Erik Sahai Tumour Cell Biology Lab, CRUK London Research Institute, UK
1 protocol

Steven Hooper Tumour Cell Biology lab, CRUK London Research Institute, UK
1 protocol

Fernando Calvo
  • Institute of Cancer Research
Research focus
  • Cancer biology
  • 1 Author merit


Ph.D. in Biochemistry, Department of Molecular Biology, Universidad de Cantabria, Spain, 2008

Current position

Career Development Faculty-Team Leader, Tumour Microenvironment Team, Division of Cancer Biology, Institute of Cancer Research, London, UK


  1. Ferrari, N. and Calvo, F. (2014). Tumor microenvironment: unleashing metalloproteinases to induce a CAF phenotype. Curr Biol 24(20): R1009-1011.
  2. Suresh Babu, S., Valdez, Y., Xu, A., O'Byrne, A. M., Calvo, F., Lei, V. and Conway, E. M. (2014). TGFbeta-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells. BMC Cancer 14(1): 113.
  3. Calvo, F., Ege, N., Grande-Garcia, A., Hooper, S., Jenkins, R. P., Chaudhry, S. I., Harrington, K., Williamson, P., Moeendarbary, E., Charras, G. and Sahai, E. (2013). Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts. Nat Cell Biol 15(6): 637-646.
  4. Crespo, P., Calvo, F. and Sanz-Moreno, V. (2011). Ras and Rho GTPases on the move: The RasGRF connection. Bioarchitecture 1(4): 200-204.
  5. Arozarena, I., Calvo, F. and Crespo, P. (2011). Ras, an actor on many stages: posttranslational modifications, localization, and site-specified events. Genes Cancer 2(3): 182-194.
  6. Calvo, F., Sanz-Moreno, V., Agudo-Ibanez, L., Wallberg, F., Sahai, E., Marshall, C. J. and Crespo, P. (2011). RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation. Nat Cell Biol 13(7): 819-826.
  7. Calvo, F. and Sahai, E. (2011). Cell communication networks in cancer invasion. Curr Opin Cell Biol 23(5): 621-629.
  8. Rodriguez, J., Calvo, F., Gonzalez, J. M., Casar, B., Andres, V. and Crespo, P. (2010). ERK1/2 MAP kinases promote cell cycle entry by rapid, kinase-independent disruption of retinoblastoma-lamin A complexes. J Cell Biol 191(5): 967-979.
  9. Calvo, F., Agudo-Ibanez, L. and Crespo, P. (2010). The Ras-ERK pathway: understanding site-specific signaling provides hope of new anti-tumor therapies. Bioessays 32(5): 412-421.
  10. Calvo, F. and Crespo, P. (2009). Structural and spatial determinants regulating TC21 activation by RasGRF family nucleotide exchange factors. Mol Biol Cell 20(20): 4289-4302.
  11. Vaque, J. P., Fernandez-Garcia, B., Garcia-Sanz, P., Ferrandiz, N., Bretones, G., Calvo, F., Crespo, P., Marin, M. C. and Leon, J. (2008). c-Myc inhibits Ras-mediated differentiation of pheochromocytoma cells by blocking c-Jun up-regulation. Mol Cancer Res 6(2): 325-339.
  12. Agudo-Ibanez, L., Nunez, F., Calvo, F., Berenjeno, I. M., Bustelo, X. R. and Crespo, P. (2007). Transcriptomal profiling of site-specific Ras signals. Cell Signal 19(11): 2264-2276.
  13. Martinez, S. E., Lazaro-Dieguez, F., Selva, J., Calvo, F., Piqueras, J. R., Crespo, P., Claro, E. and Egea, G. (2007). Lysophosphatidic acid rescues RhoA activation and phosphoinositides levels in astrocytes exposed to ethanol. J Neurochem 102(4): 1044-1052.
  14. Matallanas, D., Sanz-Moreno, V., Arozarena, I., Calvo, F., Agudo-Ibanez, L., Santos, E., Berciano, M. T. and Crespo, P. (2006). Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation. Mol Cell Biol 26(1): 100-116.
  15. Arozarena, I., Matallanas, D., Berciano, M. T., Sanz-Moreno, V., Calvo, F., Munoz, M. T., Egea, G., Lafarga, M. and Crespo, P. (2004). Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors. Mol Cell Biol 24(4): 1516-1530.

Book Chapters, protocols and miscellanea

  1. Calvo, F. and Crespo, P. (2008). RASGRF1 (Ras protein-specific guanine nucleotide-releasing factor 1). Atlas Genet Cytogenet Oncol Haematol
1 Protocol published
Isolation and Immortalization of Fibroblasts from Different Tumoral Stages
Authors:  Fernando Calvo, Steven Hooper and Erik Sahai, date: 04/05/2014, view: 9783, Q&A: 0
Tumour microenvironment and cancer-associated fibroblasts in particular exhibit tumour promoting abilities that are not present in their normal counterparts (Calvo et al., 2013; Hanahan and Coussens, 2012). Therefore, functional and ...