flavors. Wiley-Interscience, 1-120.
  12. Do, P. D. and Osorio, S., Fernie, A. R. (2010). Chapter 11, Essay 11.2. Metabolic Profiling of Plant Cells. In: Taiz, L. and Zeiger, E. (eds). Plant Physiology.
  13. Osorio, S., Tohge, T. and Fernie, A. (2009). Application of metabolomic profiling for identifying valuable traits in tomato. CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources 4(024): 1-9.
1 Protocol published
Extraction and Measurement the Activities of Cytosolic Phosphoenolpyruvate Carboxykinase (PEPCK) and Plastidic NADP-dependent Malic Enzyme (ME) on Tomato (Solanum lycopersicum)
A recent study demonstrated that cytosolic phosphoenolpyruvate carboxykinase (PEPCK) and NADP-malic enzyme (NADP-ME) have an important role in malate metabolism during fruit ripening (Osorio et al., 2013). PEPCK catalyze the ATP-dependent ...
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