Francisco Ciruela Departament de Patologia i Terapèutica Experimental, Universitat de Barcelona, España
4 protocols

Amadeu Llebaria 2 protocols

Marc López-Cano 1 protocol

Kenneth A. Jacobson National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA
2 protocols

Víctor Fernández-Dueñas
  • Departament de Patologia i Terapèutica Experimental, Universitat de Barcelona-IDIBELL, Spain
Research focus
  • Neuroscience
  • 2 Author merit


Ph. D. in Neurosciences, Universitat Autònoma de Barcelona, Barcelona, Spain, 2006

Current position

Assistant Professor in Pharmacology, School of Medicine, Universitat de Barcelona, Barcelona, Spain


  1. Gomez-Soler, M., Fernandez-Duenas, V., Portillo-Salido, E., Perez, P., Zamanillo, D., Vela, J. M., Burgueno, J. and Ciruela, F. (2014). Predicting the antinociceptive efficacy of sigma(1) receptor ligands by a novel receptor fluorescence resonance energy transfer (FRET) based biosensor. J Med Chem 57(1): 238-242.
  2. Vallano, A., Fernandez-Duenas, V., Garcia-Negredo, G., Quijada, M. A., Simon, C. P., Cuffi, M. L., Carbonell, L., Sanchez, S., Arnau, J. M. and Ciruela, F. (2013). Targeting striatal metabotropic glutamate receptor type 5 in Parkinson's disease: bridging molecular studies and clinical trials. CNS Neurol Disord Drug Targets 12(8): 1128-1142.
  3. Fernandez-Duenas, V., Gomez-Soler, M., Morato, X., Nunez, F., Das, A., Kumar, T. S., Jauma, S., Jacobson, K. A. and Ciruela, F. (2013). Dopamine D(2) receptor-mediated modulation of adenosine A(2A) receptor agonist binding within the A(2A)R/D(2)R oligomer framework. Neurochem Int 63(1): 42-46.
  4. Gandia, J., Fernandez-Duenas, V., Morato, X., Caltabiano, G., Gonzalez-Muniz, R., Pardo, L., Stagljar, I. and Ciruela, F. (2013). The Parkinson's disease-associated GPR37 receptor-mediated cytotoxicity is controlled by its intracellular cysteine-rich domain. J Neurochem 125(3): 362-372.
  5. Fernandez-Duenas, V., Gomez-Soler, M., Jacobson, K. A., Kumar, S. T., Fuxe, K., Borroto-Escuela, D. O. and Ciruela, F. (2012). Molecular determinants of A2AR-D2R allosterism: role of the intracellular loop 3 of the D2R. J Neurochem 123(3): 373-384.
  6. Canela, L., Selga, E., Garcia-Martinez, J. M., Amaral, O. B., Fernandez-Duenas, V., Alberch, J., Canela, E. I., Franco, R., Noe, V., Lluis, C., Ciudad, C. J. and Ciruela, F. (2012). Transcriptional profiling of striatal neurons in response to single or concurrent activation of dopamine D2, adenosine A(2A) and metabotropic glutamate type 5 receptors: focus on beta-synuclein expression. Gene 508(2): 199-205.
  7. Fernandez-Duenas, V., Llorente, J., Gandia, J., Borroto-Escuela, D. O., Agnati, L. F., Tasca, C. I., Fuxe, K. and Ciruela, F. (2012). Fluorescence resonance energy transfer-based technologies in the study of protein-protein interactions at the cell surface. Methods 57(4): 467-472.
  8. Ciruela, F., Fernandez-Duenas, V., Llorente, J., Borroto-Escuela, D., Cuffi, M. L., Carbonell, L., Sanchez, S., Agnati, L. F., Fuxe, K. and Tasca, C. I. (2012). G protein-coupled receptor oligomerization and brain integration: focus on adenosinergic transmission. Brain Res 1476: 86-95.
  9. Fernandez-Duenas, V., Poveda, R., Sanchez, S. and Ciruela, F. (2012). Synergistic interaction between fentanyl and a tramadol: paracetamol combination on the inhibition of nociception in mice. J Pharmacol Sci 118(2): 299-302.
  10. Vallano, A., Fernandez-Duenas, V., Pedros, C., Arnau, J. M. and Ciruela, F. (2011). An update on adenosine A2A receptors as drug target in Parkinson's disease. CNS Neurol Disord Drug Targets 10(6): 659-669.
  11. Lopez-Hernandez, T., Sirisi, S., Capdevila-Nortes, X., Montolio, M., Fernandez-Duenas, V., Scheper, G. C., van der Knaap, M. S., Casquero, P., Ciruela, F., Ferrer, I., Nunes, V. and Estevez, R. (2011). Molecular mechanisms of MLC1 and GLIALCAM mutations in megalencephalic leukoencephalopathy with subcortical cysts. Hum Mol Genet 20(16): 3266-3277.
  12. Caballero, M., Nunez, F., Ahern, S., Cuffi, M. L., Carbonell, L., Sanchez, S., Fernandez-Duenas, V. and Ciruela, F. (2011). Caffeine improves attention deficit in neonatal 6-OHDA lesioned rats, an animal model of attention deficit hyperactivity disorder (ADHD). Neurosci Lett 494(1): 44-48.
  13. Ciruela, F., Gomez-Soler, M., Guidolin, D., Borroto-Escuela, D. O., Agnati, L. F., Fuxe, K. and Fernandez-Duenas, V. (2011). Adenosine receptor containing oligomers: their role in the control of dopamine and glutamate neurotransmission in the brain. Biochim Biophys Acta 1808(5): 1245-1255.
  14. Fernandez-Duenas, V., Poveda, R., Fernandez, A., Sanchez, S., Planas, E. and Ciruela, F. (2011). Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain. Pharmacol Biochem Behav 98(3): 331-336.
  15. Ciruela, F., Fernandez-Duenas, V., Sahlholm, K., Fernandez-Alacid, L., Nicolau, J. C., Watanabe, M. and Lujan, R. (2010). Evidence for oligomerization between GABAB receptors and GIRK channels containing the GIRK1 and GIRK3 subunits. Eur J Neurosci 32(8): 1265-1277.
  16. Ciruela, F., Vallano, A., Arnau, J. M., Sanchez, S., Borroto-Escuela, D. O., Agnati, L. F., Fuxe, K. and Fernandez-Duenas, V. (2010). G protein-coupled receptor oligomerization for what? J Recept Signal Transduct Res 30(5): 322-330.
  17. Ciruela, F., Vilardaga, J. P. and Fernandez-Duenas, V. (2010). Lighting up multiprotein complexes: lessons from GPCR oligomerization. Trends Biotechnol 28(8): 407-415.
  18. Fernandez-Duenas, V., Ciruela, F., Gandia, J., Sanchez, S., Planas, E. and Poveda, R. (2010). Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice. Eur J Pharmacol 638(1-3): 72-77.
  19. Fuxe, K., Marcellino, D., Borroto-Escuela, D. O., Guescini, M., Fernandez-Duenas, V., Tanganelli, S., Rivera, A., Ciruela, F. and Agnati, L. F. (2010). Adenosine-dopamine interactions in the pathophysiology and treatment of CNS disorders. CNS Neurosci Ther 16(3): e18-42.
  20. Ciruela, F., Albergaria, C., Soriano, A., Cuffi, L., Carbonell, L., Sanchez, S., Gandia, J. and Fernandez-Duenas, V. (2010). Adenosine receptors interacting proteins (ARIPs): Behind the biology of adenosine signaling. Biochim Biophys Acta 1798(1): 9-20.
  21. Canela, L., Fernandez-Duenas, V., Albergaria, C., Watanabe, M., Lluis, C., Mallol, J., Canela, E. I., Franco, R., Lujan, R. and Ciruela, F. (2009). The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function. J Neurochem 111(2): 555-567.
  22. Fernandez-Duenas, V., Sanchez, S., Planas, E. and Poveda, R. (2008). Adjuvant effect of caffeine on acetylsalicylic acid anti-nociception: prostaglandin E2 synthesis determination in carrageenan-induced peripheral inflammation in rat. Eur J Pain 12(2): 157-163.
  23. Fernandez-Duenas, V., Pol, O., Garcia-Nogales, P., Hernandez, L., Planas, E. and Puig, M. M. (2007). Tolerance to the antinociceptive and antiexudative effects of morphine in a murine model of peripheral inflammation. J Pharmacol Exp Ther 322(1): 360-368.
  24. Poveda, R., Fernandez-Duenas, V., Fernandez, A., Sanchez, S., Puig, M. M. and Planas, E. (2006). Synergistic interaction between fentanyl and the histamine H3 receptor agonist R-(alpha)-methylhistamine, on the inhibition of nociception and plasma extravasation in mice. Eur J Pharmacol 541(1-2): 53-56.
2 Protocols published
Authors:  Marc López-Cano, Víctor Fernández-Dueñas, Amadeu Llebaria and Francisco Ciruela, date: 12/05/2017, view: 8103, Q&A: 0
Pain research is mostly based on experimental assays that use animal models, which may allow deciphering the physiopathology of this condition and to propel drug discovery. The formalin nociception test is considered one of the most predictive ...
Authors:  Víctor Fernández-Dueñas, Kenneth A. Jacobson and Francisco Ciruela, date: 03/20/2014, view: 9206, Q&A: 0
We designed a fluorescence resonance energy transfer (FRET)-based approach to study the ligand binding constants of the adenosine A2A receptor (A2AR). Our assay is based in the interaction of a fluorescent A2AR ...
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