Menachem Shoham
  • Department of Biochemistry, Case Western Reserve University, USA
  • 1 Author merit


Ph.D. in Chemistry (Protein Crystallography), Weizmann Institute of Science, Rehovot, Israel, 1978

Current position

Associate Professor in Biochemistry and General Medical Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio (1990-present)


Selected from a total of 57 peer-reviewed publications

  1. Khodaverdian, V., Pesho, M., Truitt, B., Bollinger, L., Patel, P., Nithianantham, S., Yu, G., Delaney, E., Jankowsky, E. and Shoham, M. (2013). Discovery of antivirulence agents against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 57(8): 3645-3652.
  2. Shoham, M. (2011). Antivirulence agents against MRSA. Future Med Chem 3(7): 775-777.
  3. Temoin, S., Wu, K. L., Wu, V., Shoham, M. and Han, Y. W. (2012). Signal peptide of FadA adhesin from Fusobacterium nucleatum plays a novel structural role by modulating the filament's length and width. FEBS Lett 586(1): 1-6.
  4. Siddiqui, A. A., Xainli, J., Schloegel, J., Carias, L., Ntumngia, F., Shoham, M., Casey, J. L., Foley, M., Adams, J. H. and King, C. L. (2012). Fine specificity of Plasmodium vivax Duffy binding protein binding engagement of the Duffy antigen on human erythrocytes. Infect Immun 80(8): 2920-2928.
  5. Fardini, Y., Wang, X., Temoin, S., Nithianantham, S., Lee, D., Shoham, M. and Han, Y. W. (2011). Fusobacterium nucleatum adhesin FadA binds vascular endothelial cadherin and alters endothelial integrity. Mol Microbiol 82(6): 1468-1480.
  6. T Saks, J., Truitt, B. and Shoham, M. (2011). Specificity of Three Vasopressin Receptor Antagonists. Letters in Drug Design & Discovery 8(6): 529-535.
  7. Stone, M. J., Chuang, S., Hou, X., Shoham, M. and Zhu, J. Z. (2009). Tyrosine sulfation: an increasingly recognised post-translational modification of secreted proteins. N Biotechnol 25(5): 299-317.
  8. Nithianantham, S., Xu, M., Yamada, M., Ikegami, A., Shoham, M. and Han, Y. W. (2009). Crystal structure of FadA adhesin from Fusobacterium nucleatum reveals a novel oligomerization motif, the leucine chain. J Biol Chem 284(6): 3865-3872.
  9. Kiran, M. D., Adikesavan, N. V., Cirioni, O., Giacometti, A., Silvestri, C., Scalise, G., Ghiselli, R., Saba, V., Orlando, F., Shoham, M. and Balaban, N. (2008). Discovery of a quorum-sensing inhibitor of drug-resistant staphylococcal infections by structure-based virtual screening. Mol Pharmacol 73(5): 1578-1586.
  10. Macion-Dazard, R., Callahan, N., Xu, Z., Wu, N., Thibonnier, M. and Shoham, M. (2006). Mapping the binding site of six nonpeptide antagonists to the human V2-renal vasopressin receptor. J Pharmacol Exp Ther 316(2): 564-571.
  11. Wu, N., Macion-Dazard, R., Nithianantham, S., Xu, Z., Hanson, S. M., Vishnivetskiy, S. A., Gurevich, V. V., Thibonnier, M. and Shoham, M. (2006). Soluble mimics of the cytoplasmic face of the human V1-vascular vasopressin receptor bind arrestin2 and calmodulin. Mol Pharmacol 70(1): 249-258.
  12. Wu, N., Hanson, S. M., Francis, D. J., Vishnivetskiy, S. A., Thibonnier, M., Klug, C. S., Shoham, M. and Gurevich, V. V. (2006). Arrestin binding to calmodulin: a direct interaction between two ubiquitous signaling proteins. J Mol Biol 364(5): 955-963.
  13. Thibonnier, M., Coles, P., Thibonnier, A. and Shoham, M. (2002). Molecular pharmacology and modeling of vasopressin receptors. Prog Brain Res 139: 179-196.
  14. Zarivach, R., Ben-Zeev, E., Wu, N., Auerbach, T., Bashan, A., Jakes, K., Dickman, K., Kosmidis, A., Schluenzen, F., Yonath, A., Eisenstein, M. and Shoham, M. (2002). On the interaction of colicin E3 with the ribosome. Biochimie 84(5-6): 447-454.
  15. Soelaiman, S., Jakes, K., Wu, N., Li, C. and Shoham, M. (2001). Crystal structure of colicin E3: implications for cell entry and ribosome inactivation. Mol Cell 8(5): 1053-1062.
  16. Thibonnier, M., Coles, P., Thibonnier, A. and Shoham, M. (2001). The basic and clinical pharmacology of nonpeptide vasopressin receptor antagonists. Annu Rev Pharmacol Toxicol 41: 175-202.
  17. Thibonnier, M., Coles, P., Conarty, D. M., Plesnicher, C. L. and Shoham, M. (2000). A molecular model of agonist and nonpeptide antagonist binding to the human V(1) vascular vasopressin receptor. J Pharmacol Exp Ther 294(1): 195-203.
  18. Li, C., Zhao, D., Djebli, A. and Shoham, M. (1999). Crystal structure of colicin E3 immunity protein: an inhibitor of a ribosome-inactivating RNase. Structure 7(11): 1365-1372.
  19. Roth, B. L., Shoham, M., Choudhary, M. S. and Khan, N. (1997). Identification of conserved aromatic residues essential for agonist binding and second messenger production at 5-hydroxytryptamine2A receptors. Mol Pharmacol 52(2): 259-266.
1 Protocol published
ELISA for Alpha-hemolysin (Hla) in Methicilin-resistant Staphylococcus aureus (MRSA)
Authors:  Varandt Y. Khodaverdian and Menachem Shoham, date: 05/05/2014, view: 5970, Q&A: 0
Anti-virulence agents against MRSA inhibit the production of disease-causing virulence factors, such as alpha-hemolysin, but are neither bacteriostatic nor bactericidal. Here we discuss a rapid method to screen for MRSA anti-virulence agents by ...
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