William Agace Immunology Section, Lund University, Sweden
1 protocol

Petra Nilsson Immunology Section, Lund University, Sweden
1 protocol

Emma Persson Immunology Section, Lund University, Sweden
1 protocol

Heli Uronen-Hansson
  • Immunology Section, Lund University, Sweden
Research focus
  • Immunology
  • 1 Author merit


Ph.D. in Immunobiology, Institute of Child Health, University College London, United Kingdom

Current position

Research scientist, Section of Immunology, Lund University, Sweden


  1. Thiesen, S., Janciauskiene, S., Uronen-Hansson, H., Agace, W., Hogerkorp, C. M., Spee, P., Hakansson, K. and Grip, O. (2014). CD14hiHLA-DRdim macrophages, with a resemblance to classical blood monocytes, dominate inflamed mucosa in Crohn's disease. J Leukoc Biol 95(3): 531-541.
  2. Persson, E. K., Uronen-Hansson, H., Semmrich, M., Rivollier, A., Hagerbrand, K., Marsal, J., Gudjonsson, S., Hakansson, U., Reizis, B., Kotarsky, K. and Agace, W. W. (2013). IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation. Immunity 38(5): 958-969.
  3. Bain, C. C., Scott, C. L., Uronen-Hansson, H., Gudjonsson, S., Jansson, O., Grip, O., Guilliams, M., Malissen, B., Agace, W. W. and Mowat, A. M. (2013). Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors. Mucosal Immunol 6(3): 498-510.
  4. Poulin, L. F., Reyal, Y., Uronen-Hansson, H., Schraml, B. U., Sancho, D., Murphy, K. M., Hakansson, U. K., Moita, L. F., Agace, W. W., Bonnet, D. and Reis e Sousa, C. (2012). DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues. Blood 119(25): 6052-6062.
  5. Semmrich, M., Plantinga, M., Svensson-Frej, M., Uronen-Hansson, H., Gustafsson, T., Mowat, A. M., Yrlid, U., Lambrecht, B. N. and Agace, W. W. (2012). Directed antigen targeting in vivo identifies a role for CD103+ dendritic cells in both tolerogenic and immunogenic T-cell responses. Mucosal Immunol 5(2): 150-160.
  6. Jaensson, E., Uronen-Hansson, H., Pabst, O., Eksteen, B., Tian, J., Coombes, J. L., Berg, P. L., Davidsson, T., Powrie, F., Johansson-Lindbom, B. and Agace, W. W. (2008). Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J Exp Med 205(9): 2139-2149.
  7. Steeghs, L., Keestra, A. M., van Mourik, A., Uronen-Hansson, H., van der Ley, P., Callard, R., Klein, N. and van Putten, J. P. (2008). Differential activation of human and mouse Toll-like receptor 4 by the adjuvant candidate LpxL1 of Neisseria meningitidis. Infect Immun 76(8): 3801-3807.
  8. Jones, H. E., Strid, J., Osman, M., Uronen-Hansson, H., Dixon, G., Klein, N., Wong, S. Y. and Callard, R. E. (2008). The role of beta2 integrins and lipopolysaccharide-binding protein in the phagocytosis of dead Neisseria meningitidis. Cell Microbiol 10(8): 1634-1645.
  9. Svensson, M., Marsal, J., Uronen-Hansson, H., Cheng, M., Jenkinson, W., Cilio, C., Jacobsen, S. E., Sitnicka, E., Anderson, G. and Agace, W. W. (2008). Involvement of CCR9 at multiple stages of adult T lymphopoiesis. J Leukoc Biol 83(1): 156-164.
  10. Jones, H. E., Uronen-Hansson, H., Callard, R. E., Klein, N. and Dixon, G. L. (2007). The differential response of human dendritic cells to live and killed Neisseria meningitidis. Cell Microbiol 9(12): 2856-2869.
  11. Steeghs, L., van Vliet, S. J., Uronen-Hansson, H., van Mourik, A., Engering, A., Sanchez-Hernandez, M., Klein, N., Callard, R., van Putten, J. P., van der Ley, P., van Kooyk, Y. and van de Winkel, J. G. (2006). Neisseria meningitidis expressing lgtB lipopolysaccharide targets DC-SIGN and modulates dendritic cell function. Cell Microbiol 8(2): 316-325.
  12. Uronen-Hansson, H., Steeghs, L., Allen, J., Dixon, G. L., Osman, M., van der Ley, P., Wong, S. Y., Callard, R. and Klein, N. (2004). Human dendritic cell activation by Neisseria meningitidis: phagocytosis depends on expression of lipooligosaccharide (LOS) by the bacteria and is required for optimal cytokine production. Cell Microbiol 6(7): 625-637.
  13. Uronen-Hansson, H., Allen, J., Osman, M., Squires, G., Klein, N. and Callard, R. E. (2004). Toll-like receptor 2 (TLR2) and TLR4 are present inside human dendritic cells, associated with microtubules and the Golgi apparatus but are not detectable on the cell surface: integrity of microtubules is required for interleukin-12 production in response to internalized bacteria. Immunology 111(2): 173-178.
  14. Uronen-Hansson, H., Allen, M. L., Lichtarowicz-Krynska, E., Aynsley-Green, A., Cole, T. J., Hoiden-Guthenberg, I., Fryklund, L. and Klein, N. (2003). Growth hormone enhances proinflammatory cytokine production by monocytes in whole blood. Growth Horm IGF Res 13(5): 282-286.
  15. Cruccetti, A., Pierro, A., Uronen, H. and Klein, N. (2003). Surgical infants on total parenteral nutrition have impaired cytokine responses to microbial challenge. Journal of pediatric surgery 38(1): 138-142.
  16. Uronen, H., Williams, A. J., Dixon, G., Andersen, S. R., Van Der Ley, P., Van Deuren, M., Callard, R. E. and Klein, N. (2000). Gram-negative bacteria induce proinflammatory cytokine production by monocytes in the absence of lipopolysaccharide (LPS). Clin Exp Immunol 122(3): 312-315.
  17. Uronen, H. and Callard, R. E. (2000). Absence of CD40-CD40 ligand interactions in X-linked hyper-IgM syndrome does not affect differentiation of T helper cell subsets. Clin Exp Immunol 121(2): 346-352.
1 Protocol published
Isolation of Cells from Human Intestinal Tissue
Authors:  Heli Uronen-Hansson, Emma Persson, Petra Nilsson and William Agace, date: 04/05/2014, view: 13549, Q&A: 0
The intestinal lamina propria contains a dense network of T cells, dendritic cells (DCs) and macrophages, which play an important role in local innate and adaptive immune responses. We have recently identified distinct subsets of DCs (Persson et al. ...
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